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Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse

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Abstract

Introduction and hypothesis

Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism −1997 G/T with genital prolapse in Brazilian women.

Methods

A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the −1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein’s coding sequence.

Results

No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or ≥ 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse.

Conclusions

Our study could not find any association between the −1997G/T polymorphism and genital prolapse in Brazilian women.

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Acknowledgments

The authors thank the FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) for financially supporting this research under contract 2014/01107-6.

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Authors and Affiliations

  1. Department of Urogynecology and Vaginal Surgery within the Discipline of Gynecology at the ABC Medical School, Santo André, SP, Brazil

    Claudia Cristina Palos, Denise de Souza Paulo, Cesar Eduardo Fernandes & Emerson Oliveira

  2. São Paulo, Brazil

    Claudia Cristina Palos

  3. Department of Morphology and Physiology at the ABC Medical School, Santo André, SP, Brazil

    Beatriz Ferreira Timm & Ricardo Peres de Souto

Authors
  1. Claudia Cristina Palos
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  2. Beatriz Ferreira Timm
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  3. Denise de Souza Paulo
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  4. Cesar Eduardo Fernandes
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  5. Ricardo Peres de Souto
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  6. Emerson Oliveira
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Synopsis

In this cohort study, original in the literature, we could not identify any association between collagenous −1997G/T polymorphism and pelvic organ prolapse in Brazilian women.

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Palos, C.C., Timm, B.F., de Souza Paulo, D. et al. Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse. Int Urogynecol J 31, 133–137 (2020). https://doi.org/10.1007/s00192-018-3833-x

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  • DOI: https://doi.org/10.1007/s00192-018-3833-x

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