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Akute Nierenschädigung: von Kreatinin zu KIM‑1?

Acute kidney injury: from creatinine to KIM‑1?

  • Schwerpunkt: Biomarker in der Akutmedizin
  • Published:
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Zusammenfassung

In der Diagnostik der akuten Nierenschädigung („acute kidney injury“ [AKI]) sind neben dem frühen Erfassen der AKI mehrere Probleme bzw. Fragen zu adressieren. Dazu zählen das Erkennen der Ursache, der Schwere (funktionell oder strukturell), der Prognose (Erholung oder Übergang in chronisches Nierenversagen) und des Verlaufs (Dialysepflichtigkeit oder nicht) sowie das Erfassen spezifischer Therapiemöglichkeiten bei AKI. Der vorliegende Beitrag gibt einen Überblick über etablierte und neue Biomarker der AKI sowie einen Ausblick auf zukünftige biomarkerassoziierte Modelle der AKI.

Abstract

In addition to the early detection of an acute kidney injury (AKI), several problems or questions have to be addressed. These include the identification of the etiology, the severity (functional or structural), the prognosis (recovery or transition to chronic renal failure), the course of the disease (dialysis or not), and the identification of specific treatment options for AKI. The following article provides an overview of established and new AKI biomarkers as well as an outlook on the potential of future biomarker-associated models of AKI.

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Authors and Affiliations

  1. Klinik für Nephrologie und Rheumatologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland

    M. Wallbach, B. Tampe, H. Dihazi &  M. J. Koziolek

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  1. M. Wallbach
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  2. B. Tampe
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  3. H. Dihazi
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  4. M. J. Koziolek
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Correspondence to M. J. Koziolek.

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Interessenkonflikt

B. Tampe und H. Dihazi geben an, dass kein Interessenkonflikt besteht. M.J. Koziolek gibt Vortragshonorare und Forschungsunterstützung von Novartis Pharma, Servier und CVRx an, M. Wallbach von CVRx.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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G. Hasenfuß, Göttingen

S. von Haehling, Göttingen

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Wallbach, M., Tampe, B., Dihazi, H. et al. Akute Nierenschädigung: von Kreatinin zu KIM‑1?. Internist 60, 578–586 (2019). https://doi.org/10.1007/s00108-019-0602-y

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  • DOI: https://doi.org/10.1007/s00108-019-0602-y

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