Abstract
In this study, the anticancer activities of some pyrrolopyrimidine derivatives were evaluated. Compound 3 is the most cytotoxic compound on MCF-7 cancer cells with an IC50 value of 23.42 µM. Also, compound 3 induced apoptosis and the ROS(+) cell population in MCF-7 cells. Moreover, it significantly reduced MMP-9 activity, having 42.16 ± 5.10% and 58.28 ± 1.96% inhibitory activities at 10 µM and 50 µM concentrations, respectively. Molecular docking results supported the activity, showing key hydrogen bonds with the binding site of MMP-9. Therefore, compound 3 might be a lead compound for the development of potent MMP-9 inhibitors.
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The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
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This work was supported by Ankara University Scientific Research Council of Ankara University with 18H0237006 project number.
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ZKK and FBA conceived and the designed research. ZKK, FBA, and AC conducted experiments. FBA and AC analyzed data. ZKK and FBA wrote the manuscript. All authors read and approved the manuscript. The authors declare that all data were generated in-house and that no paper mill was used.
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Kilic-Kurt, Z., Celik, A. & Bakar-Ates, F. Effects of pyrrolopyrimidine derivatives on cancer cells cultured in vitro and potential mechanism. Naunyn-Schmiedeberg's Arch Pharmacol 397, 3169–3177 (2024). https://doi.org/10.1007/s00210-023-02799-6
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DOI: https://doi.org/10.1007/s00210-023-02799-6