Data availability
Data sharing are not available to this article.
References
Bonassi S, Coskun E, Ceppi M, Lando C, Bolognesi C, Burgaz S, Holland N, Kirsh-Volders M, Knasmueller S, Zeiger E, Carnesoltas D, Cavallo D, da Silva J, de Andrade VM, Demircigil GC, Domínguez Odio A, Donmez-Altuntas H, Gattas G, Giri A, Giri S, Gómez-Meda B, Gómez-Arroyo S, Hadjidekova V, Haveric A, Kamboj M, Kurteshi K, Martino-Roth MG, Montero Montoya R, Nersesyan A, Pastor-Benito S, Favero Salvadori DM, Shaposhnikova A, Stopper H, Thomas P, Torres-Bugarín O, Yadav AS, Zúñiga González G, Fenech M (2011) The HUman MicroNucleus project on eXfoLiated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol. Mutat Res 728:88–97
Buczko P, Szarmach I, Grycz M, Kasacka I (2017) Caspase-3 as an important factor in the early cytotoxic effect of nickel on oral mucosa cells in patients treated orthodontically. Folia Histochem Cytobiol 55(1):37–42
Faccioni F, Franceschetti P, Cerpelloni M, Fracasso ME (2003) In vivo study on metal release from fixed orthodontic appliances and DNA damage in oral mucosa cells. Am J Orthod Dentofacial Orthop 124(6):687–693
Natarajan M, Padmanabhan S, Chitharanjan A, Narasimhan M (2011) Evaluation of the genotoxic effects of fixed appliances on oral mucosal cells and the relationship to nickel and chromium concentrations: an in-vivo study. Am J Orthod Dentofacial Orthop 140(3):383–388
Piñeda-Zayas A, Menendez Lopez-Mateos L, Palma-Fernández JC, Iglesias-Linares A (2021) Assessment of metal ion accumulation in oral mucosa cells of patients with fixed orthodontic treatment and cellular DNA damage: a systematic review. Crit Rev Toxicol 51(7):622–633
Funding
DAR thanks CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Grant number #001) for productivity fellowships.
Author information
Authors and Affiliations
Contributions
All authors (WMT, CFAP, and DAR) wrote the letter to the Editor.
Corresponding author
Ethics declarations
Conflict of Interest
All authors declares that no conflict of interest.
Ethics approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Takeshita, W.M., Penteado, C.F.A. & Ribeiro, D.A. Is there a relationship between orthodontic treatment and DNA damage? The relevance of metal ion accumulation in oral mucosa cells. Arch Toxicol 97, 2495–2496 (2023). https://doi.org/10.1007/s00204-023-03496-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00204-023-03496-2