Skip to main content
SpringerLink
Log in

Flavonoids commonly induce hormetic responses

  • Commentary
  • Published:
Archives of Toxicology Aims and scope Submit manuscript

Abstract

The present paper provides a new perspective of previously published findings by Siwak (Food Chem 141:1227–1241, 2013) which showed that 15 structurally diverse flavonoids reduced toxicity (i.e., enhanced cell viability) from hypochlorite using the MTT assay within a pre-conditioning experimental protocol, with each agent showing a similar biphasic concentration response relationship. We use this Commentary to point out that each of the concentration response relationships are consistent with the hormetic dose response. The paper of Siwak (Food Chem 141:1227–1241, 2013) is unique in that it provides a comparison of a relatively large number of agents using the identical experimental protocol.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Data availability

Not applicable.

References

  • Calabrese EJ, Agathokleous E (2022) Hormesis: transforming disciplines that rely on the dose response. IUBMB 74:8–23

    Article  CAS  Google Scholar 

  • Calabrese EJ, Baldwin LA (2001) The frequency of U-shaped dose responses in the toxicological literature. Toxicol Sci 62:330–338

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Baldwin LA (2003) Hormesis at the National Toxicology Program (NTP): evidence of hormetic dose responses in NTP dose-range studies. Nonlin Biol Toxicol Med 1:455–467

    Article  CAS  Google Scholar 

  • Calabrese EJ, Blain R (2011) The hormesis database: the occurrence of hormetic dose response in the toxicological literature. Reg Toxicol Pharm 61:73–81

    Article  CAS  Google Scholar 

  • Calabrese EJ, Mattson MP (2011) Hormesis provides a generalized quantitative estimate of biological plasticity. J Cell Comm Sign 5:25–38

    Article  Google Scholar 

  • Calabrese EJ, Mattson MP (2017) How does hormesis impact biology, toxicology, and medicine? NPJ Aging Mech Dis 3:13. https://doi.org/10.1038/s41514-017-0013-z

    Article  PubMed  PubMed Central  Google Scholar 

  • Calabrese EJ, Staudenmayer JW, Stanek EJ, Hoffmann GR (2006) Hormesis outperforms threshold model in National Cancer Institute antitumor drug screening database. Toxicol Sci 94:368–378

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Stanek EJ III, Nascarella MA, Hoffmann GR (2008) Hormesis predicts low-dose responses better than threshold models. Int J Toxicol 27:369–378

    Article  CAS  PubMed  Google Scholar 

  • Calabrese EJ, Dhawan G, Kapoor R, Agathokleous E, Calabrese V (2023a) Moringa induces its beneficial effects vis hormesis. Nutr Res Rev 4:1–37. https://doi.org/10.1017/S00954422423000161

    Article  Google Scholar 

  • Calabrese EJ, Dhawan G, Kapoor R, Agathokleous E, Calabrese V (2023b) Rhodiola rosea and salidroside commonly induce hormesis with particular focus on longevity and neuroprotection. Chem-Biol Inter 380:110540. https://doi.org/10.1016/j.cbi.2023

    Article  CAS  Google Scholar 

  • Calabrese EJ, Pressman P, Hayes AW, Dhawan G, Kapoor R, Agathokleous E, Manes PK (2023c) Naringin commonly acts via hormesis. Sci Total Environ 896:164728

    Article  ADS  CAS  PubMed  Google Scholar 

  • Giani F, Massto R, Trovato MA, Franco A, Pandini G, Vigneri R (2021) Thyroid stem cells but not differentiated thyrocytes are sensitive to slightly increased concentrations of heavy metals. Front Endocrin 12:652675

    Article  Google Scholar 

  • Siwak J, Lewinska A, Wnuk M, Bartosz G (2013) Protection of flavonoids against hypochlorite-induced protein modifications. Food Chem 141:1227–1241

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

EJC acknowledges longtime support from the US Air Force (AFOSR FA9550-19-1-0413) and ExxonMobil Foundation (S18200000000256). The U.S. Government is authorized to reproduce and distribute for governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the author and should not be interpreted as necessarily representing policies or endorsement, either expressed or implied. Sponsors had no involvement in study design, collection, analysis, interpretation, writing and decision to and where to submit for publication consideration.

Author information

Authors and Affiliations

  1. Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, FL, USA

    A. Wallace Hayes

  2. University of Maine, 5728 Fernald Hall, Room 201, Orono, ME, 04469, USA

    Peter Pressman

  3. Sri Guru Ram Das (SGRD), University of Health Sciences, Amritsar, India

    Gaurav Dhawan

  4. Saint Francis Hospital and Medical Center, Hartford, CT, USA

    Rachna Kapoor

  5. School of Ecology and Applied Meteorology, Nanjing University of Information Science and Technology, Nanjing, 210044, China

    Evgenios Agathokleous

  6. Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via Santa Sofia 97, 95123, Catania, Italy

    Vittorio Calabrese

  7. School of Public Health and Health Sciences, Department of Environmental Health, Morrill I-N344, University of Massachusetts, Amherst, MA, 01003, USA

    Edward J. Calabrese

Authors
  1. Edward J. Calabrese
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Wallace Hayes
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter Pressman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gaurav Dhawan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rachna Kapoor
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Evgenios Agathokleous
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Vittorio Calabrese
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Edward J. Calabrese.

Ethics declarations

Conflict of interest

The authors declare they have no conflict of interest.

Ethical standards

The manuscript does not contain clinical studies or patient data.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Calabrese, E.J., Hayes, A.W., Pressman, P. et al. Flavonoids commonly induce hormetic responses. Arch Toxicol 98, 1237–1240 (2024). https://doi.org/10.1007/s00204-024-03684-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00204-024-03684-8

Keywords

Search

Navigation