References
Bersuker K, Hendricks J, Li Z et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. https://doi.org/10.1038/s41586-019-1705-2
Chapa-Dubocq X, Makarov V, Javadov S (2018) Simple kinetic model of mitochondrial swelling in cardiac cells. J Cell Physiol 233(7):5310–5321. https://doi.org/10.1002/jcp.26335
Conrad M, Pratt DA (2019) The chemical basis of ferroptosis. Nat Chem Biol 15(12):1137–1147. https://doi.org/10.1038/s41589-019-0408-1
Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060–1072. https://doi.org/10.1016/j.cell.2012.03.042
Doll S, Freitas FP, Shah R et al (2019) FSP1 is a glutathione-independent ferroptosis suppressor. Nature. https://doi.org/10.1038/s41586-019-1707-0
Feng H, Stockwell BR (2018) Unsolved mysteries: how does lipid peroxidation cause ferroptosis? PLoS Biol 16(5):e2006203. https://doi.org/10.1371/journal.pbio.2006203
Gao M, Yi J, Zhu J et al (2019) Role of mitochondria in ferroptosis. Mol Cell 73(2):354–363. https://doi.org/10.1016/j.molcel.2018.10.042
Gaschler MM, Hu F, Feng H, Linkermann A, Min W, Stockwell BR (2018) Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis. ACS Chem Biol 13(4):1013–1020. https://doi.org/10.1021/acschembio.8b00199
Jaeschke H (2015) Acetaminophen: dose-dependent drug hepatotoxicity and acute liver failure in patients. Dig Dis 33(4):464–471. https://doi.org/10.1159/000374090
Magtanong L, Ko PJ, To M et al (2018) Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem Biol. https://doi.org/10.1016/j.chembiol.2018.11.016
Stockwell BR, Friedmann Angeli JP, Bayir H et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171(2):273–285. https://doi.org/10.1016/j.cell.2017.09.021
Yamada N, Karasawa T, Kimura H et al (2020a) Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. Cell Death Dis. https://doi.org/10.1038/s41419-020-2334-2
Yamada N, Karasawa T, Wakiya T et al (2020b) Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: potential role of ferroptosis. Am J Transpl. https://doi.org/10.1111/ajt.15773
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Yamada, N., Komada, T., Ohno, N. et al. Acetaminophen-induced hepatotoxicity: different mechanisms of acetaminophen-induced ferroptosis and mitochondrial damage. Arch Toxicol 94, 2255–2257 (2020). https://doi.org/10.1007/s00204-020-02722-5
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DOI: https://doi.org/10.1007/s00204-020-02722-5