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Retinoide in der Dermatopharmakologie

Retinoids in dermatopharmacology

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Zusammenfassung

Hintergrund

Retinoide haben eine Vielzahl an wichtigen Funktionen wie Regulation von Zellproliferation und -differenzierung und spielen eine wichtige Rolle im Körper, nicht zuletzt für die Haut.

Fragestellung

Es erfolgt die Darstellung eines Überblicks über Einsatz, Wirk- sowie Nebenwirkungsspektren der pharmakologisch eingesetzten topischen und systemischen Retinoide.

Material und Methode

Es wurde eine Pubmed/Medline-Literaturrecherche insbesondere unter Berücksichtigung der aktuellen deutschsprachigen und englischsprachigen Literatur vorgenommen.

Ergebnisse

Die Gruppe der pharmakologisch eingesetzten Retinoide umfassen natürliche wie auch synthetisch hergestellte Vitamin-A-Derivate. Wegen ihren Eigenschaften, den Keratinisierungsprozess und die epitheliale Differenzierung der Haut sowie die Proliferation von benignen und malignen Hautzellen zu beeinflussen, fanden Retinoide eine breite Anwendung im Bereich der Dermatopharmakologie.

Schlussfolgerung

Retinoide sind effektive Medikamente mit weitem therapeutischem Spektrum und breiter klinischer Anwendung in der Dermatologie. Gründliche Kenntnisse über Nebenwirkungen und eine umfassende Aufklärung des Patienten sind im sicheren Umgang mit Retinoiden essenziell.

Abstract

Background

Retinoids are important in regulating cell proliferation and differentiation and play an important role in the body, including the skin.

Objectives

Our objective is to review the current medical literature regarding use, effects and side-effects of topical and systemic retinoids used for therapy.

Methods

Pubmed/Medline electronic database was searched for relevant German and English literature.

Results

The group of retinoids used for therapeutic purposes includes both naturally occurring and chemically synthesized vitamin A derivates. Because of their influence on keratinization and epithelial differentiation, as well on the proliferation of benign and malignant keratinocytes, retinoids have found a wide application in the field of dermatopharmacology.

Conclusion

Retinoids are among the most efficacious drugs used in the treatment of dermatological disorders and have a wide range of biological effects. Thorough knowledge about side-effects and comprehensive information for the patient are essential for safe treatment with retinoids.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. P.M. Amann, H.F. Merk und J.M. Baron geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Aachen, Deutschland

    P.M. Amann, H.F. Merk & J.M. Baron

  2. Hautklinik, SLK-Klinikum Heilbronn, Am Gesundbrunnen 20–26, 74078, Heilbronn, Deutschland

    P.M. Amann

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  1. P.M. Amann
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  2. H.F. Merk
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Correspondence to P.M. Amann.

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Amann, P., Merk, H. & Baron, J. Retinoide in der Dermatopharmakologie. Hautarzt 65, 98–105 (2014). https://doi.org/10.1007/s00105-013-2649-3

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