Abstract
The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in p.Pro206Pro showed significantly higher urinary monomethylarsonic acid (MMAV) and lower dimethylarsinic acid (DMAV)/MMAV ratio than genotype AG. As for p.Arg399Gln, both Arg/Arg homozygous subjects and Arg/Gln heterozygous individuals showed a significantly higher urinary inorganic As percentage and lower 8-OHdG concentrations than Gln/Gln homozygous. Our results suggested that Arg399Gln is a functional SNP that may be related to DNA repair activity.
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This work was supported in part by Grants-in-Aid from the Japan Society for the Promotion of Science (26713025 to JF).
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Fujihara, J., Yasuda, T., Iwata, H. et al. Association of XRCC1 polymorphisms with arsenic methylation. Arch Toxicol 90, 1009–1012 (2016). https://doi.org/10.1007/s00204-015-1490-0
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DOI: https://doi.org/10.1007/s00204-015-1490-0