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The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test

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Abstract

Rationale

There is a significant delay in the clinical response of antidepressant drugs, and antidepressant treatments produce side effects.

Objective

We examined the relationship between 17β-estradiol and topiramate in ovariectomized Wistar rats submitted to the forced swimming test (FST).

Methods

Topiramate was administered alone or combined with 17β-estradiol to ovariectomized rats submitted to the FST.

Results

Topiramate (20 mg/kg, P < 0.05; 30 mg/kg, P < 0.05) reduced immobility by increasing swimming; these effects were antagonized by finasteride (50 mg/kg). In interaction experiments, topiramate (10 mg/kg) plus 17β-estradiol (5 micrograms per rat; P < 0.05) reduced immobility by increasing swimming behavior. Besides, 17β-estradiol (2.5 micrograms per rat) shortened the onset of the antidepressant-like effects of topiramate (P < 0.05). In the open field test, topiramate alone or combined with 17β-estradiol (P < 0.05) reduced locomotion.

Conclusions

Topiramate alone or combined with 17β-estradiol produced antidepressant-like actions; and 17β-estradiol shortened the onset of the antidepressant-like effects of topiramate.

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Acknowledgments

This study was supported by grant no. 52932 from the Consejo Nacional de Ciencia y Tecnología (CONACyT), México. We thank Warren Haid for revising the manuscript. We acknowledge the substantive and thoughtful suggestions offered by anonymous reviewers.

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Authors and Affiliations

  1. Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México

    Miguel Molina-Hernández & N. Patricia Téllez-Alcántara

  2. División Ciencias de la Salud, Universidad Autónoma Metropolitana, lztapalapa, Cd. de México, México

    Jorge I. Olivera-López & M. Teresa Jaramillo

  3. Dr. Castelazo S/N, Xalapa, Veracruz, 91000, México

    Miguel Molina-Hernández

Authors
  1. Miguel Molina-Hernández
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  2. N. Patricia Téllez-Alcántara
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  3. Jorge I. Olivera-López
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  4. M. Teresa Jaramillo
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Correspondence to Miguel Molina-Hernández.

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Molina-Hernández, M., Téllez-Alcántara, N.P., Olivera-López, J.I. et al. The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test. Psychopharmacology 231, 3343–3350 (2014). https://doi.org/10.1007/s00213-013-3251-1

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  • DOI: https://doi.org/10.1007/s00213-013-3251-1

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