Sir: We read with great interest the contribution by Morris et al. [1]. The authors and the United Kingdom Paediatric Traumatic Brain Injury (TBI) Study Group need to be congratulated on setting up this databank, providing useful information regarding severe traumatic brain injury in children. The objective of the study was to identify factors associated with the use of intracranial pressure (ICP) monitoring and to determine what ICP-targeted therapies are being used in children with severe TBI. The authors observed that ICP monitoring was undertaken in 45% of cases, and this increased to 59% in those with an emergency room Glasgow Coma Score of 8 or below. First-tier ICP targeted therapy was found to differ substantially between centers. Finally, the authors advocated the use of ICP monitoring and targeted therapy and concluded that less variation in management could have a beneficial effect on outcome.

Despite widespread recommendation by experts in the field there is no sound evidence that monitoring of ICP and ICP-targeted therapy improve outcome [2]. Recently a retrospective cohort study in two level I trauma centers in The Netherlands from 1996 to 2001 determined the effect of ICP-targeted therapy on functional outcome in severely head-injured adults [3]. In center A therapeutic interventions were based on clinical observations and computed tomography findings, whereas in center B management was aimed at maintaining ICP below 20 mmHg and CPP above 70 mmHg. In-hospital mortality rate was 41 (34%) vs. 69 (33%, p = 0.87). The odds ratio for a more favorable functional outcome following ICP/CPP-targeted therapy was 0.95 (95% confidence interval 0.62–1.44). This result remained after adjustment for potential confounders. Sedatives, vasopressors, mannitol, and barbiturates were much more frequently used in center B (all p = < 0.01).

In this respect it would have been very interesting if the authors had provided additional information on outcome between the groups, in particular for patients with an emergency room Glasgow Coma Score of 8 or below, for example, on whether was there a difference in death due to incarnation, in-hospital mortality, and neurological outcome. This additional information would provide at least some indication whether ICP-targeted therapy improves mortality and neurological outcome.