Fig. 9

Proposed mechanism of IL-6-mediated genotoxicity of BaP and PhIP: IL-6 induces CYP1B1 independently of Aryl hydrocarbon receptor (AhR) via down-regulation of miR27b. BaP also induces expression of IL-6. Induction of CYP1B1 resulted in increased bio-activation of food-derived carcinogens BaP and PhIP, leading to induction of genotoxicity