References
Albrecht W, Kappenberg F, Brecklinghaus T et al (2019) Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93(6):1609–1637. https://doi.org/10.1007/s00204-019-02492-9
Chaudhari U, Nemade H, Sureshkumar P et al (2018) Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol 92(1):371–381. https://doi.org/10.1007/s00204-017-2065-z
Colaianna M, Ilmjärv S, Peterson H et al (2016) Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay. Arch Toxicol 91(1):365–391. https://doi.org/10.1007/s00204-016-1690-2
Godoy P, Hewitt NJ, Albrecht U et al (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol 87(8):1315–1530. https://doi.org/10.1007/s00204-013-1078-5
Grandjean P, Landrigan PJ (2014) Neurobehavioural effects of developmental toxicity. Lancet Neurol 13(3):330–338. https://doi.org/10.1016/S1474-4422(13)70278-3
Grinberg M, Stöber RM, Edlund K et al (2014) Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol 88(12):2261–2287. https://doi.org/10.1007/s00204-014-1400-x
Gu X, Albrecht W, Edlund K et al (2018) Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes. Arch Toxicol 92(12):3505–3515. https://doi.org/10.1007/s00204-018-2302-0
Guth S, Hüser S, Roth A et al (2020) Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol 94(5):1375–1415. https://doi.org/10.1007/s00204-020-02725-2
Rempel E, Hoelting L, Waldmann T et al (2015) A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol 89(9):1599–1618. https://doi.org/10.1007/s00204-015-1573-y
Sachinidis A, Albrecht W, Nell P et al (2019) Road map for development of stem cell-based alternative test methods. Trends Mol Med 25(6):470–481. https://doi.org/10.1016/j.molmed.2019.04.003
Shinde V, Perumal Srinivasan S, Henry M et al (2016) Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells. Stem Cell Res Ther 7(1):190. https://doi.org/10.1186/s13287-016-0449-2
Sisnaiske J, Hausherr V, Krug AK et al (2014) Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons. Neurotoxicology 43:117–126. https://doi.org/10.1016/j.neuro.2014.03.010
Nemade H, Chaudhari U, Acharya A et al (2018) Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol 92(4):1507–1524. https://doi.org/10.1007/s00204-018-2170-7
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Seddek, Al., Ghallab, A. Fluoride: no evidence of developmental neurotoxicity due to current exposure levels in Europe. Arch Toxicol 94, 2543–2544 (2020). https://doi.org/10.1007/s00204-020-02823-1
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DOI: https://doi.org/10.1007/s00204-020-02823-1