Abstract
Male CD-1 mice in groups of 52, 53 or 100 were administered piperonyl butoxide (α-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene) in the diet at levels of 0 (control), 0.6 and 1.2% for 12 months. Hepatocellular carcinoma was induced in treated groups in a dose-dependent manner but not in the control group. The incidences of hepatocellular carcinoma were 11.3 and 52.0% in mice given 0.6 and 1.2% piperonyl butoxide, indicating that piperonyl butoxide can cause hepatocellular carcinoma in mice as it is known to do in rats.
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This is an abridged report of the research conducted. We plan to report detailed results of the chronic toxicity study of male mice together with the data on females at a future time. This study was conducted equally by the five authors named, so that the order used here is of no consequence.
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Takahashi, O., Oishi, S., Fujitani, T. et al. Piperonyl butoxide induces hepatocellular carcinoma in male CD-1 mice. Arch Toxicol 68, 467–469 (1994). https://doi.org/10.1007/s002040050098
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DOI: https://doi.org/10.1007/s002040050098