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Revisiting the ethnomedicinal, ethnopharmacological, phytoconstituents and phytoremediation of the plant Solanum viarum Dunal

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Abstract

Solanum viarum, a perennial shrub, belongs to the family Solanaceae known for its therapeutic value worldwide. As a beneficial remedial plant, it is used for treating several disorders like dysentery, diabetes, inflammation, and respiratory disorders. Phytochemistry studies of this plant have shown the presence of steroidal glycoside alkaloids, including solasonine, solasodine, and solamargine. It also has flavonoids, saponins, minerals, and other substances. S. viarum extracts and compounds possess a variety of pharmacological effects, including antipyretic, antioxidant, antibacterial, insecticidal, analgesic, and anticancer activity. Most of the heavy metals accumulate in the aerial sections of the plant which is considered a potential phytoremediation, a highly effective method for the treatment of metal-polluted soils. We emphasize the forgoing outline of S. viarum, as well as its ethnomedicinal and ethnopharmacological applications, the chemistry of its secondary metabolites, and heavy metal toxicity. In addition to describing the antitumor activity of compounds and their mechanisms of action isolated from S. viarum, liabilities are also explained and illustrated, including any significant chemical or metabolic stability and toxicity risks. A comprehensive list of information was compiled from Science Direct, PubMed, Google Scholar, and Web of Science using different key phrases (traditional use, ethnomedicinal plants, western Himalaya, Himachal Pradesh, S viarum, and biological activity). According to the findings of this study, we hope that this review will inspire further studies along the drug discovery pathway of the chemicals extracted from the plant of S. viarum. Further, this review shows that ethnopharmacological information from ethnomedicinal plants can be a promising approach to drug discovery for cancer and diabetes.

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Acknowledgements

The authors acknowledge the support of Chancellor, Shoolini University, India, for extending the facilities in completing this work.

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Authors and Affiliations

  1. School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India

    Mehak Thakur, Rachna Verma & Rajni Dhalaria

  2. School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India

    Dinesh Kumar

  3. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, 173229, India

    Priyanku Pradip Das & Deepak Kumar

  4. ICFRE-Himalayan Forest Research Institute, Shimla, Himachal Pradesh, 171013, India

    Ajay Kumar

  5. Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003, Hradec Kralove, Czech Republic

    Rachna Verma & Kamil Kuca

  6. Faculty of Life Sciences, Pharmaceutical Technical University, 100084, Tashkent, Uzbekistan

    Shavkatjon Azizov

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Contributions

M. T.: investigation, writing—original draft. R. D., P. P. D., and A. K.: contributed to making the figures and providing the literature. D. K., K. K., and S. A.: validation, visualization, writing—original draft, review and editing. R. V.: supervision, conceptualization, review and editing. Deepak Kumar: conceptualization, review and editing. All the authors have read and approved the final manuscript. The authors confirm that no paper mill and artificial intelligence was used.

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Thakur, M., Verma, R., Kumar, D. et al. Revisiting the ethnomedicinal, ethnopharmacological, phytoconstituents and phytoremediation of the plant Solanum viarum Dunal. Naunyn-Schmiedeberg's Arch Pharmacol (2024). https://doi.org/10.1007/s00210-024-03034-6

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