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Initial correspondence from Drs. Santini, Votta and Protti
Dear Editor,
Driving airway pressure (ΔP) is the increase in airway pressure due to tidal volume inflation during mechanical ventilation. It is measured as the difference between end-inspiratory pause (plateau, P plat) and end-expiratory (PEEP) airway pressure.
There is no consensus on how to measure P plat. Mezidi and colleagues [1] highlighted how P plat, and thus ΔP, depends on the duration of end-inspiratory pause. To obtain appropriate (i.e. truly static) measures, pauses as long as 2 s, compared to 0.5 s, are required. However, mechanical ventilation is a dynamic process that usually does not comprise such prolonged pauses.
As long as ΔP is defined as P plat—PEEP, the longer the pause, the more reliable the measurement [1]. But if ΔP is meant to reflect the maximal increase in alveolar pressure during ongoing ventilation, then a prolonged pause will probably underestimate it. In fact, after an end-inspiratory pause, airway pressure initially drops to P1 while airflow drops to zero. Thereafter, it further declines to P plat (Fig. 1) mainly because of gas redistribution and lung tissue stress relaxation [2, 3]. P1, but not P plat, includes this latter airway pressure gradient that “artificially” dissipates during prolonged end-inspiratory pauses.
We thus wonder whether P1 should replace P plat to better estimate the effective (i.e. dynamic) driving airway pressure during cyclic tidal inflation. If that is the case, then even end-inspiratory pauses as short as 0.5 s will be too long. Of note, P1 could be readily measured by modern ventilators, as the airway pressure when airflow becomes zero.
Reply from Drs. Mezidi and Guérin
We thank Drs Santini, Votta and Protti for their comments on our letter about the impact of end-inspiratory plateau pressure duration on driving pressure (∆P) value. They were wondering if driving pressure should be calculated as the difference between P1 (airway pressure at first zero flow) and PEEP.
P1 to plateau pressure decay results from two mechanisms: (1) visco-elastic properties of the lung and chest wall tissues, and (2) pendelluft phenomenon [4, 5]. Since the static inspiratory equilibrium is reached at the time of plateau pressure, it turns out that, stricto sensu, it is only ∆P computed with plateau pressure that really reflects the elastic properties of the lung. On the other hand, the heterogeneous ARDS lung is characterized by time constant inequalities. Hence, it turns out that, stricto sensu, it is only ∆P computed with P1 that reflects the overall elastic load and also the viscoelastic properties of lung and chest wall tissues.
Nonetheless, we performed a supplementary analysis of our dataset and computed ∆P with P1 (“dynamic” ∆P) and PEEP set on the ventilator, and compared it with the Amato ∆P definition. Bland–Altman analysis revealed that, at low PEEP, “dynamic” ∆P was 1.8 CI 95% (−1.6 to 5.3) cmH2O higher than Amato ∆P and both were highly correlated (R 2 0.97; P 10–13). At high PEEP, these values were 1.6 CI 95% (−2.1 to 5.2) cmH2O (R 2 0.95; P < 10–7). Therefore, we are not sure that “dynamic” ∆P brings additional information as compared to the Amato ∆P definition.
References
Mezidi M, Yonis H, Aublanc M et al (2016) Effect of end-inspiratory plateau pressure duration on driving pressure. Intensive Care Med 43:587–589. doi:10.1007/s00134-016-4651-6
D’Angelo E, Calderini E, Torri G et al (1989) Respiratory mechanics in anesthetized paralyzed humans: effects of flow, volume, and time. J Appl Physiol 67:2556–2564
Protti A, Maraffi T, Milesi M et al (2016) Role of strain rate in the pathogenesis of ventilator-induced lung edema. Crit Care Med 44(9):e838–e845
D’Angelo E, Robatto FM, Calderini E, Tavola M, Bono D, Torri G et al (1991) Pulmonary and chest wall mechanics in anesthetized paralyzed humans. J Appl Physiol 70(6):2602–2610
Eissa NT, Ranieri VM, Corbeil C, Chassé M, Robatto FM, Braidy J et al (1991) Analysis of behavior of the respiratory system in ARDS patients: effects of flow, volume, and time. J Appl Physiol 70(6):2719–2729
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Santini, A., Votta, E., Protti, A. et al. Driving airway pressure: should we use a static measure to describe a dynamic phenomenon?. Intensive Care Med 43, 1544–1545 (2017). https://doi.org/10.1007/s00134-017-4850-9
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DOI: https://doi.org/10.1007/s00134-017-4850-9