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Gen-Umwelt-Interaktion in Pathogenese und Prävention des Diabetes mellitus Typ 2

Gene-environment interactions in the pathogenesis and prevention of type 2 diabetes mellitus

  • Schwerpunkt: Diabetes mellitus
  • Published:
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Zusammenfassung

Diabetes mellitus Typ 2 ist eine chronisch-progressive Erkrankung, deren Grundlage eine genetisch und umweltbedingte Insulinsekretionsstörung der Betazellen des Pankreas und eine Insulinresistenz verschiedener Gewebe ist. Die Erkrankung an Diabetes mellitus Typ 2 hat weltweit epidemische Ausmaße angenommen. Durch Lebensstilintervention lässt sich die Manifestation des Diabetes mellitus Typ 2 verzögern und möglicherweise verhindern. Diese Übersicht beschreibt, wie genetische Faktoren, Umweltfaktoren und deren Interaktion das Diabetesrisiko beeinflussen und ebenso den Erfolg von Präventionsmaßnahmen bestimmen.

Abstract

Type 2 diabetes mellitus is a chronic progressive disease characterized by impaired insulin secretion of the beta cell and impaired insulin sensitivity of different tissues. The incidence of type 2 diabetes mellitus is increasing worldwide, and the disease has reached epidemic proportions. Lifestyle intervention programs are able to delay or possibly prevent the manifestation of type 2 diabetes mellitus. This review summarizes the genetic and environmental factors which influence the risk for type 2 diabetes and their interactions, and determine the success of prevention programs.

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  1. Abt. Innere Medizin IV, Universitätsklinikum Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Deutschland

    A. Fritsche, C. Thamer, N. Stefan & H.-U. Häring

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  1. A. Fritsche
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  2. C. Thamer
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  3. N. Stefan
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  4. H.-U. Häring
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Correspondence to A. Fritsche.

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Fritsche, A., Thamer, C., Stefan, N. et al. Gen-Umwelt-Interaktion in Pathogenese und Prävention des Diabetes mellitus Typ 2. Internist 48, 669–675 (2007). https://doi.org/10.1007/s00108-007-1874-1

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  • DOI: https://doi.org/10.1007/s00108-007-1874-1

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