Skip to main content
Log in

Polypharmazie und Medikamentencheck im Kontext der Prähabilitation

Polypharmacy and medication review in the context of prehabilitation

  • Leitthema
  • Published:
Die Urologie Aims and scope Submit manuscript

Zusammenfassung

Vor dem Hintergrund der geriatrietypischen Multimorbidität einerseits und der besonderen Vulnerabilität des geriatrischen Patienten andererseits verdient die Multimedikation eine besondere Beachtung. Leitliniengerecht soll eine Überprüfung der Medikation nicht nur regelmäßig, sondern auch anlassbezogen und bei jedem Krankenhausaufenthalt vorgenommen werden – also auch im Kontext einer Prähabilitation. Dabei verdienen nicht nur Substanzen, die mit dem eigentlich geplanten Eingriff, der Narkose oder dem Blutungsrisiko interferieren eine Rolle, sondern jede Medikation, die die typischen Risiken für einen geriatrischen Patienten erhöhen. Dazu zählen Präparate, die eine Sturzneigung verursachen oder verstärken, ein Delir auslösen können oder aber durch pharmakologische Interaktionen die Komedikation verändern. Maßnahmen, die das Risiko minimieren können, sind die exakte Dokumentation einer Medikation, die strukturierte und komplette Informationsweitergabe, die Patienten- und Angehörigenschulung über evtl. auftretende Nebenwirkungen, ein Recall-System z. B. für etwaige Laborkontrollen und die Beachtung der Einnahmevorschriften.

Abstract

Against the background of typical geriatric multimorbidity and with the particular vulnerability of geriatric patients, polypharmacy deserves special attention. In accordance with the guidelines, medication should not only be reviewed regularly, but also on an ad hoc basis and with each hospital stay—and also in the context of prehabilitation. Thus, not only substances that interfere with the currently planned intervention, anesthesia, or risk of bleeding should be considered, but any medication that increases common risks for geriatric patients. These include drugs that cause or increase a tendency to fall, induce delirium, or alter the comedication through potential drug–drug interactions. Measures to minimize the risk include the following: exact documentation of medications, structured and complete transfer of information, patient and family training about any side effects that may occur, a recall system for possible laboratory checks, and compliance with the instructions for taking the medication.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Moran J, Guinan E, McCormick P et al (2016) The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: a systematic review and meta-analysis. Surgery 160:1189–1201

    Article  PubMed  Google Scholar 

  2. Wiedemann A, Gleisner J, Karstedt H et al (2018) Geriatric urology : Definition. Urologe A 57:389

    Article  CAS  PubMed  Google Scholar 

  3. Wiedemann A, Puttmann J, Heppner H (2019) The ISAR-positive patient in urology. Aktuelle Urol 50:100–105

    Article  PubMed  Google Scholar 

  4. Child CG, Turcotte JG (1964) Surgery and portal hypertension. Major Probl Clin Surg 1:1–85

    CAS  PubMed  Google Scholar 

  5. von Haehling S, Morley JE, Anker SD (2010) An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle 1:129–133

    Article  Google Scholar 

  6. Stanaway FF, Gnjidic D, Blyth FM et al (2011) How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ 343:d7679

    Article  PubMed  PubMed Central  Google Scholar 

  7. Rassam Y, Schindler A, Willschrei P, Horstmann M (2020) The G8 questionnaire as a geriatric screening tool in urooncology. Aktuelle Urol 51:36–41

    PubMed  Google Scholar 

  8. Podsiadlo D, Richardson S (1991) The timed „Up & Go“: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39:142–148

    Article  CAS  PubMed  Google Scholar 

  9. Shulman KI (2000) Clock-drawing: is it the ideal cognitive screening test? Int J Geriatr Psychiatry 15:548–561

    Article  CAS  PubMed  Google Scholar 

  10. Folstein MF, Folstein SE, McHugh PR (1975) „Mini-mental state“. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198

    Article  CAS  PubMed  Google Scholar 

  11. Tanaka T, Takahashi K, Akishita M, Tsuji T, Iijima K (2018) „Yubi-wakka“ (finger-ring) test: A practical self-screening method for sarcopenia, and a predictor of disability and mortality among Japanese community-dwelling older adults. Geriatr Gerontol Int 18:224–232

    Article  PubMed  Google Scholar 

  12. Wiedemann A (2018) Geriatric assessment in urology. Urologe A 57:1257–1270

    Article  PubMed  Google Scholar 

  13. Ang-Lee MK, Moss J, Yuan CS (2001) Herbal medicines and perioperative care. JAMA 286:208–216

    Article  CAS  PubMed  Google Scholar 

  14. Lassemillante AC, Doi SA, Hooper JD, Prins JB, Wright OR (2015) Prevalence of osteoporosis in prostate cancer survivors II: a meta-analysis of men not on androgen deprivation therapy. Endocrine 50:344–354

    Article  CAS  PubMed  Google Scholar 

  15. Smith MR, Saad F, Chowdhury S et al (2018) Apalutamide treatment and metastasis-free survival in prostate cancer. N Engl J Med 378:1408–1418

    Article  CAS  PubMed  Google Scholar 

  16. Kuschel BM, Laflamme L, Moller J (2015) The risk of fall injury in relation to commonly prescribed medications among older people−a Swedish case-control study. Eur J Public Health 25:527–532

    Article  PubMed  Google Scholar 

  17. Corrao G, Mazzola P, Monzio Compagnoni M et al (2015) Antihypertensive medications, loop diuretics, and risk of hip fracture in the elderly: a population-based cohort study of 81,617 Italian patients newly treated between 2005 and 2009. Drugs Aging 32:927–936

    Article  CAS  PubMed  Google Scholar 

  18. Iglseder B, Fruhwald T, Jagsch C (2022) Delirium in geriatric patients. Wien Med Wochenschr 172:114–121

    Article  PubMed  PubMed Central  Google Scholar 

  19. Sanyaolu L, Scholz AFM, Mayo I et al (2020) Risk factors for incident delirium among urological patients: a systematic review and meta-analysis with GRADE summary of findings. BMC Urol 20:169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Yu CP, Yang MS, Hsu PW, Lin SP, Hou YC (2021) Bidirectional influences of cranberry on the pharmacokinetics and pharmacodynamics of warfarin with mechanism elucidation. Nutrients. https://doi.org/10.3390/nu13093219

    Article  PubMed  PubMed Central  Google Scholar 

  21. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH (2003) Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 163:2716–2724

    Article  PubMed  Google Scholar 

  22. Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC (1991) Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch Intern Med 151:1825–1832

    Article  CAS  PubMed  Google Scholar 

  23. Mann NK, Mathes T, Sonnichsen A, Pieper D, Klager E, Moussa M, Thürmann PA (2023) Potentially inadequate medications in the elderly: PRISCUS 2.0-first update of the PRISCUS list. Dtsch Ärztebl Int. https://doi.org/10.3238/arztebl.m2022.0377

  24. Schubert I, Hein R, Abbas S, Thurmann P (2012) The frequency of prescription of immediate-release nifedipine for elderly patients in Germany: utilization analysis of a substance on the PRISCUS list of potentially inappropriate medications. Dtsch Ärztebl Int 109:215–219

    PubMed  PubMed Central  Google Scholar 

  25. Holt S, Schmiedl S, Thurmann PA (2010) Potentially inappropriate medications in the elderly: the PRISCUS list. Dtsch Ärztebl Int 107:543–551

    PubMed  PubMed Central  Google Scholar 

  26. Pazan F, Weiss C, Wehling M, Forta (2016) The FORTA (Fit fOR The Aged) list 2015: update of a validated clinical tool for improved pharmacotherapy in the elderly. Drugs Aging 33:447–449

    Article  PubMed  Google Scholar 

  27. Wehling M (2008) Drug therapy in the elderly: too much or too little, what to do? A new assessment system: fit for the aged (FORTA). Dtsch Med Wochenschr 133:2289–2291

    Article  CAS  PubMed  Google Scholar 

  28. Boustani M, Munger S, Beck R, Campbell N, Weiner M (2007) A gero-informatics tool to enhance the care of hospitalized older adults with cognitive impairment. Clin Interv Aging 2:247–253

    PubMed  PubMed Central  Google Scholar 

  29. Wiedemann A, Dundar V, Heese M et al (2021) Adverse drug reaction affecting the urinary tract−the Witten urinary tract adverse reaction score. Aktuelle Urol 52:481–489

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Wiedemann.

Ethics declarations

Interessenkonflikt

Angaben zum Interessenkonflikt s. Tab. 5.

Tab. 5 Einhaltung ethischer Richtlinien

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Additional information

Die Autoren T.H. Kuru und J. Salem haben zu gleichen Teilen zum Manuskript beigetragen.

figure qr

QR-Code scannen & Beitrag online lesen

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wiedemann, A., Stein, J., Manseck, A. et al. Polypharmazie und Medikamentencheck im Kontext der Prähabilitation. Urologie 62, 1025–1033 (2023). https://doi.org/10.1007/s00120-023-02174-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00120-023-02174-6

Schlüsselwörter

Keywords

Navigation