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A comprehensive review on human disease—causing bacterial proteases and their impeding agents

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Abstract

Proteases are enzymes that catalyze the amide bond dissociation in polypeptide and protein peptide units. They are categorized into seven families and are responsible for a wide spectrum of human ailments, such as various types of cancers, skin infections, urinary tract infections etc. Specifically, the bacterial proteases cause a huge impact in the disease progression. Extracellular bacterial proteases break down the host defense proteins, while intracellular proteases are essential for pathogens virulence. Due to its involvement in disease pathogenesis and virulence, bacterial proteases are considered to be potential drug targets. Several studies have reported potential bacterial protease inhibitors in both Gram-positive and Gram-negative disease causing pathogens. In this study, we have comprehensively reviewed about the various human disease-causing cysteine, metallo, and serine bacterial proteases as well as their potential inhibitors.

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(Source: Veltri 2015)

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Acknowledgements

The authors thank the Computational Biology Lab, Department of Bioinformatics, Bharathiar University for the computational facilities.

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Authors and Affiliations

  1. Department of Biotechnology, PSG College of Technology, Coimbatore, India

    Shobana Sundar

  2. Computational Biology Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, India

    Shanmughavel Piramanayagam

  3. Data Mining and Text Mining Laboratory, Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India

    Jeyakumar Natarajan

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SS conceptualization and writing, SP reviewing and proofing, NJ—reviewing and proofing.

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Sundar, S., Piramanayagam, S. & Natarajan, J. A comprehensive review on human disease—causing bacterial proteases and their impeding agents. Arch Microbiol 205, 276 (2023). https://doi.org/10.1007/s00203-023-03618-5

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