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Sleep-disordered breathing children

Measurement of nasal nitric oxide and fractional exhaled nitric oxide

Kinder mit schlafbezogenen Atemstörungen

Messung des nasalen Stickstoffmonoxids und des fraktionierten exhalierten Stickstoffmonoxids

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Abstract

Objective

To assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with sleep-disordered breathing (SDB).

Methods

Enrolled in this study were 30 children with SDB and 15 healthy children. The nNO and FeNO concentrations were measured noninvasively using a NIOX MINO system (Aerocrine AB, Solna, Sweden). SPSS statistics 20.0 software (IBM SPSS statistics 20.0, Armonk, NY, USA) was used to analyze the data.

Results

The median (25th and 75th percentiles) nNO concentration of SDB children measured in parts per billion (ppb) was 111.0 (44.0; 349.0) ppb; FeNO concentration of SDB children was 12.0 (9.8; 14.0) ppb. The nNO concentration of healthy children was 52.0 (22.0; 139.0) ppb; FeNO concentration of healthy children was 12.0 (10.0; 16.0) ppb. Compared to healthy children, nNO concentration was significantly higher in children with SDB (Z = −2.215, P = 0.027). Correlation analysis showed that SDB children’s nNO concentration directly correlated with apnea–hypopnea index (AHI; r = 0.429, P = 0.018), and inversely correlated with nadir oxygen saturation (SaO2; r = −0.482, P = 0.007). No other polysomnographic parameters significantly correlated with nNO concentration.

Conclusion

Our data suggest that nNO concentration might be useful for diagnosis and evaluation of disease severity in SDB children. Furthermore, these results suggest that nNO concentration has a greater prognostic value than FeNO concentration.

Zusammenfassung

Ziel

Ziel war die Bestimmung der klinischen Bedeutung der nasalen Stickstoffmonoxid- („nasal nitric oxide“, nNO) und der fraktionierten exhalierten Stickstoffmonoxidkonzentration („fractional exhaled nitric oxide“, FeNO) bei Kindern mit schlafbezogenen Atemstörungen (SBAS).

Methoden

An der Studie nahmen 30 Kinder mit SBAS und 15 gesunde Kinder teil. Die nNO- und die FeNO-Konzentration wurden nichtinvasiv unter Einsatz des Systems NIOX MINO® (Fa. Aerocrine AB, Solna, Schweden) gemessen. Für die Auswertung der Daten wurden die Software SPSS Statistics 20.0 (IBM SPSS Statistics 20.0, Armonk/NY, USA) verwendet.

Ergebnisse

Die nNO-Konzentration der Kinder mit SBAS lag bei 111,0 (44,0; 349,0) ppb („parts per billion“, 10-9) im Median (25. und 75. Perzentile). Die FeNO-Konzentration der Kinder mit SBAS betrug 12,0 (9,8; 14,0) ppb. Dagegen lag die nNO-Konzentration der gesunden Kinder bei 52,0 (22,0; 139,0) ppb. Die FeNO-Konzentration der gesunden Kinder betrug 12,0 (10,0; 16,0) ppb. Im Vergleich zu gesunden Kindern war die nNO-Konzentration bei Kindern mit SBAS signifikant höher (z =−2,215; p =0,027). Die Korrelationsanalyse zeigte, dass die nNO-Konzentration der Kinder mit SBAS direkt mit dem Apnoe-Hypopnoe-Index (AHI) korreliert war (r =0,429; p =0,018), eine umgekehrte Korrelation bestand mit dem Nadir der arteriellen Sauerstoffsättigung (SaO2; r =−0,482; p =0,007). Jedoch war die nNO-Konzentration nicht signifikant mit anderen polysomnographischen Parametern korreliert.

Schlussfolgerung

Den vorliegenden Daten zufolge ist die nNO-Konzentration möglicherweise nützlich für die Diagnosestellung und die Beurteilung des Schweregrads bei Kindern mit SBAS. Darüber hinaus ist nach den vorliegenden Ergebnissen die nNO-Konzentration dabei von höherer prognostischer Aussagekraft als die FeNO-Konzentration.

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Authors and Affiliations

  1. Guangdong Women and Children Hospital, 510000, Guangzhou, Guangdong, China

    Y. Huang, Y. Zou, F. Mai, X. Zhang, Y. Liu & X. Lin

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  1. Y. Huang
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  2. Y. Zou
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  3. F. Mai
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  4. X. Zhang
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  5. Y. Liu
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  6. X. Lin
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Correspondence to Y. Zou.

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Conflict of interest

Y. Huang, Y. Zou, F. Mai, X. Zhang, Y. Liu, and X. Lin state that there are no conflicts of interest.

All studies on humans described in the present manuscript were carried out with the approval of the responsible ethics committee and in accordance with national law and the Helsinki Declaration of 1975 (in its current, revised form). Informed consent was obtained from all patients included in studies.

Additional information

Redaktion

P.K. Plinkert, Heidelberg

B. Wollenberg, Lübeck

Yaping Huang and Yu Zou contributed equally to this manuscript.

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Huang, Y., Zou, Y., Mai, F. et al. Sleep-disordered breathing children. HNO 64, 169–174 (2016). https://doi.org/10.1007/s00106-016-0120-3

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  • DOI: https://doi.org/10.1007/s00106-016-0120-3

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