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Psychopharmacology

, Volume 227, Issue 2, pp 355–361 | Cite as

Effects of repeated exposure to MDMA on 5HT1a autoreceptor function: behavioral and neurochemical responses to 8-OHDPAT

  • Susan SchenkEmail author
  • Blaine Abraham
  • Dane Aronsen
  • Joyce Colussi-Mas
  • Jennifer Do
Original Investigation

Abstract

A consistent effect of repeated exposure to 3,4 methylenedioxymethamphetamine (MDMA) is a decrease in the tissue levels of serotonin (5-HT). A variety of behavioural and neurochemical tests were conducted to determine whether the tissue deficits were accompanied by an increased sensitivity of the 5-HT1a autoreceptor. Tests were conducted 2 weeks following MDMA exposure (four injections of 10.0 mg/kg, IP, administered at 2-h intervals in a single day). The response to the 5-HT1a agonist, 8-OHDPAT (0.003–0.5 mg/kg, SC), was assessed using lower lip retraction (LLR), hypoactivity, and 5-hydroxytryptophan (5-HTP) accumulation following decarboxylase inhibition. The 8-OHDPAT produced a dose-dependent increase in LLR and hypoactivity, but these effects were comparable for MDMA and saline pretreated groups. MDMA decreased tissue levels of 5-HT and the accumulation of 5-HTP, but these effects were not reflected in the changes in autoreceptor sensitivity. The data suggest that the decrease in tissue levels of 5-HT produced by MDMA is accompanied by a decrease in tryptophan hydroxylase activity but cannot be explained by supersensitivity of the 5-HT1a autoreceptor.

Keywords

MDMA Serotonin Autoreceptor Tryptophan hydroxylase 8-OHDPAT 

Notes

Acknowledgments

The authors gratefully acknowledge the technical assistance of Richard Moore. These studies were funded by the Royal Society of New Zealand Marsden Fund.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Susan Schenk
    • 1
    Email author
  • Blaine Abraham
    • 1
  • Dane Aronsen
    • 1
  • Joyce Colussi-Mas
    • 1
  • Jennifer Do
    • 1
  1. 1.School of PsychologyVictoria University of WellingtonWellingtonNew Zealand

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