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S2e-Leitlinie der Deutschen Urologen

Instrumentelle Therapie des benignen Prostatasyndroms

S2e guideline of the German urologists

Instrumental treatment of benign prostatic hyperplasia

  • Leitlinien der DGU und des BDU
  • Published:
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Zusammenfassung

Diese Übersicht fasst die relevanten Aspekte der S2e-Leitlinie der Deutschen Urologen zur instrumentellen Therapie des benignen Prostatasyndroms (BPS) zusammen. Empfehlungen zu offenen und transurethralen Verfahren (TUR-P, bipolare TUR-P, TUI-P, HE-TUMT, TUNA und den unterschiedlichen Laserverfahren) werden gegeben. Darüber hinaus finden sich Empfehlungen zu intraprostatischen Stents und Injektionstherapien. Die Arbeit stellt zudem detailliert den Einfluss der unterschiedlichen Therapieoptionen auf die Blasenauslassobstruktion (BOO) dar.

Abstract

This report summarizes the relevant aspects of the S2e guideline of the German Urologists for the instrumental treatment of the lower urinary tract symptoms due to benign prostatic hyperplasia. Recommendations are given regarding open and transurethral procedures (TUR-P, bipolar TUR-P, TUI-P, HE-TUMT, TUNA, and the different Laser techniques). Recommendations are also given concerning intraprostatic stents and injection therapies. The influence of the different therapeutic options on bladder outlet obstruction (BOO) is described in detail.

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Literatur

  1. Abrams PH (1978) The urodynamic changes after prostatectomy. Urol Int 33:181

    Article  Google Scholar 

  2. Abrams PH, Farrar DJ, Turner-Warwick RT et al (1979) The results of prostatectomy: a symptomatic and urodynamic analysis of 152 patients. J Urol 121:640–642

    CAS  PubMed  Google Scholar 

  3. Ahmed M, Bell T, Lawrence WT et al (1997) Transurethral microwave thermotherapy (Prostatron version 2.5) compared with transurethral resection of the prostate for the treatment of benign prostatic hyperplasia: a randomized, controlled, parallel study. Br J Urol 79:181–185

    Article  CAS  PubMed  Google Scholar 

  4. Aho TF, Gilling PJ, Kennett KM et al (2005) Holmium laser bladder neck incision versus holmium enucleation of the prostate as outpatient procedures for prostates less than 40 grams: a randomized trial. J Urol 174:210–214

    Article  PubMed  Google Scholar 

  5. Ahyai SA, Lehrich K, Kuntz RM (2007) Holmium laser enucleation versus transurethral resection of the prostate: 3-year follow-up results of a randomized clinical trial. Eur Urol 52:1456–1463

    Article  PubMed  Google Scholar 

  6. Armitage JN, Cathcart PJ, Rashidian A et al (2007) Epithelializing stent for benign prostatic hyperplasia: a systematic review of the literature. J Urol 177:1619–1624

    Article  CAS  PubMed  Google Scholar 

  7. AWMF (2014) AWMF-Register-Nummer 043-035, Aktualisierung 2014. AWMF, Düsseldorf. http://www.awmf.org/uploads/tx_szleitlinien/043-035m_S2e_Therapie_benignes_Prostatatasyndrom_2014_11.pdf

  8. AWMF (2014) AWMF, Düsseldorf. http://www.awmf.org/fileadmin/user_upload/Leitlinien/043_D_Ges_fuer_Urologie/043-035e1_S2e_Therapie_benignes_Prostatatasyndrom_2014_11.pdf

  9. AWMF (2014) AWMF, Düsseldorf. http://www.awmf.org/fileadmin/user_upload/Leitlinien/043_D_Ges_fuer_Urologie/043-035e2_S2e_Therapie_benignes_Prostatatasyndrom_2014_11.pdf

  10. AWMF (2014) AWMF, Düsseldorf. http://www.awmf.org/fileadmin/user_upload/Leitlinien/043_D_Ges_fuer_Urologie/043-035e3_S2e_Therapie_benignes_Prostatatasyndrom_2014_11.pdf

  11. Bach T, Herrmann TR, Ganzer R et al (2007) RevoLix vaporesection of the prostate: initial results of 54 patients with a 1-year follow-up. World J Urol 25:257–262

    Article  PubMed  Google Scholar 

  12. Bach T, Herrmann TR, Haecker A et al (2009) Thulium: yttrium-aluminium-garnet laser prostatectomy in men with refractory urinary retention. BJU Int 104:361–364

    Article  PubMed  Google Scholar 

  13. Bach T, Muschter R, Sroka R et al (2012) Laser treatment of benign prostatic obstruction: basics and physical differences. Eur Urol 61:317–325

    Article  PubMed  Google Scholar 

  14. Bach T, Netsch C, Haecker A et al (2010) Thulium: YAG laser enucleation (VapoEnucleation) of the prostate: safety and durability during intermediate-term follow-up. World J Urol 28:39–43

    Article  PubMed  Google Scholar 

  15. Bach T, Netsch C, Pohlmann L et al (2011) Thulium: YAG vapoenucleation in large volume prostates. J Urol 186:2323–2327

    Article  PubMed  Google Scholar 

  16. Bach T, Wendt-Nordahl G, Michel MS et al (2009) Feasibility and efficacy of Thulium: YAG laser enucleation (VapoEnucleation) of the prostate. World J Urol 27:541–545

    Article  CAS  PubMed  Google Scholar 

  17. Berges R, Dreikorn K, Hofner K et al (2009) Therapy of benign prostate syndrome (BPS): guidelines of the German Urologists (DGU). Urologe A 48:1503–1516

    Article  CAS  PubMed  Google Scholar 

  18. Berges R, Dreikorn K, Höfner K et al (2009) Diagnostik und Differenzialdiagnostik des benignen Prostatasyndroms (BPS): Leitlinien der Deutschen Urologen. Urologe A 48:1356–1360 (1362–1354)

    Article  CAS  PubMed  Google Scholar 

  19. Berges R, Dreikorn K, Höfner K et al (2009) Therapie des benignen Prostatasyndroms (BPS): Leitlinien der Deutschen Urologen. Urologe A 48:1503–1516

    Article  CAS  PubMed  Google Scholar 

  20. Bouchier-Hayes DM, Van Appledorn S, Bugeja P et al (2010) A randomized trial of photoselective vaporization of the prostate using the 80-W potassium-titanyl-phosphate laser vs transurethral prostatectomy, with a 1-year follow-up. BJU Int 105:964–969

    Article  PubMed  Google Scholar 

  21. Bouza C, Lopez T, Magro A et al (2006) Systematic review and meta-analysis of Transurethral Needle Ablation in symptomatic Benign Prostatic Hyperplasia. BMC Urol 6:14

    Article  PubMed  PubMed Central  Google Scholar 

  22. Brubaker L, Richter HE, Visco A et al (2008) Refractory idiopathic urge urinary incontinence and botulinum A injection. J Urol 180:217–222

    Article  PubMed  PubMed Central  Google Scholar 

  23. Bryan NP, Hastie KJ, Chapple CR (2000) Randomised prospective trial of contact laser prostatectomy (CLAP) versus visual laser coagulation of the prostate (VLAP) for the treatment of benign prostatic hyperplasia. 2-year follow-up. Eur Urol 38:265–271

    Article  CAS  PubMed  Google Scholar 

  24. Campo B, Bergamaschi F, Corrada P et al (1997) Transurethral needle ablation (TUNA) of the prostate: a clinical and urodynamic evaluation. Urology 49:847–850

    Article  CAS  PubMed  Google Scholar 

  25. Cannon A, Wildt M de, Abrams PH et al (1995) Urodynamics and laser prostatectomy. World J Urol 13:134–136

    Article  CAS  PubMed  Google Scholar 

  26. Capitan C, Blazquez C, Martin MD et al (2011) GreenLight HPS120-W laser vaporization versus transurethral resection of the prostate for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia: a randomized clinical trial with 2-year follow-up. Eur Urol 60:734–739

    Article  PubMed  Google Scholar 

  27. Castro JE (1973) The effect of prostatectomy on the symptoms and signs of benign prostatic hypertrophy. Br J Urol 45:428–431

    Article  CAS  PubMed  Google Scholar 

  28. Cavarretta L, Scremin E, Cucciarre G et al (2003) High-energy microwave thermotherapy in the treatment of benign prostatic hyperplasia. Urol Int 71:10–15

    Article  CAS  PubMed  Google Scholar 

  29. Chiang PH, Chen CH, Kang CH et al (2010) GreenLight HPS laser 120-W versus diode laser 200-W vaporization of the prostate: comparative clinical experience. Lasers Surg Med 42:624–629

    Article  PubMed  Google Scholar 

  30. Choe JM, Sirls LT (1996) High-energy visual laser ablation of the prostate in men with urinary retention: pressure-flow analysis. Urology 48:584–588

    Article  CAS  PubMed  Google Scholar 

  31. Cummings JM, Parra RO, Boullier JA (1995) Laser prostatectomy: initial experience and urodynamic follow-up. Urology 45:414–418 (discussion 418–420)

    Article  CAS  PubMed  Google Scholar 

  32. Dahlstrand C, Grundtman S, Pettersson S (1997) High-energy transurethral microwave thermotherapy for large severely obstructing prostates and the use of biodegradable stents to avoid catheterization after treatment. Br J Urol 79:907–909

    Article  CAS  PubMed  Google Scholar 

  33. Dmochowski R, Chapple C, Nitti VW et al (2010) Efficacy and safety of onabotulinumtoxinA for idiopathic overactive bladder: a double-blind, placebo controlled, randomized, dose ranging trial. J Urol 184:2416–2422

    Article  CAS  PubMed  Google Scholar 

  34. Dorflinger T, Jensen FS, Krarup T et al (1992) Transurethral prostatectomy compared with incision of the prostate in the treatment of prostatism caused by small benign prostate glands. Scand J Urol Nephrol 26:333–338

    Article  CAS  PubMed  Google Scholar 

  35. Dunsmuir WD, McFarlane JP, Tan A et al (2003) Gyrus bipolar electrovaporization vs transurethral resection of the prostate: a randomized prospective single-blind trial with 1 y follow-up. Prostate Cancer Prostatic Dis 6:182–186

    Article  CAS  PubMed  Google Scholar 

  36. Edwards L, Powell C (1982) An objective comparison of transurethral resection and bladder neck incision in the treatment of prostatic hypertrophy. J Urol 128:325–327

    CAS  PubMed  Google Scholar 

  37. Elmansy HM, Elzayat E, Elhilali MM (2010) Holmium laser ablation versus photoselective vaporization of prostate less than 60 cc: long-term results of a randomized trial. J Urol 184:2023–2028

    Article  PubMed  Google Scholar 

  38. Elzayat E, Habib E, Elhilali M (2006) Holmium laser enucleation of the prostate in patients on anticoagulant therapy or with bleeding disorders. J Urol 175:1428–1432

    Article  CAS  PubMed  Google Scholar 

  39. Elzayat EA, Al-Mandil MS, Khalaf I et al (2009) Holmium laser ablation of the prostate versus photoselective vaporization of prostate 60 cc or less: short-term results of a prospective randomized trial. J Urol 182:133–138

    Article  PubMed  Google Scholar 

  40. Elzayat EA, Habib EI, Elhilali MM (2005) Holmium laser enucleation of the prostate: a size-independent new „gold standard“. Urology 66:108–113

    Article  PubMed  Google Scholar 

  41. Fagerstrom T, Nyman CR, Hahn RG (2010) Bipolar transurethral resection of the prostate causes less bleeding than the monopolar technique: a single-centre randomized trial of 202 patients. BJU Int 105:1560–1564

    Article  PubMed  Google Scholar 

  42. Flynn MK, Amundsen CL, Perevich M et al (2009) Outcome of a randomized, double-blind, placebo controlled trial of botulinum A toxin for refractory overactive bladder. J Urol 181:2608–2615

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Fu WJ, Zhang X, Yang Y et al (2010) Comparison of 2-microm continuous wave laser vaporesection of the prostate and transurethral resection of the prostate: a prospective nonrandomized trial with 1-year follow-up. Urology 75:194–199

    Article  PubMed  Google Scholar 

  44. Gallucci M, Puppo P, Perachino M et al (1998) Transurethral electrovaporization of the prostate vs. transurethral resection. Results of a multicentric, randomized clinical study on 150 patients. Eur Urol 33:359–364

    Article  CAS  PubMed  Google Scholar 

  45. Gemeinsamer Bundesausschuss ‚G-BA‘ (2010) Nichtmedikamentöse lokale Verfahren zur Behandlung des benignen Prostatasyndroms. Abschlussbericht. G-BA, Berlin

  46. Gesenberg A, Sintermann R (1998) Management of benign prostatic hyperplasia in high risk patients: long-term experience with the Memotherm stent. J Urol 160:72–76

    Article  CAS  PubMed  Google Scholar 

  47. Ghalayini IF, Al-Ghazo MA, Pickard RS (2005) A prospective randomized trial comparing transurethral prostatic resection and clean intermittent self-catheterization in men with chronic urinary retention. BJU Int 96:93–97

    Article  PubMed  Google Scholar 

  48. Gill HS, Kabalin JN (1993) Urodynamic evaluation of patients in a randomized study of transurethral resection versus laser prostatectomy: pre-operative and one year follow-up. Neurourol Urodyn 12:372

    Google Scholar 

  49. Gilling PJ, Cass CB, Malcolm A et al (1998) Holmium laser resection of the prostate versus neodymium:yttrium-aluminum-garnet visual laser ablation of the prostate: a randomized prospective comparison of two techniques for laser prostatectomy. Urology 51:573–577

    Article  CAS  PubMed  Google Scholar 

  50. Gilling PJ, Kennett KM, Fraundorfer MR (2000) Holmium laser resection v transurethral resection of the prostate: results of a randomized trial with 2 years of follow-up. J Endourol 14:757–760

    Article  CAS  PubMed  Google Scholar 

  51. Gilling PJ, Mackey M, Cresswell M et al (1999) Holmium laser versus transurethral resection of the prostate: a randomized prospective trial with 1-year followup. J Urol 162:1640–1644

    Article  CAS  PubMed  Google Scholar 

  52. Gilling PJ, Wilson LC, King CJ et al (2012) Long-term results of a randomized trial comparing holmium laser enucleation of the prostate and transurethral resection of the prostate: results at 7 years. BJU Int 109:408–411

    Article  PubMed  Google Scholar 

  53. Gotoh M, Yoshikawa Y, Kondo AS et al (1999) Prognostic value of pressure-flow study in surgical treatment of benign prostatic obstruction. World J Urol 17:274–278

    Article  CAS  PubMed  Google Scholar 

  54. Gratzke C, Schlenker B, Seitz M et al (2007) Complications and early postoperative outcome after open prostatectomy in patients with benign prostatic enlargement: results of a prospective multicenter study. J Urol 177:1419–1422

    Article  PubMed  Google Scholar 

  55. Guazzoni G, Bergamaschi F, Montorsi F et al (1993) Prostatic UroLume Wallstent for benign prostatic hyperplasia patients at poor operative risk: clinical, uroflowmetric and ultrasonographic patterns. J Urol 150:1641–1646 (discussion 1646–1647)

    CAS  PubMed  Google Scholar 

  56. Guazzoni G, Montorsi F, Coulange C et al (1994) A modified prostatic UroLume Wallstent for healthy patients with symptomatic benign prostatic hyperplasia: a European Multicenter Study. Urology 44:364–370

    Article  CAS  PubMed  Google Scholar 

  57. Gupta N, Sivaramakrishna, Kumar R et al (2006) Comparison of standard transurethral resection, transurethral vapour resection and holmium laser enucleation of the prostate for managing benign prostatic hyperplasia of > 40 g. BJU Int 97:85–89

    Article  PubMed  Google Scholar 

  58. Hamann MF, Naumann CM, Seif C et al (2008) Functional outcome following photoselective vaporisation of the prostate (PVP): urodynamic findings within 12 months follow-up. Eur Urol 54:902–907

    Article  PubMed  Google Scholar 

  59. Hamidi Madani A, Enshaei A, Heidarzadeh A et al (2013) Transurethral intraprostatic Botulinum toxin-A injection: a novel treatment for BPH refractory to current medical therapy in poor surgical candidates. World J Urol 31:235–239

    Article  CAS  Google Scholar 

  60. Harbour R, Miller J (2001) A new system for grading recommendations in evidence based guidelines. BMJ 323:334–336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Hauser S, Rogenhofer S, Ellinger J et al (2012) Thulium laser (Revolix) vapoenucleation of the prostate is a safe procedure in patients with an increased risk of hemorrhage. Urol Int 88:390–394

    Article  PubMed  Google Scholar 

  62. Hellstrom P, Lukkarinen O, Kontturi M (1986) Bladder neck incision or transurethral electroresection for the treatment of urinary obstruction caused by a small benign prostate? A randomized urodynamic study. Scand J Urol Nephrol 20:187–192

    Article  CAS  PubMed  Google Scholar 

  63. Hochreiter W, Hugonnet C, Studer UE (1999) Transurethral resection of the prostate with the Holmium contact laser. Progress in treatment of benign prostatic hypertrophy? Urologe A 38:156–161

    Article  CAS  PubMed  Google Scholar 

  64. Höfner K, Bach T, Berges R et al (2014) S2e Leitlinie, Therapie des Benignen Prostatasyndroms (BPS), Aktualisierung 2014. Arbeitskreis Benignes Prostatasyndrom (AK BPS) (Hrsg), Books on Demand, ISBN 978-3-95780-025-1

  65. Horasanli K, Silay MS, Altay B et al (2008) Photoselective potassium titanyl phosphate (KTP) laser vaporization versus transurethral resection of the prostate for prostates larger than 70 mL: a short-term prospective randomized trial. Urology 71:247–251

    Article  PubMed  Google Scholar 

  66. Horninger W, Janetschek G, Watson G et al (1997) Are contact laser, interstitial laser, and transurethral ultrasound-guided laser-induced prostatectomy superior to transurethral prostatectomy? Prostate 31:255–263

    Article  CAS  PubMed  Google Scholar 

  67. Huidobro C, Larson B, Mynderse S et al (2009) Characterizing Prostiva RF treatments of the prostate for BPH with gadolinium-enhanced MRI. ScientificWorldJournal 9:10–16

    Article  PubMed  Google Scholar 

  68. Hung CT, Lin AT, Chen KK et al (1995) The subjective assessment and pressure-flow study of outcome of surgical treatment for patients with prostatism and high voiding pressure. Zhonghua Yi Xue Za Zhi (Taipei) 56:186–191

    Google Scholar 

  69. Iori F, Franco G, Leonardo C et al (2008) Bipolar transurethral resection of prostate: clinical and urodynamic evaluation. Urology 71:252–255

    Article  PubMed  Google Scholar 

  70. Issa MM (2008) Technological advances in transurethral resection of the prostate: bipolar versus monopolar TURP. J Endourol 22:1587–1595

    Article  PubMed  Google Scholar 

  71. James MJ, Harriss DR, Ceccherini A et al (1995) A urodynamic study of laser ablation of the prostate and a comparison of techniques. Br J Urol 76:179–183

    Article  CAS  PubMed  Google Scholar 

  72. Jensen KM, Jorgensen JB, Mogensen P (1988) Urodynamics in prostatism. I. Prognostic value of uroflowmetry. Scand J Urol Nephrol 114 (Suppl):63–71

    CAS  Google Scholar 

  73. Jensen KM, Jorgensen TB, Mogensen P (1996) Long-term predictive role of urodynamics: an 8-year follow-up of prostatic surgery for lower urinary tract symptoms. Br J Urol 78:213–218

    Article  CAS  PubMed  Google Scholar 

  74. Johnson TMJ, Busby-Whitehead J, Ashford-Works C et al (1998) Promoting help-seeking behavior for urinary inconctince. J Appl Gerontol 17:419–441

    Article  Google Scholar 

  75. Jung P, Schäfer W, Jakse G (1995) Visual laser ablation of the prostate. Efficacy according to prostate size evaluated by urodynamics and compared to TUR. Neurourol Urodyn 14:570

    Google Scholar 

  76. Kabalin JN, Gill HS, Bite G et al (1995) Comparative study of laser versus electrocautery prostatic resection: 18-month followup with complex urodynamic assessment. J Urol 153:94–97

    Article  CAS  PubMed  Google Scholar 

  77. Kaplan SA, Chiou RK, Morton WJ et al (1995) Long-term experience utilizing a new balloon expandable prostatic endoprosthesis: the Titan stent. North American Titan Stent Study Group. Urology 45:234–240

    Article  CAS  PubMed  Google Scholar 

  78. Karaman MI, Kaya C, Ozturk M et al (2005) Comparison of transurethral vaporization using PlasmaKinetic energy and transurethral resection of prostate: 1-year follow-up. J Endourol 19:734–737

    Article  PubMed  Google Scholar 

  79. Kaya C, Ilktac A, Gokmen E et al (2007) The long-term results of transurethral vaporization of the prostate using plasmakinetic energy. BJU Int 99:845–848

    Article  PubMed  Google Scholar 

  80. Krambeck AE, Handa SE, Lingeman JE (2010) Holmium laser enucleation of the prostate for prostates larger than 175 grams. J Endourol 24:433–437

    Article  PubMed  Google Scholar 

  81. Kuntz RM (2006) Current role of lasers in the treatment of benign prostatic hyperplasia (BPH). Eur Urol 49:961–969

    Article  PubMed  Google Scholar 

  82. Kuntz RM, Ahyai S, Lehrich K et al (2004) Transurethral holmium laser enucleation of the prostate versus transurethral electrocautery resection of the prostate: a randomized prospective trial in 200 patients. J Urol 172:1012–1016

    Article  PubMed  Google Scholar 

  83. Kuntz RM, Lehrich K, Ahyai SA (2008) Holmium laser enucleation of the prostate versus open prostatectomy for prostates greater than 100 grams: 5-year follow-up results of a randomised clinical trial. Eur Urol 53:160–166

    Article  PubMed  Google Scholar 

  84. Kuo HC (2005) Prostate botulinum A toxin injection – an alternative treatment for benign prostatic obstruction in poor surgical candidates. Urology 65:670–674

    Article  PubMed  Google Scholar 

  85. Kuo HC, Liu HT (2009) Therapeutic effects of add-on botulinum toxin A on patients with large benign prostatic hyperplasia and unsatisfactory response to combined medical therapy. Scand J Urol Nephrol 43:206–211

    Article  CAS  PubMed  Google Scholar 

  86. Larsen EH, Dorflinger T, Gasser TC et al (1987) Transurethral incision versus transurethral resection of the prostate for the treatment of benign prostatic hypertrophy. A preliminary report. Scand J Urol Nephrol 104 (Suppl):83–86

    CAS  Google Scholar 

  87. Larson BT, Netto N, Huidobro C et al (2006) Intraprostatic injection of alcohol gel for the treatment of benign prostatic hyperplasia: preliminary clinical results. ScientificWorldJournal 6:2474–2480

    Article  PubMed  Google Scholar 

  88. Leonardi R (2009) Preliminary results on selective light vaporization with the side-firing 980 nm diode laser in benign prostatic hyperplasia: an ejaculation sparing technique. Prostate Cancer Prostatic Dis 12:277–280

    Article  CAS  PubMed  Google Scholar 

  89. Lourenco T, Armstrong N, N’Dow J et al (2008) Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargement. Health Technol Assess 12:iii (ix–x 1–146, 169–515)

    Article  CAS  PubMed  Google Scholar 

  90. Lourenco T, Pickard R, Vale L et al (2008) Minimally invasive treatments for benign prostatic enlargement: systematic review of randomised controlled trials. BMJ 337:1662

    Article  Google Scholar 

  91. Lourenco T, Shaw M, Fraser C et al (2010) The clinical effectiveness of transurethral incision of the prostate: a systematic review of randomised controlled trials. World J Urol 28:23–32

    Article  PubMed  Google Scholar 

  92. Lukacs B, Loeffler J, Bruyere F et al (2012) Photoselective vaporization of the prostate with greenlight 120-W laser compared with monopolar transurethral resection of the prostate: a multicenter randomized controlled trial. Eur Urol 61:1165–1173

    Article  PubMed  Google Scholar 

  93. Madersbacher S, Marberger M (1999) Is transurethral resection of the prostate still justified? BJU Int 83:227–237

    Article  CAS  PubMed  Google Scholar 

  94. Mamoulakis C, Trompetter M, Rosette J de la (2009) Bipolar transurethral resection of the prostate: the ‚golden standard‘ reclaims its leading position. Curr Opin Urol 19:26–32

    Article  PubMed  Google Scholar 

  95. Mamoulakis C, Ubbink DT, Rosette JJ de la (2009) Bipolar versus monopolar transurethral resection of the prostate: a systematic review and meta-analysis of randomized controlled trials. Eur Urol 56:798–809

    Article  PubMed  Google Scholar 

  96. Manieri C, Tubaro A, Trucchi A et al (1995) Urodynamic evaluation of high energy transurethral microwave thermotherapy (v. 2.5) in the treatment of BPH. Urodinamica 5:127

    Google Scholar 

  97. Marberger M, Chartier-Kastler E, Egerdie B et al (2013) A randomized double-blind placebo-controlled phase 2 dose-ranging study of onabotulinumtoxinA in men with benign prostatic hyperplasia. Eur Urol 63:496–503

    Article  CAS  PubMed  Google Scholar 

  98. Marchal C, Perez JE, Herrera B et al (2012) The use of Botulinum toxin in benign prostatic hyperplasia. Neurourol Urodyn 31:86–92

    Article  CAS  PubMed  Google Scholar 

  99. Matsuta Y, Ichioka K, Terada N et al (2003) Interstitial laser coagulation for benign prostatic hyperplasia: clinical results of the Indigo diode laser system. Hinyokika Kiyo 49:195–200

    PubMed  Google Scholar 

  100. Mattiasson A, Wagrell L, Schelin S et al (2007) Five-year follow-up of feedback microwave thermotherapy versus TURP for clinical BPH: a prospective randomized multicenter study. Urology 69:91–96

    Article  PubMed  Google Scholar 

  101. McVary KT, Roehrborn CG, Avins AL et al (2011) Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol 185:1793–1803

    Article  PubMed  Google Scholar 

  102. Meyhoff HH, Gleason DM, Bottaccini MR (1989) The effects of transurethral resection on the urodynamics of prostatism. J Urol 142:785–789

    CAS  PubMed  Google Scholar 

  103. Meyhoff HH, Nordling J, Hald T (1984) Urodynamic evaluation of transurethral versus transvesical prostatectomy. A randomized study. Scand J Urol Nephrol 18:27–35

    Article  CAS  PubMed  Google Scholar 

  104. Minardi D, Garofalo F, Yehia M et al (2001) Pressure-flow studies in men with benign prostatic hypertrophy before and after treatment with transurethral needle ablation. Urol Int 66:89–93

    Article  CAS  PubMed  Google Scholar 

  105. Montorsi F, Naspro R, Salonia A et al (2004) Holmium laser enucleation versus transurethral resection of the prostate: results from a 2-center, prospective, randomized trial in patients with obstructive benign prostatic hyperplasia. J Urol 172:1926–1929

    Article  PubMed  Google Scholar 

  106. Moody JA, Lingeman JE (2001) Holmium laser enucleation for prostate adenoma greater than 100 gm.: comparison to open prostatectomy. J Urol 165:459–462

    Article  CAS  PubMed  Google Scholar 

  107. Mottet N, Anidjar M, Bourdon O et al (1999) Randomized comparison of transurethral electroresection and holmium: YAG laser vaporization for symptomatic benign prostatic hyperplasia. J Endourol 13:127–130

    Article  CAS  PubMed  Google Scholar 

  108. Naspro R, Suardi N, Salonia A et al (2006) Holmium laser enucleation of the prostate versus open prostatectomy for prostates > 70 g: 24-month follow-up. Eur Urol 50:563–568

    Article  PubMed  Google Scholar 

  109. Neal DE, Ramsden PD, Sharples L et al (1989) Outcome of elective prostatectomy (see comments). BMJ 299:762–767

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Netsch C, Bach T, Pohlmann L et al (2012) Comparison of 120–200 W 2 mum thulium:yttrium-aluminum-garnet vapoenucleation of the prostate. J Endourol 26:224–229

    Article  PubMed  Google Scholar 

  111. Netsch C, Pohlmann L, Herrmann TR et al (2012) 120-W 2-microm thulium:yttrium-aluminium-garnet vapoenucleation of the prostate: 12-month follow-up. BJU Int 110:96–101

    Article  PubMed  Google Scholar 

  112. Nielsen H (1988) Transurethral prostatomy versus transurethral prostatectomy in benign prostatic hypertrophy. a prospective randomised study. Br J Urol 61:435–438

    Article  CAS  PubMed  Google Scholar 

  113. Oelke M, Bachmann A, Descazeaud A et al (2012) Guidelines on management of male lower urinary tract symptoms (LUTS), incl. benign prostatic obstruction (BPO). In: Office Members of the European Association of Urology (EAU) Guidelines (Hrsg) EAU Guidelines, edition presented at the 27th EAU Annual Congress, Paris

  114. Oesterling JE, Kaplan SA, Epstein HB et al (1994) The North American experience with the UroLume endoprosthesis as a treatment for benign prostatic hyperplasia: long-term results. The North American UroLume Study Group. Urology 44:353–362

    Article  CAS  PubMed  Google Scholar 

  115. Ou R, You M, Tang P et al (2010) A randomized trial of transvesical prostatectomy versus transurethral resection of the prostate for prostate greater than 80 mL. Urology 76:958–961

    Article  PubMed  Google Scholar 

  116. Pereira-Correia JA, Moraes Sousa KD de, Santos JB et al (2012) GreenLight HPS120-W laser vaporization vs transurethral resection of the prostate (60 mL): a 2-year randomized double-blind prospective urodynamic investigation. BJU Int 110:1184–1189

    Article  PubMed  Google Scholar 

  117. Reich O, Bachmann A, Siebels M et al (2005) High power (80 W) potassium-titanyl-phosphate laser vaporization of the prostate in 66 high risk patients. J Urol 173:158–160

    Article  PubMed  Google Scholar 

  118. Reich O, Gratzke C, Bachmann A et al (2008) Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10,654 patients. J Urol 180:246–249

    Article  PubMed  Google Scholar 

  119. Reich O, Gratzke C, Stief CG (2006) Techniques and long-term results of surgical procedures for BPH. Eur Urol 49:970–978

    Article  PubMed  Google Scholar 

  120. Riehmann M, Knes JM, Heisey D et al (1995) Transurethral resection versus incision of the prostate: a randomized, prospective study. Urology 45:768–775

    Article  CAS  PubMed  Google Scholar 

  121. Rieken M, Ebinger Mundorff N, Bonkat G et al (2010) Complications of laser prostatectomy: a review of recent data. World J Urol 28:53–62

    Article  PubMed  Google Scholar 

  122. Rigatti L, Naspro R, Salonia A et al (2006) Urodynamics after TURP and HoLEP in urodynamically obstructed patients: are there any differences at 1 year of follow-up? Urology 67:1193–1198

    Article  PubMed  Google Scholar 

  123. Roehrborn CG, Burkhard FC, Bruskewitz RC et al (1999) The effects of transurethral needle ablation and resection of the prostate on pressure flow urodynamic parameters: analysis of the United States randomized study. J Urol 162:92–97

    Article  CAS  PubMed  Google Scholar 

  124. Roos NP, Wennberg JE, Malenka DJ et al (1989) Mortality and reoperation after open and transurethral resection of the prostate for benign prostatic hyperplasia. N Engl J Med 320:1120–1124

    Article  CAS  PubMed  Google Scholar 

  125. Rosario DJ, Woo H, Potts KL et al (1997) Safety and efficacy of transurethral needle ablation of the prostate for symptomatic outlet obstruction. Br J Urol 80:579–586

    Article  CAS  PubMed  Google Scholar 

  126. Rosette JJ de la, Wildt MJ de, Hofner K et al (1996) High energy thermotherapy in the treatment of benign prostatic hyperplasia: results of the European Benign Prostatic Hyperplasia Study Group. J Urol 156:97–102

    Article  PubMed  Google Scholar 

  127. Rosette JJ de la, Wildt MJ de, Hofner K et al (1996) Pressure-flow study analyses in patients treated with high energy thermotherapy. J Urol 156:1428–1433

    Article  PubMed  Google Scholar 

  128. Ruszat R, Seitz M, Wyler SF et al (2008) GreenLight laser vaporization of the prostate: single-center experience and long-term results after 500 procedures. Eur Urol 54:893–901

    Article  PubMed  Google Scholar 

  129. Ruszat R, Wyler S, Forster T et al (2007) Safety and effectiveness of photoselective vaporization of the prostate (PVP) in patients on ongoing oral anticoagulation. Eur Urol 51:1031–1041

    Article  CAS  PubMed  Google Scholar 

  130. Saemi AM, Folsom JB, Plante MK (2008) Injection therapy for prostatic disease: a renaissance concept. Indian J Urol 24:329–335

    Article  PubMed  PubMed Central  Google Scholar 

  131. Sahai A, Khan MS, Dasgupta P (2007) Efficacy of botulinum toxin-A for treating idiopathic detrusor overactivity: results from a single center, randomized, double-blind, placebo controlled trial. J Urol 177:2231–2236

    Article  CAS  PubMed  Google Scholar 

  132. Saporta L, Aridogan IA, Erlich N et al (1996) Objective and subjective comparison of transurethral resection, transurethral incision and balloon dilatation of the prostate. A prospective study. Eur Urol 29:439–445

    CAS  PubMed  Google Scholar 

  133. Seitz M, Sroka R, Gratzke C et al (2007) The diode laser: a novel side-firing approach for laser vaporisation of the human prostate – immediate efficacy and 1-year follow-up. Eur Urol 52:1717–1722

    Article  PubMed  Google Scholar 

  134. Seki N, Nomura H, Yamaguchi A et al (2008) Effects of photoselective vaporization of the prostate on urodynamics in patients with benign prostatic hyperplasia. J Urol 180:1024–1029

    Article  PubMed  Google Scholar 

  135. Shah DK, Paul EM, Badlani GH et al (2003) 11-year outcome analysis of endourethral prosthesis for the treatment of recurrent bulbar urethral stricture. J Urol 170:1255–1258

    Article  PubMed  Google Scholar 

  136. Sirls LT, Ganabathi K, Zimmern PE et al (1993) Transurethral incision of the prostate: an objective and subjective evaluation of long-term efficacy. J Urol 150:1615–1621

    CAS  PubMed  Google Scholar 

  137. Skolarikos A, Papachristou C, Athanasiadis G et al (2008) Eighteen-month results of a randomized prospective study comparing transurethral photoselective vaporization with transvesical open enucleation for prostatic adenomas greater than 80 cc. J Endourol 22:2333–2340

    Article  PubMed  Google Scholar 

  138. Soonawalla PF, Pardanani DS (1992) Transurethral incision versus transurethral resection of the prostate. A subjective and objective analysis. Br J Urol 70:174–177

    Article  CAS  PubMed  Google Scholar 

  139. Spangberg A, Teriö H, Ask P et al (1991) Pressure/flow studies preoperatively and postoperatively in patients with benign prostatic hypertrophy: estimation of the urethral pressure/flow relation and urethral elasticity. Neurourol Urodyn 10:139

    Article  Google Scholar 

  140. Steele GS, Sleep DJ (1997) Transurethral needle ablation of the prostate: a urodynamic based study with 2-year followup. J Urol 158:1834–1838

    Article  CAS  PubMed  Google Scholar 

  141. Szlauer R, Gotschl R, Razmaria A et al (2009) Endoscopic vaporesection of the prostate using the continuous-wave 2-microm thulium laser: outcome and demonstration of the surgical technique. Eur Urol 55:368–375

    Article  PubMed  Google Scholar 

  142. Tan A, Liao C, Mo Z et al (2007) Meta-analysis of holmium laser enucleation versus transurethral resection of the prostate for symptomatic prostatic obstruction. Br J Surg 94:1201–1208

    Article  CAS  PubMed  Google Scholar 

  143. Tan AH, Gilling PJ, Kennett KM et al (2003) A randomized trial comparing holmium laser enucleation of the prostate with transurethral resection of the prostate for the treatment of bladder outlet obstruction secondary to benign prostatic hyperplasia in large glands (40–200 grams). J Urol 170:1270–1274

    Article  CAS  PubMed  Google Scholar 

  144. Slaa E te, Mooibroek JJ, Reijke TM de et al (1996) Laser treatment of the prostate using the Urolase fiber: the Dutch experience. J Urol 156:420–425

    Article  Google Scholar 

  145. Thangasamy IA, Chalasani V, Bachmann A et al (2012) Photoselective vaporisation of the prostate using 80-W and 120-W laser versus transurethral resection of the prostate for benign prostatic hyperplasia: a systematic review with meta-analysis from 2002 to 2012. Eur Urol 62:315–323

    Article  PubMed  Google Scholar 

  146. Thomas AW, Cannon A, Bartlett E et al (2005) The natural history of lower urinary tract dysfunction in men: minimum 10-year urodynamic followup of transurethral resection of prostate for bladder outlet obstruction. J Urol 174:1887–1891

    Article  PubMed  Google Scholar 

  147. Tincello DG, Slack MC, Kenyon S et al (2011) Botulinum toxin-A for refractory detrusor overactivity in women: a 240 patient randomised placebo controlled trial. Eur Urol 10 (Suppl):191

    Article  Google Scholar 

  148. Tkocz M, Prajsner A (2002) Comparison of long-term results of transurethral incision of the prostate with transurethral resection of the prostate, in patients with benign prostatic hypertrophy. Neurourol Urodyn 21:112–116

    Article  PubMed  Google Scholar 

  149. Tubaro A, Carter S, Hind A et al (2001) A prospective study of the safety and efficacy of suprapubic transvesical prostatectomy in patients with benign prostatic hyperplasia. J Urol 166:172–176

    Article  CAS  PubMed  Google Scholar 

  150. Tuhkanen K, Heino A, Aaltomaa S et al (2003) Long-term results of contact laser versus transurethral resection of the prostate in the treatment of benign prostatic hyperplasia with small or moderately enlarged prostates. Scand J Urol Nephrol 37:487–493

    Article  PubMed  Google Scholar 

  151. Tuhkanen K, Heino A, Alaopas M (1999) Hybrid laser treatment compared with transurethral resection of the prostate for symptomatic bladder outlet obstruction caused by a large benign prostate: a prospective, randomized trial with a 6-month follow-up. BJU Int 84:805–809

    Article  CAS  PubMed  Google Scholar 

  152. Van Melick HH, Van Venrooij GE, Eckhardt MD et al (2002) A randomized controlled trial comparing transurethral resection of the prostate, contact laser prostatectomy and electrovaporization in men with benign prostatic hyperplasia: urodynamic effects. J Urol 168:1058–1062

    Article  Google Scholar 

  153. Varkarakis I, Kyriakakis Z, Delis A et al (2004) Long-term results of open transvesical prostatectomy from a contemporary series of patients. Urology 64:306–310

    Article  PubMed  Google Scholar 

  154. Varkarakis J, Bartsch G, Horninger W (2004) Long-term morbidity and mortality of transurethral prostatectomy: a 10-year follow-up. Prostate 58:248–251

    Article  PubMed  Google Scholar 

  155. Wagenlehner FM, Bescherer K, Wagenlehner C et al (2011) Urodynamic impact of acute urinary retention in patients with benign prostatic hyperplasia: a 2-year follow-up after transurethral resection of the prostate. Urol Int 86:73–79

    Article  PubMed  Google Scholar 

  156. Wagrell L, Schelin S, Nordling J et al (2002) Feedback microwave thermotherapy versus TURP for clinical BPH–a randomized controlled multicenter study. Urology 60:292–299

    Article  PubMed  Google Scholar 

  157. Westenberg A, Gilling P, Kennett K et al (2004) Holmium laser resection of the prostate versus transurethral resection of the prostate: results of a randomized trial with 4-year minimum long-term followup. J Urol 172:616–619

    Article  PubMed  Google Scholar 

  158. Wildt MJ de, Te Slaa E, Rosier PF et al (1995) Urodynamic results of laser treatment in patients with benign prostatic hyperplasia. Can outlet obstruction be relieved? J Urol 154:174–180

    Article  PubMed  Google Scholar 

  159. Wilson LC, Gilling PJ, Williams A et al (2006) A randomised trial comparing holmium laser enucleation versus transurethral resection in the treatment of prostates larger than 40 grams: results at 2 years. Eur Urol 50:569–573

    Article  PubMed  Google Scholar 

  160. Witjes WPJ, Robertson A, Rosier PF et al (1997) Urodynamic and clinical effects of noninvasive and minimally invasive treatments in elderly men with lower urinary tract symptoms stratified according to the grade of obstruction. Urology 50:55–61

    Article  CAS  PubMed  Google Scholar 

  161. Xia SJ, Zhuo J, Sun XW et al (2008) Thulium laser versus standard transurethral resection of the prostate: a randomized prospective trial. Eur Urol 53:382–389

    Article  PubMed  Google Scholar 

  162. Yang Q, Peters TJ, Donovan JL et al (2001) Transurethral incision compared with transurethral resection of the prostate for bladder outlet obstruction: a systematic review and meta-analysis of randomized controlled trials. J Urol 165:1526–1532

    Article  CAS  PubMed  Google Scholar 

  163. Zhang F, Shao Q, Herrmann TR et al (2012) Thulium laser versus holmium laser transurethral enucleation of the prostate: 18-month follow-up data of a single center. Urology 79:869–874

    Article  PubMed  Google Scholar 

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Einhaltung ethischer Richtlinien

Interessenkonflikt. T. Bschleipfer: Referent, Berater und/oder Studienteilnehmer für: Allergan, Astellas, Bayer Healthcare, Bionorica, GlaxoSmithKline, Pfizer, Serag Wiessner, Speciality European Pharma GmbH. T. Bach: Referent, Berater und/oder Studienteilnehmer für: Cook, Boston Scientific, GlaxoSmithKline, Richard Wolf, Rowa Pharma. R. Berges: Referent, Berater und/oder Studienteilnehmer für: Astellas, Ferring, GlaxoSmithKline, Neotract, Recordati. K. Dreikorn: Referent für: TAD-Pharma GmbH. C. Gratzke: Referent, Berater und/oder Studienteilnehmer für: American Medical Systems, Astellas, Bayer Healthcare, GlaxoSmithKline, Lilly, Madaus, Merck Sharp & Dome, Pfizer, Recordati, Rottapharm. S. Madersbacher: Referent, Berater und/oder Studienteilnehmer für: Allergan, Astellas, Austroplant, Bayer Healthcare, Boehringer, GlaxoSmithKline, Lilly, Madaus, Merck Sharp & Dome, Takeda, Pfizer, Sandoz. M.-S. Michel: Beteiligung bei onkologischen Arzneimittelstudien und Vortragshonorare ohne Relevanz für BPS. R. Muschter: Referent für: Amgen, American Medical Systems, Ferring, GlaxoSmithKline, Ibsen, Lilly, StarmedTec, Takeda. M. Oelke: Referent, Berater und/oder Studienteilnehmer für: Apogepha Arzneimittel GmbH, Allergan, Astellas, Bayer Healthcare, Biocompatibles, Ferring, GlaxoSmithKline, Lilly, Mundipharma, Pfizer, Recordati, Dr. Schwabe GmbH, TAD-Pharma GmbH. O. Reich: Referent und Berater für: American Medical Systems. C. Tschuschke: Referent, Berater, Studienteilnehmer und/oder Beteiligungen: Astellas, Ferring, Fresenius, GlaxoSmithKline, Lilly, Novartis, Dr. Pfleger GmbH, TAD-Pharma GmbH, Roche, Takeda. K. Höfner: Referent und Berater für: Aristo, Astellas, GlaxoSmithKline, Lilly.

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Authors and Affiliations

  1. Klinik für Urologie, Andrologie und Kinderurologie, Klinikum Weiden/Kliniken Nordoberpfalz AG, Söllnerstraße 16, 92637, Weiden, Deutschland

    T. Bschleipfer FEBU

  2. Abteilung für Urologie, Asklepios Klinikum Harburg, Hamburg, Deutschland

    T. Bach

  3. Gemeinschaftspraxis Urologische und Andrologische Diagnose und Therapie, PAN-Klinik, Köln, Deutschland

    R. Berges

  4. Urologische Praxis, Bremen, Deutschland

    K. Dreikorn

  5. Urologische Klinik und Poliklinik, Klinikum der LMU München, München, Deutschland

    C. Gratzke

  6. Abteilung für Urologie, Kaiser-Franz-Josef-Spital, Wien, Österreich

    S. Madersbacher

  7. Klinik für Urologie, Universitätsmedizin Mannheim, Mannheim, Deutschland

    M.-S. Michel

  8. Klinik für Urologie und Kinderurologie, Agaplesion Diakonieklinikum Rotenburg gemeinnützige GmbH, Rotenburg (Wümme), Deutschland

    R. Muschter

  9. Klinik für Urologie und Urologische Onkologie, Medizinische Hochschule Hannover, Hannover, Deutschland

    M. Oelke

  10. Klinik für Urologie, Klinikum Harlaching, Städtisches Klinikum München, München, Deutschland

    O. Reich

  11. Urologische Gemeinschaftspraxis, Münster, Deutschland

    C. Tschuschke

  12. Klinik für Urologie, Evangelisches Krankenhaus Oberhausen, Oberhausen, Deutschland

    K. Höfner

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  1. T. Bschleipfer FEBU
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Correspondence to T. Bschleipfer FEBU.

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Bschleipfer, T., Bach, T., Berges, R. et al. S2e-Leitlinie der Deutschen Urologen. Urologe 55, 195–207 (2016). https://doi.org/10.1007/s00120-015-3983-0

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