Skip to main content
SpringerLink
Log in

Four-factor prothrombin complex concentrate in trauma patients

  • What's New in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Puchstein D, Kork F, Schochl H, Rayatdoost F, Grottke O (2023) 3-Factor versus 4-Factor prothrombin complex concentrates for the reversal of Vitamin K antagonist-associated coagulopathy: a systematic review and Meta-analysis. Thromb Haemost 123:40–53

    Article  PubMed  PubMed Central  Google Scholar 

  2. Rossaint R, Afshari A, Bouillon B, Cerny V, Cimpoesu D, Curry N, Duranteau J, Filipescu D, Grottke O, Gronlykke L, Harrois A, Hunt BJ, Kaserer A, Komadina R, Madsen MH, Maegele M, Mora L, Riddez L, Romero CS, Samama CM, Vincent JL, Wiberg S, Spahn DR (2023) The European guideline on management of major bleeding and coagulopathy following trauma sixth edition. Crit Care 27:80

    Article  PubMed  PubMed Central  Google Scholar 

  3. Schochl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C (2010) Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 14:R55

    Article  PubMed  PubMed Central  Google Scholar 

  4. Schochl H, Nienaber U, Maegele M, Hochleitner G, Primavesi F, Steitz B, Arndt C, Hanke A, Voelckel W, Solomon C (2011) Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care 15:R83

    Article  PubMed  PubMed Central  Google Scholar 

  5. Nienaber U, Innerhofer P, Westermann I, Schochl H, Attal R, Breitkopf R, Maegele M (2011) The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion. Injury 42:697–701

    Article  PubMed  Google Scholar 

  6. Innerhofer P, Fries D, Mittermayr M, Innerhofer N, von Langen D, Hell T, Gruber G, Schmid S, Friesenecker B, Lorenz IH, Strohle M, Rastner V, Trubsbach S, Raab H, Treml B, Wally D, Treichl B, Mayr A, Kranewitter C, Oswald E (2017) Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial. Lancet Haematol 4:e258–e271

    Article  PubMed  Google Scholar 

  7. Jehan F, Aziz H, O’Keeffe T, Khan M, Zakaria ER, Hamidi M, Zeeshan M, Kulvatunyou N, Joseph B (2018) The role of four-factor prothrombin complex concentrate in coagulopathy of trauma: a propensity matched analysis. J Trauma Acute Care Surg 85:18–24

    Article  CAS  PubMed  Google Scholar 

  8. Zeeshan M, Hamidi M, Feinstein AJ, Gries L, Jehan F, Sakran J, Northcutt A, O’Keeffe T, Kulvatunyou N, Joseph B (2019) Four-factor prothrombin complex concentrate is associated with improved survival in trauma-related hemorrhage: a nationwide propensity-matched analysis. J Trauma Acute Care Surg 87:274–281

    Article  CAS  PubMed  Google Scholar 

  9. Joseph B, Aziz H, Pandit V, Hays D, Kulvatunyou N, Yousuf Z, Tang A, O’Keeffe T, Green D, Friese RS, Rhee P (2014) Prothrombin complex concentrate versus fresh-frozen plasma for reversal of coagulopathy of trauma: is there a difference? World J Surg 38:1875–1881

    Article  PubMed  Google Scholar 

  10. Joseph B, Khalil M, Harrison C, Swartz T, Kulvatunyou N, Haider AA, Jokar TO, Burk D, Mahmoud A, Latifi R, Rhee P (2016) Assessing the efficacy of prothrombin complex concentrate in multiply injured patients with high-energy pelvic and extremity fractures. J Orthop Trauma 30:653–658

    Article  PubMed  Google Scholar 

  11. Bouzat P, Charbit J, Abback PS, Huet-Garrigue D, Delhaye N, Leone M, Marcotte G, David JS, Levrat A, Asehnoune K, Pottecher J, Duranteau J, Courvalin E, Adolle A, Sourd D, Bosson JL, Riou B, Gauss T, Payen JF, Group PS (2023) Efficacy and Safety of Early Administration of 4-factor prothrombin complex concentrate in patients with trauma at risk of massive transfusion: the PROCOAG randomized clinical trial. JAMA 329:1367–1375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Muller MC, Straat M, Meijers JC, Klinkspoor JH, de Jonge E, Arbous MS, Schultz MJ, Vroom MB, Juffermans NP (2015) Fresh frozen plasma transfusion fails to influence the hemostatic balance in critically ill patients with a coagulopathy. J Thromb Haemost 13:989–997

    Article  CAS  PubMed  Google Scholar 

  13. Dunbar NM, Chandler WL (2009) Thrombin generation in trauma patients. Transfusion 49:2652–2660

    Article  CAS  PubMed  Google Scholar 

  14. Baksaas-Aasen K, Van Dieren S, Balvers K, Juffermans NP, Naess PA, Rourke C, Eaglestone S, Ostrowski SR, Stensballe J, Stanworth S, Maegele M, Goslings JC, Johansson PI, Brohi K, Gaarder C, collaborators TI (2019) Data-driven development of ROTEM and TEG algorithms for the management of trauma hemorrhage: a prospective observational multicenter study. Ann Surg 270:1178–1185

    Article  PubMed  Google Scholar 

  15. Dujardin RWG, Kleinveld DJB, Gaarder C, Brohi K, Davenport RA, Curry N, Stanworth S, Johansson PI, Stensballe J, Maegele M, Juffermans NP (2022) coagulopathy underlying rotational thromboelastometry derangements in trauma patients: a prospective observational multicenter study. Anesthesiology 137:232–242

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. CHU Grenoble Alpes, Grenoble Institute Neurosciences, Université Grenoble Alpes, Inserm, U1216, 38000, Grenoble, France

    Pierre Bouzat

  2. Thrombosis and Haemophilia Centre, Guy’s and St Thomas’ NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK

    Beverley J. Hunt

  3. Department Intensive Care and Laboratory of Translational Intensive Care, Erasmus Medical Center, Rotterdam, The Netherlands

    Nicole P. Juffermans

  4. Pôle d’Anesthésie-Réanimation, Hôpital Albert Michallon, BP 217, 38043, Grenoble, France

    Pierre Bouzat

Authors
  1. Pierre Bouzat
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Beverley J. Hunt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nicole P. Juffermans
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pierre Bouzat.

Ethics declarations

Conflicts of interest

PB reports receiving payment for lecture by LFB (Les Ullis, France), BJH and NPJ report no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bouzat, P., Hunt, B.J. & Juffermans, N.P. Four-factor prothrombin complex concentrate in trauma patients. Intensive Care Med 49, 1242–1244 (2023). https://doi.org/10.1007/s00134-023-07170-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-023-07170-0

Search

Navigation