References
Dietz HP (2012) Genetics of pelvic organ prolapse: comment. Int Urogynecol J Pelvic Floor Dysfunct. doi:10.1007/s00192-011-1638-2
Bortolini MA, Rizk DEE (2011) Genetics of pelvic organ prolapse: crossing the bridge between bench and bedside in urogynecologic research. Int Urogynecol J Pelvic Floor Dysfunct 22:1211–1219. doi:10.1007/s00192-011-1502-4
Bortolini MA, Drutz HP, Lovatsis D, Alarab M (2010) Vaginal delivery and pelvic floor dysfunction: current evidence and implications for future research. Int Urogynecol J Pelvic Floor Dysfunct 21(8):1025–1030
Hansell NK, Dietz HP, Treloar SA, Clarke B, Martin NG (2004) Genetic covariation of pelvic organ and elbow mobility in twins and their sisters. Twin Res 7(3):254–260
Jack GS, Nikolova G, Vilain E, Raz S, Rodríguez LV (2006) Familial transmission of genitovaginal prolapse. Int Urogynecol J Pelvic Floor Dysfunct 17(5):498–501
Nikolova G, Lee H, Berkovitz S et al (2007) Sequence variation in laminin gamma 1 (LAMC1) gene associated with familial pelvic organ prolapse. Human Genet 120:847–856
Altman D, Forsman M, Falconer C, Lichtenstein P (2008) Genetic influence on stress urinary incontinence and pelvic organ prolapse. Eur Urol 54(4):918–922
Allen-Brady K, Norton PA, Farnham JM, Teerlink C, Cannon-Albright LA (2009) Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21. Am J Hum Genet 84:678–682
Miedel A, Tegerstedt G, Maehle-SchmidtM NO, Hammarström M (2009) Nonobstetric risk factors for symptomatic pelvic organ prolapse. Obstet Gynecol 113(5):1089–1097
Campeau L, Gorbachinskt BGH, Andersson KE (2011) Pelvic floor disorders: linking genetic risk factors to biochemical changes. BJU Int 198:1240–1247
Allen-Brady K, Cannon-Albright L, Farham JM, Teerlink C, Vierhout ME, Van Kempen LCL, Kluivers KB, Norton PA (2011) Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis. Obstet Gynecol 118(6):1345–1353
Liu X, Zhao Y, Pawlyk B, Damaser M, Li T (2006) Failure of elastic fiber homeostasis leads to pelvic floor disorders. Am J Pathol 168(2):519–528
Drewes PG, Yanagisawa H, Starcher B et al (2007) Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina. Am J Pathol 170(2):578–589
Abramowitch SD, Feola A, Jallah Z, Moalli PA (2009) Tissue mechanics, animal models, and pelvic organ prolapse: a review. Eur J Obstet Gynecol Reprod Biol 144(Suppl 1):S146–S158
Kerkhof MH, Hendriks L, Brölmann HA (2009) Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature. Int Urogynecol J Pelvic Floor Dysfunct 20(4):461–474
Word RA, Pathi S, Schaffer JI (2009) Pathophysiology of pelvic organ prolapse. Obstet Gynecol Clin North Am 36(3):521–539
Alarab M, Bortolini MA, Drutz H, Lye S, Shynlova O (2010) LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct 21(11):1397–1404
Chen B, Yeh J (2011) Alterations in connective tissue metabolism in stress incontinence and prolapse. J Urol 186(5):1768–1772
Weber AM, Buchsbaum GM, Chen B et al (2004) Basic science and translational research in female pelvic floor disorders: proceedings of an NIH-sponsored meeting. Neurourol Urodyn 23:288–301
Hong KW, Oh B (2010) Overview of personalized medicine in the disease genomic era. BMP reports 43(10):643-648cp
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bortolini, M.A., Rizk, D. Genetics of pelvic organ prolapse: reply. Int Urogynecol J 23, 511–512 (2012). https://doi.org/10.1007/s00192-011-1637-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00192-011-1637-3