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Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population

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Abstract.

Catechol O-methyltransferase (COMT) inactivates neurotransmitters, catechol hormones and drugs such as levodopa and methyldopa. A low activity allele has been demonstrated at codon 108/158 of the soluble and membrane-bound COMT, respectively, whereby a G to A transition results in a valine to methionine substitution. Ethnic and inter-individual differences in red blood cell COMT activity have been observed in the different populations studied so far. Since, no information is available on inter-individual variability of COMT genotype in Turkish population, we genotyped 217 healthy, unrelated Turkish individuals. The allelic frequencies of COMT gene in the Turkish population were found to be the same as has been observed in Caucasians, but different from Orientals.

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Authors and Affiliations

  1. Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom-Ankara, Turkey, , , , ,

    Neslihan Kocabaş, Ali Karakaya & Şemra Şardaş

  2. Department of Pharmacological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle-upon-Tyne, NE2 4HH, UK, , , , ,

    Suzanne Cholerton

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  1. Neslihan Kocabaş
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  2. Ali Karakaya
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  3. Suzanne Cholerton
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  4. Şemra Şardaş
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Kocabaş, N., Karakaya, A., Cholerton, S. et al. Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population. Arch Toxicol 75, 407–409 (2001). https://doi.org/10.1007/s002040100252

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  • DOI: https://doi.org/10.1007/s002040100252

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