Abstract
Cisplatin is an effective chemotherapeutic drug widely used for the treatment of various solid tumors; however, its clinical use and efficacy are limited by its inherent nephrotoxicity. The pathogenesis of cisplatin-induced nephrotoxicity is complex and has not been fully elucidated. Cellular uptake and transport, DNA damage, apoptosis, oxidative stress, inflammatory response, and autophagy are involved in the development of cisplatin-induced nephrotoxicity. Currently, despite some deficiencies, hydration regimens remain the major protective measures against cisplatin-induced nephrotoxicity. Therefore, effective drugs must be explored and developed to prevent and treat cisplatin-induced kidney injury. In recent years, many natural compounds with high efficiency and low toxicity have been identified for the treatment of cisplatin-induced nephrotoxicity, including quercetin, saikosaponin D, berberine, resveratrol, and curcumin. These natural agents have multiple targets, multiple effects, and low drug resistance; therefore, they can be safely used as a supplementary regimen or combination therapy for cisplatin-induced nephrotoxicity. This review aimed to comprehensively describe the molecular mechanisms underlying cisplatin-induced nephrotoxicity and summarize natural kidney-protecting compounds to provide new ideas for the development of better therapeutic agents.
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Acknowledgements
We thank Zhaowei Zhang for editorial assistance in the preparation of the manuscript.
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This study was financially supported by the National Natural Science Foundation of China (No. 82003755) and the Initial Scientific Research Foundation for Jinhua Municipal Central Hospital (No. JY2019-2-01).
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X.B. and L.H. provided the ideas for this review; D.Z., K.J., G.L., and J.K. wrote the manuscript; G.L. designed and supervised the manuscript writing. All authors have read and approved to the published version of the manuscript. The authors confirm that no paper mill and artificial intelligence was used.
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Zhang, D., Luo, G., Jin, K. et al. The underlying mechanisms of cisplatin-induced nephrotoxicity and its therapeutic intervention using natural compounds. Naunyn-Schmiedeberg's Arch Pharmacol 396, 2925–2941 (2023). https://doi.org/10.1007/s00210-023-02559-6
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DOI: https://doi.org/10.1007/s00210-023-02559-6