Abstract
Rationale
It is not clear how the deleterious effects of amphetamines on driving performance are mediated in terms of select cognitive processes.
Objectives
The current three separate experiments assessed the acute effects of an oral dose of either 0.42-mg/kg d-amphetamine, d,l-methamphetamine and d-methamphetamine on driving-related cognitive functions in a total of 60 healthy non-fatigued adults.
Materials and methods
Three separate repeated measures counterbalanced, double-blind, placebo-controlled designs were employed in which 20 volunteers completed two treatment conditions, either d-amphetamine, d,l-methamphetamine or d-methamphetamine and placebo. Performance was assessed on a range of attentional, psychomotor and perceptual speed tasks.
Results
Mean blood concentrations at 120-, 170- and 240-min postdrug administration were 83, 98 and 96 ng/ml, respectively, for d-amphetamine, 90, 95 and 105 ng/ml, respectively, for d,l-methamphetamine and 72, 67 and 59 ng/ml, respectively, for d-methamphetamine. The amphetamines, in general, improved various aspects of attention (Digit Vigilance, Digit Symbol Substitution Test and Movement Estimation Performance) with some evidence to suggest possible enhancement in psychomotor functioning (Tracking ability) and perceptual speed (Inspection Time).
Conclusions
The current series of studies primarily provides evidence of low-level amphetamine-related enhancement of function; however, it also provides evidence of less conservative movement estimation that might contribute to amphetamine-related road fatalities.
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References
Angrist B, Corwin J, Bartlik B, Cooper T (1987) Early pharmacokinetics and clinical effects of oral d-amphetamine in normal subjects. Biol Psychiatry 22:1357–1368
Asghar SJ, Tanay VAMI, Baker GB, Greenshaw A, Silverstone PH (2003) Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers. Hum Psychopharmacol 18:291–299
Baddeley A, Logie R (1986) Dementia and working memory. Q J Exp Psychol 38:603–618
Bakshi VP, Geyer MA, Taaid N, Swerdlow NR (1995) A comparison of the effects of amphetamine, strychnine and caffeine on prepulse inhibition and latent inhibition. Behav Pharmacol 6:801–809
Barch DM, Carter CS (2005) Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers. Schizophr Res 77(1):43–58
Belleville JP, Dorey F, Bellville JW (1979) Effects of nefopam on visual tracking. Clin Pharmacol Ther 26(4):457–463
Blumenthal TD, Schicatano EJ, Chapman JG, Norris CM, Ergenzinger ER (1996) Prepulse effects on magnitude estimation of startle-eliciting stimuli and startle responses. Percept Psychophys 58(1):73–80
Brauer LH, Ambre J, de Wit H (1996) Acute tolerance to subjective but not cardiovascular effects of d-amphetamine in normal healthy men. J Clin Psychopharmacol 16(1):72–76
Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D (1997) Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc Natl Acad Sci 94(6):2569–2574
Cami J, Farre M, Mas M, Roset P, Poudevida S, Mas A, San L, de la Torre R (2000) Human pharmacology of 3,4-methylenedioxymeth-amphetamine (“Ecstasy”): psychomotor performance and subjective effects. J Clin Psychopharmacol 20(4):455–466
Comer SD, Haney M, Foltin RW, Fischman MW (1996) Amphetamine self-administration by humans: modulation by contingencies associated with task performance. Psychopharmacology 127:39–46
Comer SD, Hart CL, Ward AS, Haney M, Foltin RW, Fischman MW (2001) Effects of repeated oral methamphetamine administration in humans. Psychopharmacology 155:397–404
de Wit H, Crean J, Richards JB (2000) Effects of d-amphetamine and ethanol on a measure of behavioural inhibition in humans. Behav Neurosci 114(4):830–837
de Wit H, Enggasser JL, Richards JB (2002) Acute administration of d-amphetamine decreases impulsivity in healthy volunteers. Neuropsychopharmacology 27(5):813–825
Deary IJ, Stough C (1996) Intelligence and inspection time: achievements, prospects, and problems. Am Psychol 51(6):599–608
Drevets WC, Gautier C, Price JC, Kupfer DJ, Kinahan PE, Grace AA, Price JL, Mathis CA (2001) Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol Psychiatry 49(2):81–96
Drummer OH, Gerostamoulos J, Batziris H, Chu M, Caplehorn JRM, Robertson MD, Swann P (2003a) The incidence of drugs in drivers killed in Australian road traffic crashes. Forensic Sci Int 134:154–162
Drummer OH, Gerostamoulos J, Batziris H, Chu M, Caplehorn J, Robertson MD, Swann P (2003b) The involvement of drugs in drivers of motor vehicles killed in Australian road traffic crashes. Accident Anal Prev 943:1–10
Easterbrook JA (1959) The effect of emotion on cue utilization and the organisation of behaviour. Psychol Rev 66(3):183–201
Feldman RS, Meyer JS, Quenzer LF (1997) Principles of neuropsychopharmacology, Sinauer, Sunderland, Massachusetts
Fillmore MT, Kelly TH, Martin CA (2005) Effects of d-amphetamine in human models of information processing and inhibitory control. Drug Alcohol Depend 77:151–159
Fleming K, Bigelow LB, Weinberger DR, Goldberg TE (1995) Neuropsychological effects of amphetamine may correlate with personality characteristics. Psychopharmacol Bull 31(2):357–362
Foltin RW, Evans SM (1993) Performance effects of drugs of abuse: a methodological survey. Hum Psychopharmacol 8:9–19
Giovagnoli AR, Del Pesce M, Mascheroni S, Simonceli M, Laiacona M, Captitani E (1996) Trail making test: normative values from 287 normal adult controls. Ital J Neurol Sci 17(4):305–309
Halliday R, Naylor H, Brandeis D, Callaway E, Yano L, Herzig K (1994) The effect of d-amphetamine, clonidine, and yohimbine on human information processing. Psychophysiology 31:331–337
Hurst PM (1962) The effects of d-amphetamine on risk taking. Psychopharmacologia 3:283–290
Hurst PM (1987) Amphetamines and driving. Alcohol Drugs Driv 3(1):13–16
Hurst PM, Weidner MF, Radlow R (1967) The effects of amphetamines upon judgement and decisions. Psychopharmacologia 1(5):397–404
Hutchison KE, Swift R (1999) Effect of d-amphetamine on prepulse inhibition of the startle reflex in humans. Psychopharmacology 143:394–400
Johnson BA, Ait-Daoud N, Wells LT (2000) Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on d-methamphetamine-induced cognitive and physiological changes in humans. Neuropsychopharmacology 22(5):504–512
Kelly TH, Foltin RW, Fischman MW (1991) The effects of repeated amphetamine exposure on multiple measures of human behaviour. Pharmacol Biochem Behav 38:417–426
Kelly TH, Foltin RW, Emurian CS, Fischman MW (1993) Performance-based testing for drugs of abuse: dose and time profiles of marijuana, amphetamine, alcohol, and diazepam. J Anal Toxicol 17:264–272
Kennedy RS, Odenheimer RC, Baltzley DR, Dunlap WP, Wood CD (1990) Differential effects of scopolamine and amphetamine on microcomputer-based performance tests. Aviat Space Environ Med 61(7):615–621
Koelega HS (1993) Stimulant drugs and vigilance performance: a review. Psychopharmacology 111:1–16
Kumari V, Corr PJ, Mulligan OF, Cotter PA, Checkley SA, Gray JA (1997) Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man. Psychopharmacology 129:271–276
Kumari V, Mulligan OF, Cotter PA, Poon L, Toone BK, Checkley SA, Gray JA (1998) Effects of single oral administrations of haloperidol and d-amphetamine on prepulse inhibition of the acoustic startle reflex in healthy male volunteers. Behav Pharmacol 9:567–576
Kupietz SS, Bartlik B, Angrist B, Winsberg BG (1985) Psychostimulant plasma concentration and learning performance. J Clin Psychopharmacol 5(5):293–295
Lamers CTJ, Ramaekers JG, Muntejewerff ND, Sikkema KL, Samyn N, Read NL, Brookhuis KA, Riedal WJ (2003) Dissociable effects of a single dose of ecstasy (MDMA) on psychomotor skills and attentional performance. J Psychopharmacol 17(4):379–387
Laruelle M, Abi-Dargham A, van Dyck CH, Rosenblatt W, Zea-Ponce Y, Zoghbi SS, Baldwin RM, Charney DS, Hoffer PB, Kung HF (1995) SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med 36(7):1182–1190
Logan BK (1996) Methamphetamine and driving impairment. J Forensic Sci 41(3):457–464
Logan BK (2002) Methamphetamine—effects on human performance and behaviour. Forensic Sci Rev 14(1/2):133–151
Logan BK, Fligner CL, Haddix T (1998) Cause and manner of death in fatalities involving methamphetamine. J Forensic Sci 43(1):28–34
Magill RA, Waters WF, Bray GA, Volaufova J, Smith SR, Lieberman HR, McNevin N, Ryan DH (2003) Effects of tyrosine, phentermine, caffeine, d-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. Nutr Neurosci 6(4):237–246
Mattay VS, Callicott JH, Bertolino A, Heaton I, Frank JA, Coppola R, Berman KF, Goldberg TE, Weinberger DR (2000) Effects of dextroamphetamine on cognitive performance and cortical activation. NeuroImage 12:268–275
McKetin R, Ward PB, Catts SV, Mattick RP, Bell JR (1999) Changes in auditory selective attention and event-related potentials following oral administration of d-amphetamine in humans. Neuropsychopharmacology 21(3):380–390
McNair DM, Lorr M, Droppleman LF (1992) Profile of mood states revised manual. Edits/Educational and Industrial Testing Service, San Diego, California
Mills KC, Parkman KM, Smith GA, Rosendahl F (1999) Prediction of driving performance through computerized testing: high-risk driver assessment and training. Transp Res Rec 1689:18–24
Mills KC, Spruill SE, Kanne RW, Parkman KM, Zhang Y (2001) The influence of stimulants, sedatives, and fatigue on tunnel vision: risk factors for driving and piloting. Hum Factors 43(2):310–327
Moeller MR, Kraemer T (2002) Drugs of abuse monitoring in blood for control of driving under the influence of drugs. Ther Drug Monit 24:210–221
Pickworth WB, Rohrer MS, Fant RV (1997) Effects of abused drugs on psychomotor performance. Exp Clin Psychopharmacol 5(3):235–241
Rapoport JL, Buchsbaum MS, Weingertner H (1980) Dextroamphetamine: cognitive and behavioural effects in normal and hyperactive boys and normal adult males. Psychopharmacol Bull 16(1):21–23
Read NL, Ward NJ, Parkes AM (2000) The role of dynamic tests in assessing the fitness to drive of healthy and cognitively impaired elderly. J Traffic Med 28:34S–35S
Silber BY, Papafotiou K, Croft RJ, Ogden E, Swann P, Stough C (2005) The effects of dexamphetamine on simulated driving performance. Psychopharmacology 179:536–543
Solomon PR, Crider A, Winkelman JW, Turi A, Kamer RM, Kaplan LJ (1981) Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity: relationship to schizophrenic attention disorder. Biol Psychiatry 16:519–537
Swerdlow NR (1996) Cortico-striatal substrates of cognitive, motor and sensory gating: speculations and implications for psychological function and dysfunction. In: Panksepp J (ed) Advances in biological psychiatry, vol. 2. JAI, Greenwich, Conn, pp 179–208
Swerdlow NR, Geyer MA (1998) Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull 24(2):285–301
Swerdlow NR, Stephany N, Wasserman LC, Talledo J, Shoemaker J, Auerbach PP (2003) Amphetamine effects on prepulse inhibition across-species: replication and parametric extension. Neuropsychopharmacology 28:640–650
Traffic Accident Commission (TAC), Victoria, Australia (2005) http://www.tacsafety.com.au/jsp/homepage/homejsp
Wachtel SR, de Wit H (1999) Subjective and behavioural effects of repeated d-amphetamine in humans. Behav Pharmacol 10:271–281
Ward AS, Kelly TH, Foltin RW, Fischman MW (1997) Effects of d-amphetamine on task performance and social behaviour of humans in a residential laboratory. Exp Clin Psychopharmacol 5(2):130–136
Ward N, Dye L, Dobson P, Read NL (2000) The effect of chronic cannabis consumption on time estimation and reproduction: implications for driving performance. In: Siedel H (ed) Proceedings of the ICADTS 2000 ICADTS, Stockhom
Wechsler D (1997) WAIS-III administration and scoring manual. The psychological cooperation, San Antonio, Texas
Weiner I, Lubow RE, Feldon J (1988) Disruption of latent inhibition by acute administration of low doses of amphetamine. Pharmacol Biochem Behav 30:871–878
Wesnes KA, Simpson PM, Christmas L, Anand R, McClelland GR (1989) The effects of moclobemide on cognition. J Neural Transm Suppl 28:91–102
Williams LJ (1988) Tunnel vision or general interference? Cognitive load and attentional bias are both important. Am J Psychol 101(2):171–191
Williams LJ (1995a) Peripheral target recognition and visual field narrowing in aviators and nonaviators. Int J Aviat Psychol 5(2):215–232
Williams LJ (1995b) Visual field tunneling in aviators induced by memory demands. J Gen Psych 122(2):225–235
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This research was funded by a grant from VicRoads, Melbourne, Australia.
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Silber, B.Y., Croft, R.J., Papafotiou, K. et al. The acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance. Psychopharmacology 187, 154–169 (2006). https://doi.org/10.1007/s00213-006-0410-7
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DOI: https://doi.org/10.1007/s00213-006-0410-7