Abstract
Purpose
Incidence rates of psychotic disorders are higher in immigrant groups compared to native populations. This increased risk may partly be explained by misdiagnosis. Neurocognitive deficits are a core feature of psychotic disorders, but little is known about the relationship between migration and cognition in psychotic disorders. We examined whether immigrant patients have cognitive deficits similar to non-immigrant patients, in order to investigate the plausibility of misdiagnosis as explanation for increased incidence rates.
Methods
Patients who made first contact for non-affective psychotic disorder were assessed in the cognitive domains sustained attention, immediate recall and delayed recall. Immigrant patients were compared to Dutch patients on cognitive performance.
Results
407 Patients diagnosed with a non-affective psychotic disorder completed cognitive assessment (157 Dutch, 250 immigrants). Both Dutch and immigrant patients showed large cognitive deficits. Between-subgroup comparisons revealed large cognitive deficits for immigrants compared to Dutch, especially for immigrants from Morocco, Turkey and other non-Western countries.
Conclusions
These results indicate that immigrant status is associated with poorer cognitive functioning in early psychosis. The findings argue against diagnostic bias as an explanation for the increased incidence of psychotic disorders in immigrants.
Similar content being viewed by others
References
Selten JP, Veen N, Feller W, Blom JD, Schols D, Camoenië W, Oolders J, Van der Velden M, Hoek HW, Vladar Rivero VM, Van der Graaf Y, Kahn R (2001) Incidence of psychotic disorders in immigrant groups to The Netherlands. Br J Psychiatry 178:367–372
McGrath J, Saha S, Welham J, El Saadi O, MacCauley C, Chant D (2004) A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med 2:13
Cantor-Graae E, Selten JP (2005) Reviews and overviews schizophrenia and migration: a meta-analysis and review psychiatry. Interpers Biol Process 162:12–24
Cantor-Graae E, Selten JP (2005) Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry 162:12–24
Kirkbride JB, Fearon P, Morgan C, Dazzan P, Morgan K, Tarrant J, Lloyd T, Holloway J, Hutchinson G, Leff JP, Mallett RM, Harrison GL, Murray RM, Jones PB (2006) Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study. Arch Gen Psychiatry 63:250–258
Veling W, Selten JP, Veen N, Laan W, Blom JD, Hoek HW (2006) Incidence of schizophrenia among ethnic minorities in the Netherlands: a four-year first-contact study. Schizophr Res 86:189–193
Veling W, Selten JP, Susser E, Laan W, Mackenbach JP, Hoek HW (2007) Discrimination and the incidence of psychotic disorders among ethnic minorities in The Netherlands. Int J Epidemiol 36:761–768
Bourque F, Van der Ven E, Malla A (2011) A meta-analysis of the risk for psychotic disorders among first- and second-generation immigrants. Psychol Med 41:897–910
Jarvis GE, Toniolo I, Ryder AG, Sessa F, Cremonese C (2011) High rates of psychosis for black inpatients in Padua and Montreal: different contexts, similar findings. Soc Psychiatry Psychiatric Epidemol 46:247–253
Selten JP, Hoek HW (2008) Does misdiagnosis explain the schizophrenia epidemic among immigrants from developing countries to Western Europe? Soc Psychiatry Psychiatric Epidemol 43:937–939
Zandi T, Havenaar JM, Smits M, Limburg-Okken AG, Van Es H, Cahn W, Algra A, Kahn RS, Van Den Brink W (2010) First contact incidence of psychotic disorders among native Dutch and Moroccan immigrants in the Netherlands: influence of diagnostic bias. Schizophr Res 119:27–33
Sharpley M, Hutchinson G, McKenzie K, Murray RM (2001) Understanding the excess of psychosis among the African-Caribbean population in England review of current hypotheses. Br J Psychiatry 40:60–68
Arnold LM, Keck PE, Collins J, Wilson R, Fleck DE, Corey KB, Amicone J, Adebimpe VR, Strakowski SM (2004) Ethnicity and first-rank symptoms in patients with psychosis. Schizophr Res 67:207–212
Veling W, Selten JP, Mackenbach JP, Van Os J, Hoek HW (2007) Symptoms at first contact for psychotic disorder: comparison between native Dutch and ethnic minorities. Schizophr Res 95:30–38
Van Os J, Kapur S (2009) Schizophrenia. Lancet 374:635–645
Green MF (1996) What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 153:321–330
Mesholam-gately RI, Giuliano AJ, Goff KP, Faraone SV, Seidman LJ (2009) Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychol 23(3):315–336
Braff DL, Greenwood T, Swerdlow N, Light G, Schork N (2008) Advances in endophenotyping schizophrenia. World Psychiatry 12:11–18
Heinrichs RW, Zakzanis KK (1998) Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychol 12:426–445
Aleman A, Hijman R, De Haan EH, Kahn RS (1999) Memory impairment in schizophrenia: a meta-analysis. Am J Psychiatry 156:1358–1366
Niemi L, Suvisaari J, Tuuliohenriksson A, Lonnqvist J (2003) Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies. Schizophr Res 60:239–258
Cornblatt B, Obuchowski M, Roberts S, Pollack S, Erlenmeyer-Kimling L (1999) Cognitive and behavioral precursors of schizophrenia. Dev Psychopathol 11:487–508
Niendam TA, Bearden CE, Johnson JK, Mckinley M, Loewy R, O’Brien M, Nuechterlein KH, Green MF, Cannon TD (2006) Neurocognitive performance and functional disability in the psychosis prodrome. Schizophr Res 84:100–111
Seidman LJ, Cassens G, Kremen WS, Pepple JR (1992) The neuropsychology of schizophrenia In: White RF (ed) Clinical syndromes in adult neuropsychology: the practitioner handbook. Elsevier, Amsterdam, pp 381–445
Krabbendam L, Arts B, Os JV (2005) Cognitive functioning in patients with schizophrenia and bipolar disorder: a quantitative review. Schizophr Res 80:137–149
Stefanopoulou E, Manoharan A, Landau S, Geddes JR, Goodwin G, Frangou S (2009) Cognitive functioning in patients with affective disorders and schizophrenia: a meta-analysis. Int Rev Psychiatry 21(4):336–356
Boone K, Victor TL, Wen J, Razani J, Pontón M (2007) The association between neuropsychological scores and ethnicity, language, and acculturation variables in a large patient population. Arch Clin Neuropsychol 22:355–365
Te Nijenhuis J, Van Vlier H (2001) Group differences in mean intelligence for the Dutch and third-world immigrants. J Biosoc Sci 33:469–475
Andreasen NC, Flaum M, Arndt D (1992) The Comprehensive Assessment of Symptoms and History (CASH) an instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry 49:615–623
World Health Organisation (1992) Schedules for clinical assessment in neuropsychiatry. World Health Organisation, Geneva
Häfner H, Riecher-Rössler A, Hambrecht M, Maurer K, Meissner S, Schmidtke A, Fätkenheuer B, Löffler W, Van der Heiden W (1992) IRAOS: an instrument for the assessment of onset and early course of schizophrenia. Schizophr Res 6:209–223
Kalverboer AF, Deelman BG (1964) De nieuwe vijftien woordentest A en B, handboek (adapted in 1986), UMC Groningen
(1995) CPT 3-7 version 3.0 for MS-DOS, Berisoft Cooperation, Germany
Rey A (1941) L’examen psychologique dans les cas d’enc′ephalopathie traumatique. Arch de Psychol 28:286–340
Neuchterlein KH, Edell WS, Norris M, Dawson ME (1986) Attentional vulnerability indicators, thought disorder, and negative symptoms. Schizophr Bull 12:408–426
Rosvold HE, Mirsky AF, Sarason I, Bransome ED Jr, Beck LH (1956) A continuous performance test of brain damage. J Consult Psychol 20:343–350
American Psychiatric Association (2000) DSM-IV-TR. p 34
(2010) SPSS for windows release 1803, SPSS Inc, Chicago
Cleary TA (1968) Test bias: prediction of grades of Negro and White students in integrated colleges. J Educ Meas 5:115–124
Pedraza O, Mungas D (2008) Measurement in cross-cultural neuropsychology. Neuropsychol Rev 18:184–193
Li-Jun J, Zhang Z, Nisbett RE (2004) Is it culture of is it language? Examination of language effects in cross-cultural research on categorization. J Personal Soc Psychol 87:57–65
Yücel M, Bora E, Lubman D, Solowij N, Brewer WJ, Cotton SM, Conus P, Takagi MJ, Fornito A, Wood SJ, McGorry PD, Pantelis C (2012) The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample. Schizophr Bull 38:316–330
Markus HR, Kitayama S (1991) Culture and the self: implications for cognition, emotion and motivation. Psychol Rev 98:224–253
Knight KN, Nisbett RE (2007) Culture, class, and cognition: evidence from Italy. J Cogn Cult 7:283–291
Kitayama S, Park J (2010) Cultural neuroscience of the self: understanding the social grounding of the brain. SCAN 5:111–129
Park DC, Huang CM (2010) Culture wires the brain: a cognitive neuroscience perspective. Persp Psychol Sci 5:391–400
Varnum MEW, Grossman I, Kitayama S, Nisbett RE (2010) The origin of cultural differences in cognition: the social orientation hypothesis. Curr Dir Psychol Sci 19:9–13
Nisbett RE, Peng K, Choi I, Norenzayan A (2001) Culture and systems of thought: holistic vs analytic cognition. Psychol Rev 108:291–310
Nisbett RE (2003) The geography of thought: how Asians and Westerners think differently… and why. Free press, New York
Masuda T, Nisbett RE (2001) Attending holistically vs analytically: comparing the context sensitivity of Japanese and Americans. J Personal Soc Psychol 81:922–934
Kitayama S, Duffy S, Kawamura T, Larsen JT (2003) A cultural look at New Look: perceiving an object and its context in two cultures. Psychol Sci 14:201–206
Chua HF, Boland JE, Nisbett RE (2005) Cultural variation in eye movements during scene perception. Proc Natl Acad Sci USA 102:12629–12633
Steele CM, Aronson J (1995) Stereotype threat and the intellectual test performance of African Americans. J Pers Soc Psychol 5:797–811
Chakraborty A, King M, Leavey G (2011) Perceived racism, medication adherence, and hospital admission in African-Caribbean patients with psychosis in the United Kingdom. Soc Psychiatry Psychiatric Epidemol 46:915–923
Veling W, Hoek ÆHW, Mackenbach ÆJP (2008) Perceived discrimination and the risk of schizophrenia in ethnic minorities. Soc Psychiatry Psychiatric Epidemol 43:953–959
Veling W, Susser E, Van Os J, Mackenbach JP, Selten JP, Hoek HW (2008) Ethnic density of neighborhoods and incidence of psychotic disorders among immigrants. Am J Psychiatry 165:66–73
Schmader T, Johns M, Forbes C (2008) An integrated process model of stereotype threat effects on performance. Psychol Rev 2:336–356
Boydell J, Van Os J, McKenzie K, Allardyce J, Goel R, McCreadie RG, Murray RM (2001) Incidence of schizophrenia in ethnic minorities in London: ecological study into interactions with environment. Br J Psychiatry 323:1336–1338
Rutter M, Tienda M (2005) Ethnicity and causal mechanisms. Cambridge University Press, Cambridge
Halpern D (1993) Minorities and mental health. Soc Sci Med 36:597–607
Mishara AL, Goldberg TE (2004) A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: opening a closed book. Biol Psychiatry 55:1013–1022
Woodward ND, Purdon SE, Meltzer HY, Zald DH (2007) A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose-effect and comparison to practice effects. Schizophr Res 89:211–224
Acknowledgments
We thank Jurre Wiersma, who kindly assisted in pre-structuring our data and Niels Smits, for his valuable feedback on the statistical analysis. We also thank Johanna Stouten and Myrle Kemperman for their assistance with the proof-reading of the manuscript.
Conflict of interest
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Stouten, L.H., Veling, W., van der Helm, M. et al. Cognitive deficits and ethnicity: a cohort study of early psychosis patients in The Netherlands. Soc Psychiatry Psychiatr Epidemiol 48, 37–47 (2013). https://doi.org/10.1007/s00127-012-0521-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00127-012-0521-x