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Fraktionierte Photothermolyse

Eine neue therapeutische Option in der Behandlung des Melasma?

Fractional photothermolysis

A new option for treating melasma?

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Zusammenfassung

Das Melasma/Chloasma ist eine häufige erworbene Hyperpigmentierung im Gesichts- und Halsbereich, die außerordentlich schwer zu behandeln ist. In den letzten Jahren wurden bei Patienten, die auf die herkömmlichen Externa nicht ansprechen, auch Laser eingesetzt. Allerdings konnte bisher kein akzeptabler Kompromiss zwischen Effekt und Nebenwirkungen gefunden werden. Diesbezüglich könnte die fraktionierte Photothermolyse Abhilfe versprechen, da sie bei einer Reihe von Indikationen die Effektivität der ablativen und das geringe Nebenwirkungsprofil der nichtablativen Laserverfahren auf sich vereinigt. Bislang gibt es jedoch noch sehr wenige Studien, die den Effekt dieser innovativen Technik beim Melasma untersuchen, sodass ihre Wertigkeit derzeit nicht endgültig beurteilt werden kann. Nach dem gegenwärtigen Stand der Literatur und den eigenen Erfahrungen gibt es zweifellos ein Potenzial, das in systematischen Untersuchungen weiter eruiert werden sollte. Der Euphorie – die in einigen publizierten Arbeiten zu erkennen ist – können wir uns allerdings zum jetzigen Zeitpunkt noch nicht anschließen.

Abstract

Melasma or chloasma is a common acquired hypermelanosis of the face and neck that is notoriously difficult to treat. Laser treatment has been employed in patients who do not respond to conventional topical agents but has failed to achieve an acceptable compromise between efficacy and side effects. Fractional photothermolysis (FP) combines the efficacy of ablative and the tolerability of non-ablative laser treatment in some skin conditions. There are few studies on using FP in melasma and its value cannot be estimated presently. Review of the literature and the authors’ own experience show a definite potential which should be further investigated in systematic studies, but we cannot at this point subscribe to the euphoria expressed in some publications.

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Notes

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  1. Laserklinik Karlsruhe, Kaiserstraße 104, 76133, Karlsruhe, Deutschland

    S. Karsai & C. Raulin

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Karsai, S., Raulin, C. Fraktionierte Photothermolyse. Hautarzt 59, 92–100 (2008). https://doi.org/10.1007/s00105-007-1458-y

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