Skip to main content
SpringerLink
Log in

Endothelial injury in sepsis

  • What's New in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Aird WC (2001) Vascular bed-specific hemostasis: role of endothelium in sepsis pathogenesis. Crit Care Med 29:S28–S34

    Article  PubMed  CAS  Google Scholar 

  2. Levi M, van der Poll T, Schultz M (2012) New insights into pathways that determine the link between infection and thrombosis. Neth J Med 70:114–120

    PubMed  CAS  Google Scholar 

  3. Lowenberg EC, Meijers JC, Levi M (2010) Platelet-vessel wall interaction in health and disease. Neth J Med 68:242–251

    PubMed  CAS  Google Scholar 

  4. Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM (2002) The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit Care Med 30:S294–S301

    Article  PubMed  CAS  Google Scholar 

  5. Furie B, Furie BC (2004) Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation. Trends Mol Med 10:171–178

    Article  PubMed  CAS  Google Scholar 

  6. Moake JL (2002) Thrombotic microangiopathies. N Engl J Med 347:589–600

    Article  PubMed  CAS  Google Scholar 

  7. Bockmeyer CL, Claus RA, Budde U, Kentouche K, Schneppenheim R, Reinhart K, Brunkhorst FM (2008) Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor. Haematologica 93:137–140

    Article  PubMed  CAS  Google Scholar 

  8. Booth KK, Terrell DR, Vesely SK, George JN (2011) Systemic infections mimicking thrombotic thrombocytopenic purpura. Am J Hematol 86:743–751

    Article  PubMed  Google Scholar 

  9. Fuchs TA, Brill A, Wagner DD (2012) Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler Thromb Vasc Biol 32:1777–1783

    Article  PubMed  CAS  Google Scholar 

  10. Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, Lohmeyer J, Preissner KT (2012) Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS One 7:e32366

    Article  PubMed  CAS  Google Scholar 

  11. Levi M, van der Poll T (2010) Inflammation and coagulation. Crit Care Med 38:S26–S34

    Article  PubMed  CAS  Google Scholar 

  12. Coughlin SR (2000) Thrombin signalling and protease-activated receptors. Nature 407:258–264

    Article  PubMed  CAS  Google Scholar 

  13. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR (2006) Roles of protease-activated receptors in a mouse model of endotoxemia. Blood 107:3912–3921

    Article  PubMed  CAS  Google Scholar 

  14. Mause SF, Weber C (2010) Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res 107:1047–1057

    Article  PubMed  CAS  Google Scholar 

  15. Meziani F, Delabranche X, Asfar P, Toti F (2010) Bench-to-bedside review: circulating microparticles—a new player in sepsis? Crit Care 14:236

    Article  PubMed  Google Scholar 

  16. Delabranche X, Boisrame-Helms J, Asfar P, Berger A, Mootien Y, Lavigne T, Grunebaum L, Lanza F, Gachet C, Freyssinet JM, Toti F, Meziani F (2013) Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy. Intensive Care Med

Download references

Conflicts of interest

No conflict of interest.

Author information

Authors and Affiliations

  1. Department of Medicine, Academic Medical Center, University of Amsterdam (E-2), Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    Marcel Levi & Tom van der Poll

Authors
  1. Marcel Levi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tom van der Poll
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marcel Levi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Levi, M., van der Poll, T. Endothelial injury in sepsis. Intensive Care Med 39, 1839–1842 (2013). https://doi.org/10.1007/s00134-013-3054-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-013-3054-1

Keywords

Search

Navigation