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Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies

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Abstract

One of the well-studied older molecules, quercetin, is found in large quantities in many fruits and vegetables. Natural anti-oxidant quercetin has demonstrated numerous pharmacological properties in preclinical and clinical research, including anti-inflammatory and anti-cancer effects. Due to its ability to control cell signaling pathways, including NF-κB, p53, activated protein-1 (AP-1), STAT3, and epidermal growth response-1 (Egr-1), which is essential in the initiation and proliferation of cancer, it has gained a lot of fame as an anticancer molecule. Recent research suggests that using nanoformulations can help quercetin to overcome its hydrophobicity while also enhancing its stability and cellular bioavailability both in vitro and in vivo. The main aim of this review is to focus on the comprehensive insights of several nanoformulations, including liposomes, nano gels, micelles, solid lipid nanoparticles (SLN), polymer nanoparticles, gold nanoparticles, and cyclodextrin complexes, to transport quercetin for application in cancer.

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Acknowledgements

Dr. T.S., would like to acknowledge ICMR-DHR, Government of India (ICMR-DHR Young Scientist Fellowship, F.NO: R. 12014/29/2022/HR), and college Research and Development Cell (RDC) Scheme (File no. HRC/RDC/2021/RP/13). We would also like to acknowledge Dr. Hadi Sajid Abdulabbas for his general help in this manuscript.

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Authors and Affiliations

  1. School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India

    Hemant Joshi

  2. Department of Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Vile Parle-West, Mumbai, 400056, India

    Dhruv Sanjay Gupta & Ginpreet Kaur

  3. Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi, 110007, India

    Tejveer Singh

  4. University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali, 140413, India

    Seema Ramniwas

  5. NGO Praeventio, Tartu, Estonia

    Katrin Sak

  6. Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, 133207, India

    Diwakar Aggarwal, Adesh K. Saini & Hardeep Singh Tuli

  7. Tech Mahindra, Mumbai, Maharashtra, 400072, India

    Raunak Singh Chhabra

  8. Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, 110017, India

    Madhu Gupta

  9. Faculty of Agriculture, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, 133207, India

    Adesh K. Saini

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Contributions

H.S.T., H.J., D.S.G., G.K., T.S., S.R., K.S., and D.A. conceived the conceptualization, methodology, validation, and writing—review. M.G. and H.S.T. performed the formal analysis and resources. A.K.S. did the data curation and editing. R.S.C. contributed to revise the manuscript. All authors have read and agreed to the published version of the manuscript. The authors confirm that no paper mill and artificial intelligence was used.

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Correspondence to Hardeep Singh Tuli.

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Joshi, H., Gupta, D.S., Kaur, G. et al. Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies. Naunyn-Schmiedeberg's Arch Pharmacol 396, 3443–3458 (2023). https://doi.org/10.1007/s00210-023-02625-z

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  • DOI: https://doi.org/10.1007/s00210-023-02625-z

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