Tourniquet use in total knee arthroplasty: a meta-analysis

Abstract

Purpose

The use of an intraoperative tourniquet for total knee arthroplasty (TKA) is a common practice. However, the effectiveness and safety are still questionable. A systematic review was conducted to examine that whether using a tourniquet in TKA was effective without increasing the risk of complications.

Methods

A comprehensive literature search was done in PubMed Medicine, Embase, and other internet database. The review work and the following meta-analysis were processed to evaluate the role of tourniquet in TKA.

Results

Eight randomized controlled trials and three high-quality prospective studies involving 634 knees and comparing TKA with and without the use of a tourniquet were included in this analysis. The results demonstrated that using a tourniquet could decrease the measured blood loss but could not decrease the calculated blood loss, which indicated actual blood loss. Patients managed with a tourniquet might have higher risks of thromboembolic complications. Using the tourniquet with late release after wound closure could shorten the operation time; whereas early release did not show this benefit.

Conclusions

The current evidence suggested that using tourniquet in TKA may save time but may not reduce the blood loss. Due to the higher risks of thromboembolic complications, we should use a tourniquet in TKA with caution.

Introduction

Total knee arthroplasty (TKA) is associated with significant blood loss, for which blood transfusion might be necessary. The role of the tourniquet is controversial, though it is widely used by orthopedic surgeons. Its use was believed to be effective in decreasing intraoperative blood loss and creating a bloodless surgical field, which theoretically would facilitate the cementing technique and other surgical procedures. However, reactive blood flow reached its peak within 5 min after the tourniquet had been released [16]. The tourniquet controls intraoperative blood loss, but cannot stop postoperative blood loss. The role of the tourniquet in the total blood loss of patients undergoing TKA is still questionable.

In addition, the benefits of the tourniquet must be balanced against the shortages and risks. Patients who were managed with a tourniquet during the operation often complained of thigh pain. This was possibly caused by the direct pressure of an inflated tourniquet on the nerves and local soft tissues. Limb swelling and increased soft tissue tension caused by reactive hyperperfusion after tourniquet deflation may also contribute to the wound pain.

Thromboembolism is one of the most serious postoperative complications in orthopedic surgery. Clinically, the use of the pneumatic tourniquet is considered to be one of the most important risk factors for symptomatic thromboembolism [13, 37]. The incidence of deep vein thrombosis (DVT) after TKA performed with a tourniquet was reported to be up to 72–84% in earlier studies [20, 31], but this has been reduced with the advances in thromboembolic prophylaxis. The deflation of a tourniquet also changes the hemodynamic status [26] and allows a substantial amount of emboli to travel from the lower limb into the right atrium, right ventricle, and pulmonary artery [3]. This phenomenon may be predictive of further clinical pulmonary embolic events.

Other tourniquet-related complications have been reported in the literature and include nerve palsy [10], vascular injuries [15], rhabdomyolysis [24], and subcutaneous thigh fat necrosis [32]. The application of a tourniquet also tethers the quadriceps mechanism and thus alters the intraoperative patellofemoral tracking [11, 14, 19]. This change may affect the surgeon’s judgment on soft tissue balancing and the decision to perform lateral release.

Several randomized controlled trials regarding the use of tourniquets have been published, but no consensus has been reached. Heterogeneous data had been reported in these trials. Thus, a meta-analysis was conducted to assess the effects of using a tourniquet for primary TKA, with the aim of quantifying the effect of the tourniquet on reducing blood loss and assessing the possible risks associated with tourniquets.

Methods

We followed the methodological guidelines outlined by the Cochrane Collaboration (Oxford, United Kingdom) [9] in conducting this meta-analysis. The findings were reported according to the recommendations outlined in the Quality of Reporting of Meta-Analyses (QUOROM) statement [21].

Literature search

Two of the authors completed a search of the electronic databases, including the Cochrane Central Register of Controlled Trials (2009), PubMed Medline (1966–2009), and Embase (1980–2009). We used the following search terms and Boolean operators: “tourniquet” AND (“knee arthroplasty” OR “knee replacement”). Editorials and commentaries from major orthopedic journals were also considered for further information on trials of interest. We also used the internet search engine “Google”, searching under the keyword “tourniquet” combined with “knee,” “arthroplasty,” “joint replacement,” “blood loss,” “deep vein thrombosis,” or “pulmonary embolism.” The reference lists of the relevant articles were also looked through for any further relevant studies.

Article selection and validity assessment

We included prospective trials comparing patients undergoing TKA with a tourniquet or not. Retrospective studies or case series were excluded. The blood loss and incidence of thromboembolic events were considered as primary outcomes. After reviewing the titles and abstracts of the studies, we determined whether the study was appropriate for retrieval. We then appraised the studies and identified those eligible for inclusion in our analysis. Using the Consolidated Standards of Reporting Trials (CONSORT) checklist of 22 items [22], we assessed the quality of reporting in each article. All disagreements were resolved by consensus.

Data extraction

Two authors independently extracted the data from the articles. Whenever necessary, we contacted the authors of the studies for the missing data or further information. Encountering any disagreement, we reached a consensus by discussion within the review team. The following data were extracted: (1) participant demographics; (2) indication for TKA; (3) operative methods and usage of the tourniquet; (4) blood loss measures, including the intraoperative blood loss, amount of drainage, total measured blood loss, and calculated blood loss; (5) operation time; (6) thromboembolic events and other tourniquet-related complications. We also contacted the authors for missing data.

Statistical analysis

The outcomes were collected using variance-weighted means. We tested for the presence of heterogeneity with the use of a standard chi-square test (with a level of significance of P = 0.1) and the I 2 statistic [8]. An I 2 statistic value of >50% was considered to indicate substantial heterogeneity. Random-effects analysis [4] was used for comparing trials showing heterogeneity while fixed-effects analysis [17] was used for comparing trials without showing heterogeneity. We calculated the mean difference or relative risk for all outcomes. The meta-analysis was carried out using the RevMan 5 software package (Cochrane Collaboration, Oxford, United Kingdom).

Results

Identified trials

A total of 810 articles were retrieved in the search. Eight randomized controlled trials and three high-quality prospective studies (evidence-based level II) comparing TKA with and without the use of a tourniquet were identified and included in the meta-analysis (Table 1). These studies involved a total of 634 TKAs. The characteristics of operation methods were summarized in Table 2. They included some co-factors that might influence the blood loss in TKA.

Table 1 Characteristics of the studies
Table 2 Characteristics of operation methods

Methodology

The methodological quality of the included studies is summarized in Table 1. The inclusion criteria were reported in all studies, but the exclusion criteria were made known in only four studies. No study reported the method of random sequence generation and the detailed implementation of randomization. Baseline characteristics were not reported in one study [37], which could potentially bias the results and limit the generalizability of the findings.

Outcome analysis

Intraoperative blood loss and postoperative blood drainage were reported in five studies. The pooling data showed that using a tourniquet significantly decreased the blood loss during the operation but slightly increased the postoperative blood loss (Fig. 1c, d). In terms of total measured blood loss (the sum of intraoperative and postoperative blood loss), the pooling data of the five studies favored using a tourniquet (Fig. 1a). However, after taking out an extreme data [7], the pooling result of the remaining studies showed no significant difference between these two groups.

Fig. 1
figure1

a Total measured blood loss: The pooling data of the five studies favored using a tourniquet. However, Harvey et al. [7] had an extreme result. The total measured blood loss in the non-tourniquet group was twice that in the tourniquet group (1,493 versus 709 ml) probably because of cementless technique and prolonged surgical time. After taking out this result, the pooling data of the remaining studies showed no significant difference. b Calculated blood loss: The pooling results revealed slightly less calculated blood loss in the non-tourniquet group. c Intraoperative blood loss: All of five studies showed that using a tourniquet significantly decreased blood loss during the operation. The mean intraoperative blood loss in operations without a tourniquet ranged from 295 to 631 ml. d Postoperative blood loss: The pooling data revealed a slight decrease in the drained volume of the non-tourniquet group. The means of the total drained blood ranged from 290 to 528.5 ml in the tourniquet group and 145 to 661.6 ml in the non-tourniquet group. Overall, pooling date showed that using a tourniquet in TKA could reduce the intraoperative blood loss and total measured blood loss, but could not decrease the calculated blood loss

Three studies mentioned calculated blood loss, which involved taking the patients’ blood volume and change in hematocrit levels into consideration, and was thought to be an exact representation of the true blood loss. The pooling results surprisingly revealed slightly less calculated blood loss in the non-tourniquet group (Fig. 1b).

With respect to thromboembolic events after surgery, eight studies provided data on the incidence of sonographic or clinical DVT and pulmonary embolism. The pooling results found that the risk of clinical thromboembolic events was significantly higher in the tourniquet group than in the non-tourniquet group (Fig. 2a). Symptomatic thromboembolic events occurred in 13.0 and 6.1% of patients in the tourniquet and non-tourniquet group, respectively (Table 3). In the subgroup analysis, both symptomatic DVT and pulmonary embolism occurred more often in the tourniquet group than in the non-tourniquet group, although there was no statistical difference (Fig. 2b, c). One study [36] claimed there were no DVTs in either group. Two studies investigated the incidence of DVT using sonographic image examinations [5, 36]. The diversity of results indicated that the sonographic examination was operator dependent. The pooled results showed no difference between the tourniquet and non-tourniquet groups (Fig. 2d).

Fig. 2
figure2

Results of the meta-analysis of overall clinical thromboembolic events (a) showed the risk of overall thromboembolic complications was increased by using the tourniquet, although there was no significant difference in the subgroup analysis of clinical pulmonary embolism (b) and clinical deep vein thrombosis (c). The two studies of sonographic deep vein thrombosis (d) showed different results of incidence. Fukuda et al. showed a high incidence in both groups (77.8% (21/27) in the tourniquet group and 85.7% (18/21) in the non-tourniquet group, respectively), whereas the other study reported a low incidence (1/37 in the tourniquet group and 0/40 in the non-tourniquet group, respectively)

Table 3 Risk ratio of thromboembolic events

Transesophageal echocardiography was used to detect intraoperative emboli in two studies [12, 37], and both of them reported that snowstorm-like echogenic particles were observed after deflation of the tourniquet in all patients. In the non-tourniquet group, various incidences of embolism were reported during different steps of the operation.

Three studies [1, 33, 36] reported wound problems, including significant hematoma, wound oozing, skin blistering, bruising, superficial wound infection requiring antibiotics treatment, and skin necrosis. The tourniquet group was found to have a higher incidence of postoperative wound problems than the non-tourniquet group (risk ratio: 3.04, P = 0.008, 95%CI: 1.33–6.95).

Eight studies reported a comparison of operation times between the two groups [2, 5, 12, 18, 23, 33, 35, 37]. Subgroup analysis was done according to the timing of releasing tourniquet. Using the tourniquet with early release (deflation after cementing for hemostasis) did not shorten the operation time. However, late release of tourniquet (deflation after wound closure and dressing) would shorten the operation time compared with non-tourniquet groups (Fig. 3). The overall pooling results also found significant shorter operation time in tourniquet group.

Fig. 3
figure3

Results of meta-analysis of operation time and the following subgroup analysis. Three studies with early release of tourniquet showed no difference between tourniquet and non-tourniquet groups. Five studies with late release of tourniquet showed shorter operation time in tourniquet group

Discussion

The most important finding of the present meta-analysis was that the true blood loss in TKA was not reduced using a tourniquet, although intraoperative blood loss was significantly less in tourniquet group. In addition, more thromboembolic events and wound complications were identified in the tourniquet group. The effectiveness and safety profile of the tourniquet are questionable.

The pooling data showed that the patients with whom a tourniquet was used in TKA had less total measured operative blood loss. However, we now know that the total measured blood loss represents only a fraction of the true blood loss. The new concept of “calculated blood loss” was introduced using Gross’ method [6]. Various studies have indicated that this method likely provides a much more accurate estimation of the true blood loss, than measured blood loss [27, 30]. The pooling results in the meta-analysis found no significant difference between the two groups. Two current studies even showed that using a tourniquet caused more calculated blood loss [18, 33]. Therefore, we concluded that using a tourniquet does not reduce the overall blood loss effectively.

The results of this analysis also confirmed that there is often a substantial hidden or unmeasured blood loss in TKA [28]. The intraoperative and total measured blood loss were significantly less in the tourniquet group than in the non-tourniquet group, but the pooling results of calculated blood loss showed no significant difference. This phenomenon suggests that TKA involves some blood loss that is not recognized in the routine assessment of either intraoperative blood loss or the postoperative drainage amount, especially when using a tourniquet during the operation [18]. Surgeons tended to underestimate the surgical blood loss in this situation. In fact, reactive blood flow increases with the peak flow appearing within 5 min after the tourniquet is released [16]. This finding supports the notion that patients with whom a tourniquet is used might have more hidden blood loss after the operation.

Thromboembolism is one of the most common complications after TKA and is of great concern because of the associated increases in morbidity and mortality reported in the literature. In the meta-analysis, we found the incidence of clinical thromboembolic events was higher in patients managed with a tourniquet than in those without it. The critical point is the deflation of the tourniquet right after the operation. Transesophageal echocardiography demonstrated shower-like echogenic materials circulating from the lower limbs to the right atrium, ventricle, and pulmonary artery after release of the tourniquet [12, 37]. This phenomenon lasted for several minutes. The histological examination of these materials showed only thrombi, and no fat, bone marrow, or bone cement [3]. Fortunately, the sonographic phenomenon of embolism was not always clinically relevant. Although the transesophageal echocardiography was thought to be over sensitive, these results hinted us that the thromboembolism was an important issue requiring careful management. To date, no approach to venous thromboembolic prophylaxis has been universally accepted by orthopedic surgeons. The methods of prophylaxis varied among the included studies. Our results suggested that this issue should be of great concern in TKA performed with tourniquet inflation.

The circulatory stasis caused by tourniquet inflation worsened the local soft tissue condition and might have impaired wound healing. Fortunately, most of the complications were mild. Other confounding factors also influenced the soft tissue condition and wound healing. Further studies are needed to investigate the effect of the tourniquet on wound healing.

Regarding the operation time, we should take the timing of tourniquet deflation into account. The tourniquet was released after wound closure and compressive dressing in five studies [12, 18, 23, 35, 37]. The pooling result of the operation time among them showed significantly shorter in the tourniquet group. Three studies with early release of tourniquet did not report this benefit [2, 5, 33]. This finding was consistent with our experience and the recent trials [34]. Releasing the tourniquet right after cementing the prosthesis for hemostasis would cause longer operation time than releasing it after wound closure. However, the influence of the timing of release on blood loss is still controversial [25, 29].

The bias of these studies might come from the measurement of intraoperative blood loss. Most of surgeon counted intraoperative blood loss according to the amount of blood in suction bags. This method might underestimate the blood loss when the tourniquet was not used. Several included articles mentioned how they accurately measured the intraoperative blood loss [2, 7, 18, 33]. Most of them counted the suction amount and weighed sponges or gauzes in the operative room. The other perioperative management may also impact on blood loss. Some examples are number of drains, timing of removal of drains, temporary clamping of drains or not, and type of postoperative compressive dressing (Table 2). No author temporarily clamped the drain after the operations in our included studies. We did not found the methods of drainage and dressing as confounding factors in our results.

We evaluated the quality of the included studies using the CONSORT statement, which included 22 items for the analysis of randomized controlled trials. The lack of any of the items is associated with biased estimates of the treatment effect, because the information is essential to judge the reliability or relevance of the findings [22]. Our assessment revealed that the weakness of the included randomized studies was mainly the poor methods or description of randomization. Two of the three prospective non-randomized studies allocated the consecutive patients into tourniquet or non-tourniquet groups based on the date of operation to minimize the bias [5, 23]. The other study was part of a double-blind thromboprophylaxis trial [7]; no clear statement of criteria for patient selection was reported.

The major limitation of this analysis is the small sample size. We could not perform statistical tests to eliminate the publication bias. However, such bias was minimized by our comprehensive search, duplicate selection process, and evaluation of methodology. One article reported the operation time as mean and ranges rather than standard deviations [35]. We treated the results as normally distributed data, so the standard deviations were estimated to be one-quarter of the ranges of the data values [9]. This estimation might generate bias. However, excluding this study did not change the conclusion of the pooled results.

Although some reports opposing the use of the tourniquet in TKA have been published, the issue remains controversial and the technique is still widely used by surgeons when performing TKA. We suggested that the tourniquet should not be used in patients with high risks of thromboembolism. The thromboprophylaxis and closely monitoring the patients postoperatively are mandatory if the tourniquet was using in TKA. In addition, the hidden blood loss should be kept in mind due to the reactive blood flow after deflation of the tourniquet. The postoperative hemoglobin and hematocrit levels should always be checked to evaluate the blood loss and the need for blood transfusion.

Conclusion

This meta-analysis provided the best evidence regarding the application of the tourniquet in TKA to date because the sample size was far more than those in each single study. The available evidence indicated that although using the tourniquet provided good visualization of the surgical field, it could not reduce the actual blood loss. It saved the operation time only when it was released after wound closure and dressing. The tourniquet might be associated with an increased incidence of thromboembolic events and wound complications. When using the tourniquet in TKA, the surgeons should carefully consider its effectiveness and safety. Inflating the tourniquet only while cementing or for limited time might be an option. Additional well-designed randomized controlled trials are required to clarify the roles of tourniquet and compare the effects of different methods of tourniquet applications in TKA.

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Tai, TW., Lin, CJ., Jou, IM. et al. Tourniquet use in total knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthrosc 19, 1121–1130 (2011). https://doi.org/10.1007/s00167-010-1342-7

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Keywords

  • Tourniquet
  • Knee arthroplasty
  • Blood loss
  • Thromboembolism
  • Meta-analysis