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Chemopreventive mechanisms of amentoflavone: recent trends and advancements

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Abstract

In parallel to the continuous rise of new cancer cases all over the world, the interest of scientific community in natural anticancer agents has steadily been increased. In the past decades, numerous phytochemicals have been shown to possess a strong anticancer potential in preclinical conditions. One of such interesting compounds, derived from different plants such as ginkgo, hinoki, and St. John`s wort, is amentoflavone. In this review article, a wide range of anticancer properties of this natural biflavone are described, revealing its ability to suppress the malignant growth and lead tumor cells to apoptotic death, besides impeding also angiogenic and metastatic processes. Therefore, amentoflavone can be considered a potential lead compound for the development of novel anticancer drug candidates, definitely deserving further in vivo studies and also initiation of clinical trials. It is expected that this plant biflavone might be important, either alone or in combination with the current standard chemotherapeutics, in providing some alleviation for the continuous rise of global cancer burden.

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Data availability

This document includes citations for all the data that were analyzed throughout the literature review.

Abbreviations

IARC :

International Agency for Research on Cancer

AF :

Amentoflavone

DMSO :

Dimethyl sulphoxide

COX-2 :

Cyclooxygenase-2

iNOS :

Inducible nitric oxide synthase

PPARγ :

Peroxisome proliferator–activated receptor gamma

PTEN :

Phosphatase and tensin homolog

ROS :

Reactive oxygen species

AMPK :

5'AMP-activated protein kinase

mTOR :

Mammalian target of rapamycin

DNMT1 :

DNA methyltransferase-1

C-FLIP :

Cellular FLICE-like inhibitory protein

Mcl-1 :

Myeloid cell leukemia 1

XIAP :

X-linked inhibitor of apoptosis

AIF :

Apoptosis-inducing factor

VEGF :

Vascular endothelial growth factor

MMP-2 :

Matrix metalloproteinase-2

ERK :

Extracellular signal-regulated kinase

MAPK :

Mitogen activated protein kinase

TNF-α :

Tumor necrosis factor-alpha

IL-6 :

Interleukin-6

EMT :

Epithelial mesenchymal transition

PI3K :

Phosphatidylinositide 3-kinase

MPP :

1-Methyl-4-phenylpyridinium

NLRP3 :

NOD-like receptor protein 3

LPS :

Lipopolysaccharide

RNS :

Reactive nitrogen species

MDA :

Malondialdehyde

AKR1B10 :

Aldo-keto reductase family 1B10

PARP-1 :

Poly [ADP-ribose] polymerase 1

ADMET :

Absorption, distribution, metabolism, excretion, and transportation

TBESD :

Total bioflavonoids extract from Selaginella doederleinii

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Authors and Affiliations

  1. Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Ambala, Mullana, 133207, India

    Hardeep Singh Tuli

  2. School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India

    Hemant Joshi

  3. Advance Cardiac Centre Department of Cardiology, Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh, Chandigarh, 160012, India

    Kanupriya Vashishth

  4. University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Mohali, 140413, India

    Seema Ramniwas

  5. Department of Molecular Biology and Genetics, Faculty of Science, Mugla Sitki Kocman University, Mugla, Turkey

    Mehmet Varol

  6. Department of Chemistry, Maharishi Markandeshwar University Sadopur, Ambala, 134007, India

    Manoj Kumar

  7. Department of Biochemistry, Maharishi Markandeshwar College of Medical Sciences and Research (MMCMSR), Sadopur, 134007, Ambala, India

    Isha Rani

  8. Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307, Uttar Pradesh, India

    Vibha Rani

  9. NGO Praeventio, 50407, Tartu, Estonia

    Katrin Sak

Authors
  1. Hardeep Singh Tuli
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  2. Hemant Joshi
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  3. Kanupriya Vashishth
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  4. Seema Ramniwas
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  5. Mehmet Varol
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  6. Manoj Kumar
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  7. Isha Rani
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  8. Vibha Rani
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  9. Katrin Sak
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Contributions

Conceptualization, methodology, validation, writing—review, H.S.T., H.J., K.V., S.R., M.V. and K.S.; formal analysis, resources, M.K., and I.R.; data curation, V.R.; all authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Katrin Sak.

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Tuli, H.S., Joshi, H., Vashishth, K. et al. Chemopreventive mechanisms of amentoflavone: recent trends and advancements. Naunyn-Schmiedeberg's Arch Pharmacol 396, 865–876 (2023). https://doi.org/10.1007/s00210-023-02416-6

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