Mutagenicity and Genotoxicity in Gill Erythrocyte Cells of Poecilia reticulata Exposed to a Glyphosate Formulation

  • José De Souza Filho
  • Caio César Neves Sousa
  • Cláudio Carlos Da Silva
  • Simone Maria Teixeira De Sabóia-Morais
  • Cesar Koppe Grisolia
Article

DOI: 10.1007/s00128-013-1103-7

Cite this article as:
De Souza Filho, J., Sousa, C.C.N., Da Silva, C.C. et al. Bull Environ Contam Toxicol (2013) 91: 583. doi:10.1007/s00128-013-1103-7

Abstract

Poecilia reticulata were exposed to herbicide Roundup Transorb® for micronucleus test, nuclear abnormalities and comet assay. The exposure-concentrations were based on CL50–96 h following 0, 1.41, 2.83, 4.24 and 5.65 μL L−1 for 24 h. Micronucleus and comets were significantly increased in the gill erythrocyte cells after herbicide exposure compared with the non-exposed group. Results showed a gradual increase in the number of damaged cells, indicating a concentration-dependent effect and that this herbicide was mutagenic and genotoxic to P. reticulata and this effect could be attributed to a combination of compounds contained in the formulation with the active ingredient glyphosate.

Keywords

Roundup Transorb® Comet assay Micronucleus Glyphosate formulations 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • José De Souza Filho
    • 1
  • Caio César Neves Sousa
    • 2
  • Cláudio Carlos Da Silva
    • 2
  • Simone Maria Teixeira De Sabóia-Morais
    • 3
  • Cesar Koppe Grisolia
    • 1
  1. 1.Departamento de Genética e Morfologia, Instituto de Ciências BiológicasUniversidade de BrasíliaBrasíliaBrazil
  2. 2.Departamento de BiologiaUniversidade Católica de GoiásGoiâniaBrazil
  3. 3.Instituto de Ciências BiológicasUniversidade Federal de GoiásGoiâniaBrazil

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