Abstract
This study was conducted to investigate time-dependent changes in oxidative enzymes in liver of crucian carp after intraperitoneally injection with extracted microcystins 600 and 150 μg kg−1 body weight. The results showed that activities of antioxidant enzymes, including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase generally exhibited a rapid increase in early phase (1–3 h post injection), but gradually decreased afterwards (12–48 h) compared with the control, with an evident time-dependent effect. These zigzag changes over time contributed a better understanding on oxidative stress caused by microcystins in fish.
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Acknowledgments
We would like to express our sincere thanks to Dr. Herbert N. Nigg and anonymous reviewers for their useful comments and suggestions on the manuscript. This study is supported by a fund for lecture professor from Huazhong Agricultural University and the National Natural Science Foundation of China (30530170).
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Zhang, X., Xie, P., Li, D. et al. Time-Dependent Oxidative Stress Responses of Crucian Carp (Carassius auratus) to Intraperitoneal Injection of Extracted Microcystins. Bull Environ Contam Toxicol 82, 574–578 (2009). https://doi.org/10.1007/s00128-009-9671-2
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DOI: https://doi.org/10.1007/s00128-009-9671-2