Abstract
Rationale
Decision making is thought to play a key role in psychostimulant relapse, but very few studies have addressed the issue of how to counteract decision-making deficits in addicted individuals. According to the somatic marker framework, pervasive decision-making problems in addicted individuals may relate to abnormalities in the processing of emotional signals that work to anticipate the prospective outcomes of potential decisions.
Objective
The present study was conducted to test whether the induction of different emotional states (positive, negative, or drug-related) could either normalize or further impair decision-making performance in male cocaine polysubstance-using individuals (CPSI), as indexed by the Iowa gambling task (IGT).
Methods
Forty-two CPSI and 65 healthy control individuals (all males) were randomly allocated in four affective conditions using a parallel-group design. Participants in the different conditions performed the IGT during exposure to neutral, positive, negative, or drug-related sets of affective images.
Results
The results showed that the CPSI exposed to the negative affective context showed a preference for the risk-averse safe choices of the IGT and had a net performance indistinguishable from that of controls. On the other hand, CPSI exposed to positive, drug-related, and neutral contexts showed the typical pattern of disadvantageous performance in the IGT and performed significantly poorer than controls. The impact of the negative mood induction could not be explained in terms of baseline differences in decision-making skills, personality traits related to sensitivity to reward/punishment, or trait positive/negative affect.
Conclusions
We conclude that negative mood induction can normalize decision-making performance in male CPSI, which may have important implications for the treatment of cocaine use-related disorders.
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Acknowledgment
This work was funded by the Spanish Ministry of Education under the FPU national plan (grant reference AP 2005-1411) and grant SEJ 2006-8278 by the Junta de Andalucía through the grant P07.HUM 03089 and by the Plan Nacional sobre Drogas (2009), COPERNICO grant.
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Fernández-Serrano, M.J., Moreno-López, L., Pérez-García, M. et al. Negative mood induction normalizes decision making in male cocaine dependent individuals. Psychopharmacology 217, 331–339 (2011). https://doi.org/10.1007/s00213-011-2288-2
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DOI: https://doi.org/10.1007/s00213-011-2288-2