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Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes

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Abstract

Rationale

Methamphetamine attenuates disruptions that occur after changes in work shifts. The reinforcing effects of the drug during shift work have yet to be characterized.

Objectives

This study examined methamphetamine-related mood, performance, and reinforcing effects during simulated shift work.

Materials and methods

Ten volunteers (four women and six men) completed this 19-day study. Participants were given an opportunity to self-administer oral methamphetamine (10 mg) or receive a $1 voucher before and after an 8-h work period for four consecutive days under two shift conditions: (1) “day shift” in which they went to bed at 2400 hours and woke up at 0800 hours and (2) “night shift” when they went to bed at 1600 hours and woke up at 2400 hours. Thus, participants completed task batteries either from 0815 to 1715 hours or from 0015 to 0915 hours. Shift conditions alternated three times during the study and were separated by an “off” day.

Results

Night-shift work disrupted psychomotor task performance and some ratings of mood, especially on the first night. Consistent with this, participants chose to take methamphetamine significantly more often on the first night-shift night compared with the first day-shift day. Regardless of shift condition, however, participants selected markedly more methamphetamine doses before the work period than after it (73% versus 34%).

Conclusions

These data show that methamphetamine self-administration occurred more often before work rather than after work, suggesting that the use of stimulants by shift workers may be one strategy employed to meet behavioral demands especially under conditions engendering poor performance, fatigue, and/or sleep disruptions.

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References

  • Ajilore O, Stickgold R, Rittenhouse CD, Hobson JA (1995) Nightcap: laboratory and home-based evaluation of a portable sleep monitor. Psychophysiology 32:92–98

    Article  CAS  PubMed  Google Scholar 

  • Baranski JV, Pigeau RA (1997) Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo. J Sleep Res 6:84–91

    CAS  PubMed  Google Scholar 

  • Cantero JL, Atienza M, Stickgold R, Hobson JA (2002) Nightcap: a reliable system for determining sleep onset latency. Sleep 25:238–245

    PubMed  Google Scholar 

  • Cho AK, Melega WP, Kuczenski R, Segal DS (2001) Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse. Synapse 39:161–166

    Article  CAS  PubMed  Google Scholar 

  • Comer SD, Haney M, Foltin RW, Fischman MW (1996) Amphetamine self-administration by humans: modulation by contingencies associated with task performance. Psychopharmacology (Berl) 127:39–46

    Article  CAS  Google Scholar 

  • Comer SD, Hart CL, Ward AS, Haney M, Foltin RW, Fischman MW (2001) Effects of repeated oral methamphetamine administration in humans. Psychopharmacology (Berl) 155:397-404

    Article  CAS  Google Scholar 

  • Couper FJ, Pemberton M, Jarvis A, Hughes M, Logan BK (2002) Prevalence of drug use in commercial tractor-trailer drivers. J Forensic Sci 47:562–567

    PubMed  Google Scholar 

  • Crowley SJ, Lee C, Tseng CY, Fogg LF, Eastman CI (2004) Complete or partial circadian re-entrainment improves performance, alertness, and mood during night-shift work. Sleep 27:1077–1087

    PubMed  Google Scholar 

  • de Wit H, Uhlenhuth EH, Johanson CE (1985) Drug preference in normal volunteers: effects of age and time of day. Psychopharmacology (Berl) 87:186–193

    Article  Google Scholar 

  • Doty P, de Wit H (1995) Effect of setting on the reinforcing and subjective effects of ethanol in social drinkers. Psychopharmacology (Berl) 118:19–27

    Article  CAS  Google Scholar 

  • Eastman CI, Martin SK (1999) How to use light and dark to produce circadian adaptation to night shift work. Ann Med 31:87–98

    Article  CAS  PubMed  Google Scholar 

  • Foltin RW, Fischman MW, Brady JV, Kelly TH, Bernstein DJ, Nellis MJ (1989) Motivational effects of smoked marijuana: behavioral contingencies and high-probability recreational activities. Pharmacol Biochem Behav 34:871–877

    Article  CAS  PubMed  Google Scholar 

  • Fransen M, Wilsmore B, Winstanley J, Woodward M, Grunstein R, Ameratunga S, Norton R (2006) Shift work and work injury in the New Zealand Blood Donors’ Health Study. Occup Environ Med 63:352–358

    Article  CAS  PubMed  Google Scholar 

  • Gold DR, Rogacz S, Bock N, Tosteson TD, Baum TM, Speizer FE, Czeisler CA (1992) Rotating shift work, sleep, and accidents related to sleepiness in hospital nurses. Am J Public Health 82:1011–1014

    Article  CAS  PubMed  Google Scholar 

  • Hakkanen H, Summala H (2000) Sleepiness at work among commercial truck drivers. Sleep 23:49–57

    CAS  PubMed  Google Scholar 

  • Haney M, Ward AS, Comer SD, Hart CL, Foltin RW, Fischman MW (2001) Bupropion SR worsens mood during marijuana withdrawal in humans. Psychopharmacology (Berl) 155:171–179

    Article  CAS  Google Scholar 

  • Hart CL, Ward AS, Haney M, Foltin RW, Fischman MW (2001) Methamphetamine self-administration by humans. Psychopharmacology (Berl) 157:75–81

    Article  CAS  Google Scholar 

  • Hart CL, Ward AS, Haney M, Foltin RW (2003a) Zolpidem-related effects on performance and mood during simulated night-shift work. Exp Clin Psychopharmacol 11:259–268

    Article  CAS  PubMed  Google Scholar 

  • Hart CL, Ward AS, Haney M, Nasser J, Foltin RW (2003b) Methamphetamine attenuates disruptions in performance and mood during simulated night-shift work. Psychopharmacology (Berl) 169:42–51

    Article  CAS  Google Scholar 

  • Hart CL, Haney M, Nasser J, Foltin RW (2005) Combined effects of methamphetamine and zolpidem on performance and mood during simulated night shift work. Pharmacol Biochem Behav 81:559–568

    Article  CAS  PubMed  Google Scholar 

  • Hart CL, Haney M, Vosburg SK, Comer SD, Gunderson E, Foltin RW (2006) Modafinil attenuates disruptions in cognitive performance during simulated night-shift work. Neuropsychopharmacology 31:1526–1536

    Article  CAS  PubMed  Google Scholar 

  • Johanson CE, de Wit H (1992) Lack of effect of social context on the reinforcing effects of diazepam in humans. Pharmacol Biochem Behav. 43:463–469

    Article  CAS  PubMed  Google Scholar 

  • Jones HE, Garrett BE, Griffiths RR (2001) Reinforcing effects of oral cocaine: contextual determinants. Psychopharmacology (Berl) 154:143–152

    Article  CAS  Google Scholar 

  • Kelly TH, Foltin RW, Emurian CS, Fischman MW (1993) Performance-based testing for drugs of abuse: dose and time profiles of marijuana, amphetamine, alcohol, and diazepam. J Anal Toxicol 17:264–272

    CAS  PubMed  Google Scholar 

  • Kelly TH, Foltin RW, Mayr MT, Fischman MW (1994) Effects of delta 9-tetrahydrocannabinol and social context on marijuana self-administration by humans. Pharmacol Biochem Behav 49:763–768

    Article  CAS  PubMed  Google Scholar 

  • McLeod DR, Griffiths RR, Bigelow GE, Yingling J (1982) An automated version of the digit symbol substitution test (DSST). Behav Res Meth Instr 14:463–466

    Google Scholar 

  • McMenamin TM (2007) A time to work: recent trends in shift work and flexible schedules. Mon Labor Rev 120(12):3–15

    Google Scholar 

  • Miller TP, Taylor JL, Tinklenberg JR (1988) A comparison of assessment techniques measuring the effects of methylphenidate, secobarbital, diazepam and diphenhydramine in abstinent alcoholics. Neuropsychobiology 19:90–96

    Article  CAS  PubMed  Google Scholar 

  • Muehlbach MJ, Walsh JK (1995) The effects of caffeine on simulated night-shift work and subsequent daytime sleep. Sleep 18:22–29

    CAS  PubMed  Google Scholar 

  • Ohayon MM, Lemoine P, Arnaud-Briant V, Dreyfus M (2002) Prevalence and consequences of sleep disorders in a shift worker population. J Psychosom Res 53:577–583

    Article  PubMed  Google Scholar 

  • Perez A, Kirkpatrick MG, Gunderson EW, Marrone G, Silver R, Foltin RW, Hart CL (2008) Residual effects of intranasal methamphetamine on sleep, mood, and performance. Drug Alcohol Depend 94:258–262

    Article  CAS  PubMed  Google Scholar 

  • Reid K, Dawson D (2001) Comparing performance on a simulated 12 hour shift rotation in young and older subjects. Occup Environ Med 58:58–62

    Article  CAS  PubMed  Google Scholar 

  • Sharkey KM, Fogg LF, Eastman CI (2001) Effects of melatonin administration on daytime sleep after simulated night shift work. J Sleep Res 10:181–192

    Article  CAS  PubMed  Google Scholar 

  • Silverman K, Kirby KC, Griffiths RR (1994a) Modulation of drug reinforcement by behavioral requirements following drug ingestion. Psychopharmacology (Berl) 114:243–247

    Article  CAS  Google Scholar 

  • Silverman K, Mumford GK, Griffiths RR (1994b) Enhancing caffeine reinforcement by behavioral requirements following drug ingestion. Psychopharmacology (Berl) 114:424–432

    Article  CAS  Google Scholar 

  • Smith A (2002) Effects of caffeine on human behavior. Food Chem Toxicol 40:1243–1255

    Article  CAS  PubMed  Google Scholar 

  • Stoops WW, Lile JA, Fillmore MT, Glaser PE, Rush CR (2005a) Reinforcing effects of methylphenidate: influence of dose and behavioral demands following drug administration. Psychopharmacology (Berl) 177:349–355

    Article  CAS  Google Scholar 

  • Stoops WW, Lile JA, Fillmore MT, Glaser PE, Rush CR (2005b) Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration. Psychopharmacology (Berl) 182:186–193

    Article  CAS  Google Scholar 

  • Substance Abuse and Mental Health Services Administration (SAMHSA) (2007) Office of Applied Studies. Treatment Episode Data Set (TEDS) Highlights—2006 National Admissions to Substance Abuse Treatment Services. OAS Series #S-40, DHHS Publication No. (SMA) 08-4313, Rockville, MD

  • U.S. Congress, Office of Technology Assessment (1991) Biological rhythms: implications for the worker. US Government Printing Office, Washington

    Google Scholar 

  • Walsh JK, Muehlbach MJ, Humm TM, Dickins QS, Sugerman JL, Schweitzer PK (1990) Effect of caffeine on physiological sleep tendency and ability to sustain wakefulness at night. Psychopharmacology (Berl) 101:271–273

    Article  CAS  Google Scholar 

  • Wesnes K, Warburton DM (1983) Effects of smoking on rapid information processing performance. Neuropsychobiology 9:223–229

    Article  CAS  PubMed  Google Scholar 

  • Wiegmann DA, Stanny RR, McKay DL, Neri DF, McCardie AH (1996) Methamphetamine effects on cognitive processing during extended wakefulness. Int J Aviat Psychol 6:379–397

    Article  CAS  PubMed  Google Scholar 

  • Williamson A (2007) Predictors of psychostimulant use by long-distance truck drivers. Am J Epidemiol 166:1320–1326

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The medical assistance of Drs. Evaristo Akerele, Anthony J. Tranguch, Vladimir Ginzburg, and Jeffrey Wilson and the technical assistance of Christine Figueroa, Susan Loftus, Brooke Roe, and Mabel Torres are gratefully acknowledged. This research was supported by grant number DA-03746 from the National Institute on Drug Abuse.

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Authors and Affiliations

  1. Department of Psychology, Columbia University, New York, USA

    Matthew G. Kirkpatrick & Carl L. Hart

  2. Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY, 10032, USA

    Matthew G. Kirkpatrick, Margaret Haney, Suzanne K. Vosburg, Sandra D. Comer, Richard W. Foltin & Carl L. Hart

  3. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, USA

    Matthew G. Kirkpatrick, Margaret Haney, Suzanne K. Vosburg, Sandra D. Comer, Richard W. Foltin & Carl L. Hart

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  1. Matthew G. Kirkpatrick
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  2. Margaret Haney
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  3. Suzanne K. Vosburg
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  4. Sandra D. Comer
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  5. Richard W. Foltin
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  6. Carl L. Hart
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Correspondence to Carl L. Hart.

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Kirkpatrick, M.G., Haney, M., Vosburg, S.K. et al. Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes. Psychopharmacology 203, 771–780 (2009). https://doi.org/10.1007/s00213-008-1423-1

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  • DOI: https://doi.org/10.1007/s00213-008-1423-1

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