Abstract
The hypothesis was tested that an initial lithium-tricyclic antidepressant (TCA) combination has a better antidepressant effect than standard TCA treatment in non-refractory depression at the beginning of an episode. Twenty bipolar melancholic type depressed inpatients under lithium-TCA treatment were compared with 20 patients with the same diagnosis and TCA-placebo treatment for 5 weeks under double-blind conditions. All patients were male. Initial lithium-TCA treatment reduced depressive symptoms significantly more than antidepressant treatment with TCA and placebo after 5 weeks, but not in weeks 1 or 2. It can be concluded that lithium augmentation of TCA treatment should be started even at the beginning of antidepressant TCA treatment to provide a better treatment response in those patients who will profit from long-term lithium prophylaxis, e.g. bipolar patients with melancholic type depression.
References
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn. Washington DC
Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56–62
Price LH (1989) Lighium augmentation in tricyclic-resistant depression. In: Extein IL, ed. American Psychiatric Press, Washington DC, pp 49–79
Price LH, Heninger GR (1994) Lithium in the treatment of mood disorders. N Engl J Med 331: 591–598
Schöpf J (1989) Treatment of depressions resistant to tricyclic antidepressants, related drugs or MAO inhibitors by lithium addition: review of the literature. Pharmacopsychiatry 22: 174–182
Souza FGM, Goodwin GM (1991) Lithium treatment and prophylaxis in unipolar depression: a meta-analysis. Br J Psychiatry 158: 666–657
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Ebert, D., Jaspert, A., Murata, H. et al. Initial lithium augmentation improves the antidepressant effects of standard TCA treatment in non-resistant depressed patients. Psychopharmacology 118, 223–225 (1995). https://doi.org/10.1007/BF02245845
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DOI: https://doi.org/10.1007/BF02245845