Abstract
To evaluate the satisfaction of clinical scientists when submitting study drafts to an ethics committee/clinical trials register (CLINICALTRIALS, EUDRACT, ISRCTN) we conducted an online survey of 240 authors publishing in anesthesia/critical care medicine (A) or in major general medical (M) journals from January to December 2007. No statistical difference between groups A and M was seen with regard to the number of studies submitted to ethics committees or registered in various clinical trials registers. On a visual analogue scale (VAS −10 to +10), the subjective evaluation of the effort required to submit a study draft to an ethics committee or enter it in a clinical trials register produced almost only negative grades in both groups. The mean different perceptions ranged from −3.5 to −0.1 in group A and from −4.4 to −0.2 (except for +0.1 and 1.9 in 2 subgroups) in group M. The authors in both groups gave a positive score to the better transparency in scientific research resulting from introduction of the clinical trials registers (+2.4 in group A, +4.8 in group M). The results of our study indicate widespread author dissatisfaction when submitting a clinical trial to ethics committees or clinical trials registers.
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The authors declare that they have no conflict of interest.
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This article is discussed in the editorial available at: doi: 10.1007/s00134-009-1435-2.
All authors have contributed equally to the study.
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Pehboeck, D., Hohlrieder, M., Wenzel, V. et al. Submission of clinical studies to ethics committees or clinical trials registers: the authors’ point of view. Intensive Care Med 35, 713–716 (2009). https://doi.org/10.1007/s00134-009-1434-3
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DOI: https://doi.org/10.1007/s00134-009-1434-3