Zusammenfassung
Hintergrund
In den vergangenen Jahrzehnten hat sich die Ganzkörper-Magnetresonanztomographie (GK-MRT) für die Diagnose, das Staging und die Nachsorge onkologischer Erkrankungen sowie zum Screening bei Tumorprädispositionssyndromen (TPS), wie dem Li-Fraumeni-Syndrom, etabliert. Als umfassende Bildgebungsmethode ohne ionisierende Strahlung kann die GK-MRT beliebig häufig wiederholt eingesetzt werden und bietet aufgrund des ausgezeichneten Weichteilkontrasts und der hohen Auflösung eine frühzeitige, präzise Erkennung von Pathologien.
Methoden
Auf die technischen Voraussetzungen, einige Untersuchungsstrategien sowie die klinische Bedeutung typischer Befunde der GK-MRT-Bildgebung bei Patient:innen mit TPS wird in diesem Beitrag eingegangen.
Abstract
Background
In recent decades, whole-body magnetic resonance imaging (WB-MRI) has become established as the modality of choice for the diagnosis, staging, and follow-up of oncological diseases as well as for the screening of cancer predisposition syndromes, such as Li-Fraumeni syndrome.
Methods
As a comprehensive imaging modality without ionizing radiation, WB-MRI can be used repetitively and because of its excellent soft tissue contrast and high resolution provides early and precise detection of pathologies. This article discusses the technical requirements, some examination strategies and the clinical significance of typical findings of WB-MRI in patients with cancer predisposition syndromes.
Literatur
Ahlawat S, Blakeley JO, Langmead S et al (2020) Current status and recommendations for imaging in neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. Skelet Radiol 49:199–219
Anupindi SA, Bedoya MA, Lindell RB et al (2015) Diagnostic performance of whole-body MRI as a tool for cancer screening in children with genetic cancer-predisposing conditions. AJR Am J Roentgenol 205:400–408
Ballinger ML, Best A, Mai PL et al (2017) Baseline surveillance in Li-Fraumeni syndrome using whole-body magnetic resonance imaging: a meta-analysis. JAMA Oncol 3:1634–1639
Davis JT, Kwatra N, Schooler GR (2016) Pediatric whole-body MRI: a review of current imaging techniques and clinical applications. J Magn Reson Imaging 44:783–793
Dong SZ, Zhu M, Bulas D (2019) Techniques for minimizing sedation in pediatric MRI. J Magn Reson Imaging 50:1047–1054
Evans DGR, Salvador H, Chang VY et al (2017) Cancer and central nervous system tumor surveillance in pediatric neurofibromatosis 2 and related disorders. Clin Cancer Res 23:e54–e61
Evans DGR, Salvador H, Chang VY et al (2017) Cancer and central nervous system tumor surveillance in pediatric neurofibromatosis 1. Clin Cancer Res 23:e46–e53
Friedman DN, Hsu M, Moskowitz CS et al (2020) Whole-body magnetic resonance imaging as surveillance for subsequent malignancies in preadolescent, adolescent, and young adult survivors of germline retinoblastoma: an update. Pediatr Blood Cancer 67:e28389
Gatidis S, Guckel B, La Fougere C et al (2016) Simultaneous whole-body PET-MRI in pediatric oncology: more than just reducing radiation? Radiologe 56:622–630
Geiger J, Zeimpekis KG, Jung A et al (2021) Clinical application of ultrashort echo-time MRI for lung pathologies in children. Clin Radiol 76(9):708.e9–708.e17
Goo HW (2010) Whole-body MRI of neuroblastoma. Eur J Radiol 75(3):306–314. https://doi.org/10.1016/j.ejrad.2009.09.014
Grasparil AD 2nd, Gottumukkala RV, Greer MC et al (2020) Whole-body MRI surveillance of cancer predisposition syndromes: current best practice guidelines for use, performance, and interpretation. AJR Am J Roentgenol 215:1002–1011
Greer MC (2018) Imaging of cancer predisposition syndromes. Pediatr Radiol 48:1364–1375
Greer MC (2018) Whole-body magnetic resonance imaging: techniques and non-oncologic indications. Pediatr Radiol 48:1348–1363
Greer MC, Voss SD, States LJ (2017) Pediatric cancer predisposition imaging: focus on whole-body MRI. Clin Cancer Res 23:e6–e13
Guimaraes JB, da Cruz IAN, Ahlawat S et al (2021) The role of whole-body MRI in pediatric musculoskeletal oncology: current concepts and clinical applications. J Magn Reson Imaging. https://doi.org/10.1002/jmri.27787
Kamihara J, Bourdeaut F, Foulkes WD et al (2017) Retinoblastoma and neuroblastoma predisposition and surveillance. Clin Cancer Res 23:e98–e106
Kratz CP, Achatz MI, Brugieres L et al (2017) Cancer screening recommendations for individuals with Li-Fraumeni syndrome. Clin Cancer Res 23:e38–e45
Kumamoto T, Yamazaki F, Nakano Y et al (2021) Medical guidelines for Li-Fraumeni syndrome 2019, version 1.1. Int J Clin Oncol 26:2161–2178
Lemaire C, Moran GR, Swan H (2009) Impact of audio/visual systems on pediatric sedation in magnetic resonance imaging. J Magn Reson Imaging 30:649–655
Littooij AS, Kwee TC, De Keizer B et al (2015) Whole-body MRI-DWI for assessment of residual disease after completion of therapy in lymphoma: a prospective multicenter study. J Magn Reson Imaging 42:1646–1655
McGee K (2003) The role of a child life specialist in a pediatric radiology department. Pediatr Radiol 33:467–474
Müller-Horvat C, Plathow C, Ludescher B et al (2007) Generating statements at whole-body imaging with a workflow-optimized software tool—first experiences with multireader analysis. Rofo 179:721–727
Olsen OE (2008) Practical body MRI—a paediatric perspective. Eur J Radiol 68:299–308
Olthof SC, Reinert C, Nikolaou K et al (2021) Detection of lung lesions in breath-hold VIBE and free-breathing spiral VIBE MRI compared to CT. Insights Imaging 12:175
Rednam SP, Erez A, Druker H et al (2017) Von Hippel-Lindau and hereditary pheochromocytoma/paraganglioma syndromes: clinical features, genetics, and surveillance recommendations in childhood. Clin Cancer Res 23:e68–e75
Reinert CP, Schuhmann MU, Bender B et al (2019) Comprehensive anatomical and functional imaging in patients with type I neurofibromatosis using simultaneous FDG-PET/MRI. Eur J Nucl Med Mol Imaging 46:776–787
Saade-Lemus S, Degnan AJ, Acord MR et al (2019) Whole-body magnetic resonance imaging of pediatric cancer predisposition syndromes: special considerations, challenges and perspective. Pediatr Radiol 49:1506–1515
Schaefer J, Berthold L, Hahn G (2019) Ganzkörper-Magnetresonanztomografie im Kindes-und Jugendalter – S1-Leitlinie. Fortschr Röntgenstr 191:618–625
Schaefer JF, Kramer U (2011) Whole-body MRI in children and juveniles. Rofo 183:24–36
Schaefer JF, Schlemmer HP (2006) Total-body MR-imaging in oncology. Eur Radiol 16:2000–2015
Schäfer JF, Granata C, Von Kalle T et al (2020) Whole-body magnetic resonance imaging in pediatric oncology—recommendations by the Oncology Task Force of the ESPR. Pediatr Radiol 50:1162–1174
Törnqvist E, Månsson Å, Hallström I (2015) Children having magnetic resonance imaging: a preparatory storybook and audio/visual media are preferable to anesthesia or deep sedation. J Child Health Care 19:359–369
Villani A, Shore A, Wasserman JD et al (2016) Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study. Lancet Oncol 17:1295–1305
Zadig P, Von Brandis E, D’Angelo P et al (2022) Whole-body MRI in children aged 6–18 years. Reliability of identifying and grading high signal intensity changes within bone marrow. Pediatr Radiol 52:1272–1282
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
J. Herrmann, M. Esser, I. Brecht, I. Tsiflikas und J.F. Schäfer geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.
Additional information
QR-Code scannen & Beitrag online lesen
Rights and permissions
About this article
Cite this article
Herrmann, J., Esser, M., Brecht, I. et al. Ganzkörper-MRT bei Tumorprädispositionssyndromen. Radiologie 62, 1017–1025 (2022). https://doi.org/10.1007/s00117-022-01067-7
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00117-022-01067-7