Abstract
Antihormones are by definition antagonists of steroid hormone action. They interact with the ligand binding domains of steroid hormone receptors and competitively inhibit the action of the receptors by mechanisms that are not quite understood. In certain cases antihormones also exhibit agonistic activity especially in connection with certain naturally occurring receptor mutants. These observations together with findings of indiscriminate interaction of antihormones with several classes of steroid receptors have necessitated a search of more effective and reliable antihormones. Recent advances in the resolution of the crystal structure of the ligand binding domains of certain members of the steroid receptor family and identification of non-liganded activation of steroid receptors have produced considerable information that can be harnessed into a fruitful search for a new generation of antihormones.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 19 June 1997 / Accepted: 10 October 1997
Rights and permissions
About this article
Cite this article
Fuhrmann, U., Parczyk, K., Klotzbücher, M. et al. Recent developments in molecular action of antihormones. J Mol Med 76, 512–524 (1998). https://doi.org/10.1007/s001090050245
Issue Date:
DOI: https://doi.org/10.1007/s001090050245