Abstract
To gain insight into the growth- and age-related origins of bone fragility at the proximal femur, we analyzed structural and biomechanical data of the femoral neck from a study of postmenopausal women with hip fractures and their 47 premenopausal daughters. Results were expressed as standard deviations (SD) or Z-scores (mean ± SEM) adjusted for age and weight, derived using a normal reference population of 262 premenopausal women and 370 postmenopausal women. Women with hip fractures had increased femoral neck (FN) periosteal and endocortical diameters (1.01 ± 0.26 SD and 1.18 ± 0.25 SD, respectively). Cortical thickness was reduced by 0.96 ± 0.1 SD and volumetric bone mineral density (vBMD) was reduced by 1.2 ± 0.1 SD). The section modulus was normal while the buckling ratio was increased by 1.59 ± 0.17 SD). Their daughters had increased FN diameter by about one half that of their mothers (0.48 ± 0.16 SD), while endocortical diameter was increased by only one third (0.44 ± 0.13 SD). Cortical thickness and vBMD were not reduced, the section modulus was increased (0.48 ± 0.13 SD) while the buckling ratio was normal. We infer that the larger femoral neck size in women with hip fractures is growth-related; the wider endocortical cavity and thinner cortex is the result of excessive age-related endocortical bone resorption producing a thin cortex in a larger bone predisposing to structural failure by local buckling. The structural basis of bone fragility has some features originating during growth and others during aging.
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Acknowledgements
We thank senior technologists, Alison Evans and Patricia D’Souza, for their technical assistance. This work was supported by a grant from the Australia National Health and Medical Research Council (G145820).
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Filardi, S., Zebaze, R.M.D., Duan, Y. et al. Femoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during aging. Osteoporos Int 15, 103–107 (2004). https://doi.org/10.1007/s00198-003-1539-4
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DOI: https://doi.org/10.1007/s00198-003-1539-4