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Nephrotoxicity of contrast media and protective effects of acetylcysteine

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An Erratum to this article was published on 21 January 2011

Abstract

Contrast-induced acute kidney injury (CI-AKI) accounts for approximately 10% of all causes of hospital-acquired renal failure, causes a prolonged in-hospital stay, and represents a powerful predictor of poor early and late outcome. N-acetylcysteine (NAC) is a thiol compound classically known as a mucolytic agent, which is a potent antioxidant that scavenges a wide variety of oxygen-derived-free-radicals and may be capable of preventing acute kidney injury. In the present study, we will review (1) the pathophysiology of the CI-AKI and (2) the experimental and clinical data on the effects of NAC in preventing CI-AKI.

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Authors and Affiliations

  1. Clinica Mediterranea, Laboratory of Interventional Cardiology, Via Orazio, 2, 80121, Naples, Italy

    Carlo Briguori

  2. Department of Cellular and Molecular Biology and Pathology, and IEOS, CNR, Federico II University of Naples, Via Pansini, 5, 80121, Naples, Italy

    Cristina Quintavalle

  3. IRCCS Multimedica, Milan, Italy

    Francesca De Micco

  4. Fondazione SDN, Via Gianturco 113, 80121, Naples, Italy

    Gerolama Condorelli

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  1. Carlo Briguori
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  2. Cristina Quintavalle
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  3. Francesca De Micco
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  4. Gerolama Condorelli
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Correspondence to Carlo Briguori or Gerolama Condorelli.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00204-011-0647-8

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Briguori, C., Quintavalle, C., De Micco, F. et al. Nephrotoxicity of contrast media and protective effects of acetylcysteine. Arch Toxicol 85, 165–173 (2011). https://doi.org/10.1007/s00204-010-0626-5

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