Zusammenfassung
Die Therapie der atopischen Dermatitis erfordert eine regelmäßige ärztliche Beratung, um eine dem Hautzustand entsprechend optimale Behandlung zu ermöglichen. Der Verlauf dieser chronisch-rezidivierenden Hauterkrankung unterliegt dem Einfluss multipler Triggerfaktoren, die im Behandlungskonzept zu berücksichtigen sind. Die Basis der symptomatischen Therapie ist die konsequente stadiengerechte Lokaltherapie, die pflegende und antiseptische Externa sowie topische Steroide und neuerdings auch topische Immunmodulatoren umfasst. Bei häufig rezidivierenden akuten Exazerbationen stehen mit phototherapeutischen Interventionen und immunsuppressiven Verfahren weitere Therapieoptionen zu Verfügung, die zu einer langfristigen Stabilisierung eingesetzt werden können. Daten experimenteller Therapieversuche geben Einblick in zukünftige Behandlungsansätze.
Abstract
The optimal treatment of atopic dermatitis requires regular medical supervision. The course of this chronic skin disease is influenced by multiple triggers which are relevant for the treatment. The mainstays of topical therapy include regular use of emollients coupled with antimicrobial substances, corticosteroids and immune modulators as required. Ultraviolet radiation and immunosuppressive regimens represent further options for the treatment of severe exacerbations and may lead to long term improvement. Data from experimental studies provide insight into possible future treatment methods.
Literatur
Abeck D, Brockow K, Fesq H, Ring J (1999) Behandlung des akut exazerbierten atopischen Ekzems mit fett-feuchten Verbänden und topischem Chlorhexidin. Hautarzt 50:418–421
Abeck D, Schmidt T, Fesq H et al. (2000) Long-term efficacy of medium-dose UVA1 phototherapie in atopic dermatitis. J Am Acad Dermatol 42:254–257
Abeck D, Mempel M(1998) S. aureus colonization in atopic dermatitis and its therapeutic implications. Br J Dermatol 139 [Suppl 53]:13–16
Ainley-Walker PF, Patel L, David TJ (1998) Side to side comparison of topical treatment in atopic dermatitis. Arch Dis Child 79:149–152
Berth-Jones J, Graham-Brown RAC, Marks R et al. (1997) Long-term efficacy and safety of cyclosporine in severe adult atopic dermatitis. Br J Dermatol 136:76–81
Berth-Jones J, Takwale A, Tan E et al. (2002) Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial. Br J Dermatol 147:324–330
Bhargava HN, Leonhard PA (1996) Triclosan: application and safety. Am J Infect Contr 24:209–218
Breuer K, Häussler S, Kapp A, Werfel T (2002) Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol 147:55–61
Broberg A, Faergelmann (1995) Topical antimycotic treatment of atopic dermatitis in the head/neck area. Acta Derm Venereol 75:46–49
Capella GL, Grigerio E, Altomare G (2001) A randomized trial of leukotriene receptor antagonist motelukast in moderate-to-severe atopic dermatitis of adults. Eur J Dermatol 11:209–213
de Kort WJ, van Weelden H (2000) Bath psoralen-ultraviolet A therapy in atopic eczema. J Eur Acad Dermatol Venereol 14:172–174
Der-Petrossian M, Seeber A, Hönigsmann H, Tanew A (2000) Half-side comparison study on the efficiacy of 8-methoxypsoralen bath-PUVA versus narrow-band ultraviolet B phototherapy in patients with severe chronic atopic dermatitis. Br J Dermatol 142:39–43
Diepgen TL on behalf of the ETAC Study Group (2002) Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trail) over 18 months. Pediatr Allergy Immunol 13:278–286
Diepgen et al. (2003) Neurodermitis-Schulung. Hautarzt (dieses Themenheft)
Dittmar HC, Pflieger D, Schöpf E, Simon JC (2001) UVA1-Phototherapie. Hautarzt 52:423–427
Drake LA, Ceilly RI, Cornelison RL et al. (1992) Guidelines of care for atopic dermatitis. J Am Acad Dermatol 26:485–488
Dutz JP, Ho VC (1998) Immunosuppressive agents in dermatology. Dermatol Therapy 16:235–251
Ellison JA, Patel L, Ray DW et al. (2000) Hypothalamic-pituitary-adrenal function and glucocorticoid sensitivity in atopic dermatitis. Pediatrics 105:794–799
Fischer J, Ring J, Abeck D (2003) Spektrum der Provokationsfaktoren beim atopischen Ekzem und Möglichkeiten ihrer wirkungsvollen Reduktion beziehungsweise Elimination. Hautarzt (dieses Themenheft)
Fung AYP, Look PCN, Chong LY et al. (1999) A controlled trial of traditional herbal medicine in chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 38:387–392
Furue M, Terao H, Rikihisa W et al. (2003) Clinical dose and adverse effects of topical steroids in daily management of atopic dermatitis. Br J Dermatol 148:128–133
Gehring W, Forssman T, Jost G, Gloor M (1996) Die keimreduzierende Wirkung von Erythromycin und Triclosan bei der atopischen Dermatitis. Akt Dermatol 22:28–31
Gloor M, Becker A, Wasik B, Kniehl E (2002) Triclosan, ein dermatologisches Lokaltherapeutikum. Hautarzt 53:724–729
Grabbe J, Welker P, Humke S et al. (1996) High-dose UVA1, but not UVA-UVB therapy decreases IgE binding cells in lesional skin of patients with atopic eczema. J Invest Dermatol 107:419–422
Griffiths CE, van Leent EJ, Gilbert M, Traulsen J (2002) Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis. Br J Dermatol 147:299–307
Grundmann-Kollmann M, Podda M, Ochsendorf F et al. (2001) Mycophenolate mofetil is effective in the treatment of atopic dermatitis. Arch Dermatol 137:870–873
Harper J, Green A, Scott G et al. (2001) First experience of topical SDZ ASM 981 in children with atopic dermatitis. Br J Dermatol 144:781–787
Harper JI, Berth-Jones J, Camp RDR et al. (2001) Cyclosporine for atopic dermatitis in children. Dermatology 203:3–6
Isolauri E, Arvola T, Sütas Y et al. (2000) Probiotics in the management of atopic eczema. Clin Exp Allergy 30:1604–1610
Jolles S (2002) A review of high-dose intravenous immunoglobulin treatment for atopic dermatitis. Clin Exp Dermatol 27:3–7
Kägi MK (1998) Aktuelle Empfehlungen für die Therapie des atopischen Ekzems. Allergologie 21:332–337
Krutman J (1999) Therapeutic photomedicine: phototherapy In: Freedberg IM, Eison AZ, Wolff K et al. (eds) Fitzpatrick's dermatology in general medicine, 5th edn. Mc Graw-Hill, New York, pp 2870–2879
Krutmann J (2000) Phototherapy for atopic dermatitis. Clin Exp Dermatol 25:552–558
Krutmann J, Diepgen TL, Luger TA et al. (1998) High-dose UVA1 therapy für atopic dermatitis: results of a multicenter trial. J Am Acad Dermatol 38:589–593
Leroy BP, Boden G, Lachapelle JM et al. (1997) A novel therapy for atopic dermatitis with allergen-antibody complexes: a double-blind, placebo-controlled study. J Am Acad Dermatol 28:232–239
Liu J (1993) FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. Immunol Today 14:290–295
Mastrandea F (2001) Immunotherapy in atopic dermatitis. Expert Opin Investig Drugs 10:49–63
Meggitt SJ, Reynolds NJ (2001) Azathioprine for atopic dermatitis. Clin Exp Dermatol 26:369–375
Meurer M, Wozel G (2003) Behandlung des atopischen Ekzems bei Erwachsenen mit topischen Calcineurininhibtoren. Hautarzt 54:432–439
Neuber K, Schwartz I, Itschert G, Dieck AT (2000) Treatment of atopic eczema with oral mycophenolate mofetil. Br J Dermatol 143:385–391
Niedner R (2003) Topische Kortikoide versus Calcineurinantagonisten. Hautarzt 54:338–341
Nilsson EJ, Henning CG, Magnusson J (1992) Topical corticosteroids and staphylococcus aureus in atopic dermatitis. J Am Acad Dermatol 27:29–34
Oishi Y, Fu ZW, Ohnuki Y et al. (2002) Molecular basis of the alteration in skin collagen metabolism in response to in vivo dexamethasone treatment: effects on the synthesis of collagen type I and III, collagenase, and tissue inhibitors of metalloproteinases. Br J Dermatol 147:859–868
Patel L, Clayton PE, Addison GM et al. (1995) Adrenal function following topical steroid treatment in children with atopic dermatitis. Br J Dermatol 132:950–955
Peeters KA, Mascini EM, Blok HE, Sanders CJ (2002) Increase of resistance to fusidic acid among staphylococcus aureus isolates from patients admitted with atopic dermatitis. Ned Tijdschr Geneeskd 146:2100–2101
Pei AYS, Chan HHL, Leung TF (2001) Montelukast in the treatment of children with moderate-to-severe atopic dermatitis: a pilot study. Pediatr Allergy Immunol 12:154–158
Pittler MH, Armstrong NC, Cox A et al. (2003) Randomized, double-blind, placebo-controlled trial of autologous blood therapy for atopic dermatitis. Br J Dermatol 148:307–313
Pournaras CC, Lübbe J, Saurat JH (2001) Staphylococcal colonization in atopic dermatitis treatment with topical tacrolimus (FK506). J Invest Dermatol 116:480–481
Queille-Roussel C, Paul C, Duteil L et al. (2001) The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. Br J Dermatol 144:507–513
Raap U, Jäger B, Werfel T, Schmid-Ott G (2003) Stress und Neurodermitis (dieses Themenheft)
Reider N, Zloczower M, Fritsch P, Kofler H (1998) Antihistaminika Teil II. Hautarzt 49:734–742
Reitamo S, Wollenberg A, Schoepf E et al. (2000) Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. Arch Dermatol 136:999–1006
Remitz A, Kyllönen H, Granlund H, Reitamo S (2001) Tacrolimus ointment reduces the staphylococcal colonization of atopic dermatitis lesions. J Allergy Clin Immunol 107:391–392
Richter H, Billmann-Eberwein C, Grewe M et al. (1998) Successfull monotherapy of severe and intractable atopic dermatitis by photopheresis. J Am Acad Dermatol 38:585–588
Rosenfeldt V, Benfeldt E, Dam Nielsen S et al. (2003) Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol 111:389–395
Schäfer T, Breuer K (2003) Epidemiologie von Nahrungsmittelallergien. Hautarzt 54:121–129
Schempp CM, Effinger T, Czech W et al. (1997) Charakterisierung von Non-Respondern bei der hochdosierten UVA1-Therapie der akut exazerbierten atopischen Dermatitis. Hautarzt 48:94–99
Sheehan MP, Atherton DJ (1994) One-year follow up of children treated with chinese medicinal herbs for atopic aczema. Br J Dermatol 130:488–493
Sporik R, Kemp AS (1997) Topical triclosan treatment of atopic dermatitis. J Allergy Clin Immunol 99:861
Stalder JF, Fleury M, Sourisse M et al. (1994) Local steroid therapy and bacterial skin flora in atopic dermatitis Br J Dermatol 131:536–540
Stockfleth E, Ulrich C, Meyer T, Christophers E (2002) Epithelial malignancies in organ transplant patients: clinical presentation and new methods of treatment. Recent Results Cancer Res 160:251–258
Tan BB, Lear JT, Gwakrdger DJ, English JSC (1997) Azathioprine in dermatology: a survey of current practice in the U.K. Br J Dermatol 136:351–355
von Kobyletzki G, Freitag M, Herde M et al. (1999) Phototherapie bei schwerer atopischer Dermatitis. Hautarzt 50:27–33
Warner JO (2001) A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18' posttreatment follow-up. J Allergy Clin Immunol 108:929–937
Werfel T, Aberer W, Bieber T et al. (im Druck) Atopische Dermatitis. J Am Acad Dermatol
Wilkinson JD (1998) Fusidic acid in dermatology. Br J Dermatol 139:37–40
Willeam REA, Gibson AG, Aitchison TC et al. (1990) Assessment of a contact-plate sampling technique and subsequent quantitative bacterial studies in atopic dermatitis. Br J Dermatol 123:493–501
Wolthers OD, Heuck C, Ternowitz T et al. (1996) Insulin-like growth factor axis, bone and collagen turnover in children with atopic dermatitis treated with topical glucocorticosteroids. Dermatology 192:337–342
Yanase MDJ, David-Bajaar K (2001) The leukotriene antagonist montelukast as a therapeutic agent for atopic dermatitis. J Am Acad Dermatol 44:89–93
Yoshimura M, Namura S, Akamatsu H, Horio T (1996) Antimicrobial effects of phototherapy and photochemotherapy in vivo and in vitro. Br J Dermatol 135:528–532
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Heratizadeh, A., Breuer, K., Kapp, A. et al. Symptomatische Therapie der atopischen Dermatitis. Hautarzt 54, 937–945 (2003). https://doi.org/10.1007/s00105-003-0605-3
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DOI: https://doi.org/10.1007/s00105-003-0605-3