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Relationship between mandibular inferior cortex and general bone metabolism in older adults

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Abstract

Summary

The purpose of this study was to investigate whether a link exists between the jawbone and general bone metabolism. The results of our study indicate that a mandibular inferior cortical erosion finding on dental panoramic radiographs is significantly associated with increased biochemical markers of bone turnover.

Introduction

The purpose of this study was to investigate whether a link exists between the jawbone and general bone metabolism.

Methods

We measured values of serum bone-specific alkaline phosphatase (S-BAP) and urinary N-telopeptide cross-links of type I collagen (U-NTX). To evaluate the jawbone, we used mandibular inferior cortex (MIC) classification on dental panoramic radiographs. After 134 subjects were divided into three groups (C1: normal cortex, C2: mildly to moderately eroded cortex, C3: severely eroded cortex), we evaluated the relationship between S-BAP or U-NTX and MIC classification by Scheffe’s multiple comparison test.

Results

A significant correlation was found between MIC classification and S-BAP (C1 vs. C2: p < 0.01, C1 vs. C3: p < 0.01, C2 vs. C3: NS). A significant correlation was found between MIC classification and U-NTX (C1 vs. C2: p < 0.01, C1 vs. C3: p < 0.001, C2 vs. C3: p < 0.01).

Conclusions

The results of our study indicate that the mandibular inferior cortical erosion finding on dental panoramic radiographs is significantly associated with increased S-BAP and U-NTX levels. We suggest that there is an association between the jawbone and general bone metabolism.

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Acknowledgments

This work was supported by Grant-in-Aids from Japan Society for the Promotion of Science (No.17592177) and from the Ministry of Health and Welfare of Japan (H16-Iryo-001). We are grateful to Dr Taguchi (Hiroshima University) for technical assistance.

Conflicts of interest

None.

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Authors and Affiliations

  1. Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, 2-5274, Gakkocho-Dori, Chuo-Ku, Niigata, 951-8514, Japan

    T. Deguchi, A. Yoshihara & H. Miyazaki

  2. Department of Oral Health Science, National Institute of Public Health, 2-3-6, Minami, Wako, 351-0197, Japan

    N. Hanada

Authors
  1. T. Deguchi
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  2. A. Yoshihara
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  3. N. Hanada
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  4. H. Miyazaki
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Correspondence to T. Deguchi.

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Deguchi, T., Yoshihara, A., Hanada, N. et al. Relationship between mandibular inferior cortex and general bone metabolism in older adults. Osteoporos Int 19, 935–940 (2008). https://doi.org/10.1007/s00198-007-0526-6

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  • DOI: https://doi.org/10.1007/s00198-007-0526-6

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