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Association between weight changes and changes in hip geometric indices in the Japanese female population during 10-year follow-up: Japanese Population-based Osteoporosis (JPOS) Cohort Study

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Abstract

Summary

During a 10-year follow-up of 893 women of various ages from the Japanese Population-based Osteoporosis Cohort Study, we evaluated the relationship between weight changes and hip geometric strength assessed by hip structure analysis. Our findings suggest that maintaining weight may help retain geometric strength and reduce hip fracture risk.

Introduction

The effects of changes in anthropometric indices on hip geometry in women of various ages are unclear. We evaluated these effects by analyzing 10-year longitudinal data from a representative sample of Japanese women.

Methods

Dual-energy X-ray absorptiometry scans of the proximal femur were performed at baseline and at the 10-year follow-up. Data were analyzed with the Hip Structure Analysis (HSA) program, which yields geometric strength indices including cross-sectional area (CSA), section modulus (SM) and subperiosteal diameter (PD) at regions of interest (ROIs) in the narrow neck (NN), intertrochanter, and femoral shaft (FS) regions. Annual percent change of each HSA index was determined. Height and weight were measured at baseline and follow-up.

Results

After excluding subjects with factors affecting bone metabolism, we evaluated 893 women (18–79 years old at baseline). The greatest changes in most HSA indices during the follow-up were observed in subjects aged ≥70 years at all ROIs. PD modestly but significantly expanded with age, but this change was not significant in subjects aged ≥70 years or those who had entered menopause ≥20 years before baseline. An increasing trend in weight was associated with an increase or smaller decline in CSA and SM at the NN and FS regions regardless of menopausal status after adjusting for age, height, and weight at baseline and change of estimated volumetric bone mineral density. Changes in height showed a much weaker association with HSA indices.

Conclusions

Maintaining weight may help retain hip geometric strength and reduce the risk of hip fracture.

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Acknowledgments

This study was designed and conducted by the JPOS study group (Chairman, Hideo Yoneshima, MD, PhD, President, Shuwa General Hospital) comprising Fumiaki Marumo (former chairman of the study group, Professor Emeritus, Tokyo Medical and Dental University), Toshihisa Matsuzaki (former co-chairman of the study group, Professor Emeritus, University of the Ryukyus), Takashi Akiba (Tokyo Women’s Medical University), Etsuko Kajita (Nagoya University School of Health Sciences), Harumi Nishino (Toyama Pharmaceutical Association), Tomoharu Matsukura (Toyama Prefectural Government), Toshio Matsumoto (University of Tokushima Graduate School of Medical Sciences), and Takashi Yamagami (Hokuriku Health Service Association), in addition to the authors. Financial support for the baseline survey was provided by the Japan Milk Promotion Board and the Japan Dairy Council. The follow-up surveys were financially supported by Grants-in-Aid for Scientific Research (#18390201, 2006–2007; #20659103, 2008–2009) from the Japanese Society for the Promotion of Science and a Grant-in-Aid for Study on Milk Nutrition (2006) from the Japan Dairy Association. The authors wish to thank Toyo Medic Co., Osaka, Japan and Toyukai Medical Corporation, Tokyo, Japan, for their technical assistance and personnel at the health departments of Miyakojima City, Sanuki City, and Nishi-aizu Town for their excellent support.

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    N. DongMei, M. Iki & J. Tamaki

  2. Department of Human Life, Jin-ai University, 3-1-1 Otemachi, Echizen, Fukui, 915-8586, Japan

    Y. Sato

  3. University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan

    S. Kagamimori

  4. Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama, 350-0288, Japan

    Y. Kagawa

  5. Shuwa General Hospital, 1200 Tanihara-shinden, Kasukabe, Saitama, 344-0035, Japan

    H. Yoneshima

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  1. N. DongMei
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  2. M. Iki
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  3. J. Tamaki
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  4. Y. Sato
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  5. S. Kagamimori
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  6. Y. Kagawa
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  7. H. Yoneshima
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Japanese Population-based Osteoporosis (JPOS) Study Group

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Correspondence to M. Iki.

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DongMei, N., Iki, M., Tamaki, J. et al. Association between weight changes and changes in hip geometric indices in the Japanese female population during 10-year follow-up: Japanese Population-based Osteoporosis (JPOS) Cohort Study. Osteoporos Int 23, 1581–1591 (2012). https://doi.org/10.1007/s00198-011-1733-8

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  • DOI: https://doi.org/10.1007/s00198-011-1733-8

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