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Kindliche Blasenentwicklung

Eine aktuelle Standortbestimmung

Fetal bladder development

A current overview

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Zusammenfassung

Eine fetale Blasenanlage ist ab der 9. bis 10. Gestationswoche mikroskopisch erkennbar. Über den Hedgehog-Signalweg kommt es zur Induktion glatter Muskelzellentwicklung im umgebenden Mesenchym des Blasenlumens. Die Detrusordicke nimmt mit zunehmendem Gestationsalter linear und unabhängig vom fetalen Geschlecht zu. Die Darstellung neuester Erkenntnisse zur fetalen Blasenentwicklung möchte durch einen Einblick in frühe Regulationsvorgänge zum besseren Verständnis pathologischer Entwicklungsstörungen und ihrer klinischen Erscheinungsform am Harntrakt beitragen.

Abstract

Human fetal bladder development starts in the 9th to 10th week of gestation. Smooth muscle cell formation is induced by Hedgehog proteins and their signaling in the surrounding mesenchyma of the fetal bladder cavity. Bladder wall thickness increases significantly with advancing gestation, mediated by linear growth patterns irrespective of the related sex. lt is the aim of this artiole to address new insights into bladder development to enhance our knowledge about normal and pathological conditions that occur when developmental processes are disturbed.

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Notes

  1. Humane und Mausgene werden nach der Konvention durch groß- oder kleingeschriebene Abkürzungen kenntlich gemacht (Bsp: humanes „Sonic Hedgehog“ = SHH, bei der Maus = Shh, neutral hier verwendet als SHh).

  2. Die in den Abb. 2, Abb. 3, Abb. 4 gezeigten Schnittbildpräparate entstanden im Rahmen eines Studienaufenthalts (04.2005 bis 02.2006) der Autorin am Department für Kinderurologie der Klinik für Urologie, Medizin-Universität Innsbruck, Österreich, unter der Leitung von Univ. Prof. Dr. C. Radmayr in Zusammenarbeit mit dem Institut für Anatomie unter der Leitung von Univ. Prof. Dr. H. Fritsch (für nähere Details s. [6]).

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Authors and Affiliations

  1. Fellow of the European Academy of Pediatric Urology (FEAPU), Abteilung für Kinderurologie der Universität Regensburg, Klinik St. Hedwig , Steinmetzstraße 1–3, 93049, Regensburg, Deutschland

    I. Körner

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  1. I. Körner
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Correspondence to I. Körner.

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Körner, I. Kindliche Blasenentwicklung. Urologe 46, 1643–1646 (2007). https://doi.org/10.1007/s00120-007-1579-z

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  • DOI: https://doi.org/10.1007/s00120-007-1579-z

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