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An explanation for recent discrepancies in levels of human circulating betatrophin

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Fig. 1

Abbreviations

ANGPTL:

Angiopoietin-like protein

LPL:

Lipoprotein lipase

References

  1. Zhang R (2012) Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun 424:786–792

    Article  CAS  PubMed  Google Scholar 

  2. Ren G, Kim JY, Smas CM (2012) Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab 303:E334–E351

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Quagliarini F, Wang Y, Kozlitina J et al (2012) Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A 109:19751–19756

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Wang Y, Quagliarini F, Gusarova V et al (2013) Mice lacking ANGPTL8 (betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A 110:16109–16114

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Yi P, Park JS, Melton DA (2013) Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 153:747–758

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Espes D, Lau J, Carlsson PO (2014) Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes. Diabetologia 57:50–53

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Fenzl A, Itariu BK, Kosi L et al (2014) Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals. Diabetologia 57:1204–1208

    Article  CAS  PubMed  Google Scholar 

  8. Espes D, Martinell M, Carlsson PO (2014) Increased circulating betatrophin concentrations in patients with type 2 diabetes. Int J Endocrinol 2014:323407

    Article  PubMed Central  PubMed  Google Scholar 

  9. Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R (2014) Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Sci Rep 4:5013

    PubMed  Google Scholar 

  10. Chang JK, Lyu RM, Chen XQ et al (2013) Detection of C-terminal betatrophin peptides in human plasma and rodent liver. In: Nishiuchi Y, Teshima T (eds) The 4th Asia-Pacific International Peptide Symposium. Peptide Science, Japan, pp 243–246

    Google Scholar 

  11. Gómez-Ambrosi J, Pascual E, Catalán V et al (2014) Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes. J Clin Endocrinol Metab (in press)

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Note added in proof

Consistent with the result of negative correlation between betatrophin and BMI based on the N-terminal kit (Fig. 1c), in a recent study, Gómez-Ambrosi et al [11] showed that circulating betatrophin is decreased in obesity.

Funding

This work was supported by a startup fund from Wayne State University to RZ.

Duality of interest

The authors confirm that there is no duality of interest associated with this manuscript.

Contribution statement

ZF performed the experiments, analysed the data and participated in manuscript revision. ABA-S participated in data analysis and manuscript revision. RZ designed the study, analysed the data and wrote the manuscript. All authors have approved the final version. RZ is the guarantor of this work.

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Authors and Affiliations

  1. Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, 540 East Canfield Street, Detroit, MI, 48201, USA

    Zhiyao Fu, Abdul B. Abou-Samra & Ren Zhang

  2. Department of Medicine, Hamad Medical Corporation, Doha, Qatar

    Abdul B. Abou-Samra

Authors
  1. Zhiyao Fu
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  2. Abdul B. Abou-Samra
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  3. Ren Zhang
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Corresponding author

Correspondence to Ren Zhang.

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Fu, Z., Abou-Samra, A.B. & Zhang, R. An explanation for recent discrepancies in levels of human circulating betatrophin. Diabetologia 57, 2232–2234 (2014). https://doi.org/10.1007/s00125-014-3346-1

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  • DOI: https://doi.org/10.1007/s00125-014-3346-1

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