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Antimicrobial peptides as potential therapy for gastrointestinal cancers

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Abstract

Since conventional therapy faces limitations in the field of different cancers as well as gastrointestinal cancers, that decrease the survival rate of patients, there is an urgent need to find new effective therapeutic approaches without the adverse effects of the traditional agents. Antimicrobial peptides (AMPs) attract much attention and are well known for their role in innate immunity. These peptides, in addition to their antimicrobial activity, exhibit strong anticancer potential against various types of malignancy. AMPs specifically target tumor cells and have selective toxicity for these cells without affecting normal cells. Here we aim to comprehensively overview the current knowledge in the field of using AMPs as novel therapeutic agents for gastrointestinal cancer.

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Authors and Affiliations

  1. Heping Hospital Attached to Changzhi Medical College, Changzhi, 046000, China

    Xiaoxia Yang & Zhao Ganting

  2. Tangshan Fengnan District Traditional Chinese Medicine Hospital, Tangshan, 063000, China

    Cui Hua

  3. Tangshan Hongci Hospital, Tangshan, 063000, China

    Lin Lin

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  1. Xiaoxia Yang
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  2. Cui Hua
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The first draft of the manuscript was written by X.Y., and L.L. and Z.G. commented and improved the manuscript. All authors collaborated and commented on previous versions of the manuscript. Finally, all authors read and approved the final manuscript. C.H, L.L. and Z.G. were responsible for coordinating the authors, finalized and submitted the paper. The authors confirm that no paper mill and artificial intelligence was used.

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Correspondence to Cui Hua.

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Yang, X., Hua, C., Lin, L. et al. Antimicrobial peptides as potential therapy for gastrointestinal cancers. Naunyn-Schmiedeberg's Arch Pharmacol 396, 2831–2841 (2023). https://doi.org/10.1007/s00210-023-02536-z

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  • DOI: https://doi.org/10.1007/s00210-023-02536-z

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