Skip to main content
Log in

Symptomatische Therapie der atopischen Dermatitis

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

Die Therapie der atopischen Dermatitis erfordert eine regelmäßige ärztliche Beratung, um eine dem Hautzustand entsprechend optimale Behandlung zu ermöglichen. Der Verlauf dieser chronisch-rezidivierenden Hauterkrankung unterliegt dem Einfluss multipler Triggerfaktoren, die im Behandlungskonzept zu berücksichtigen sind. Die Basis der symptomatischen Therapie ist die konsequente stadiengerechte Lokaltherapie, die pflegende und antiseptische Externa sowie topische Steroide und neuerdings auch topische Immunmodulatoren umfasst. Bei häufig rezidivierenden akuten Exazerbationen stehen mit phototherapeutischen Interventionen und immunsuppressiven Verfahren weitere Therapieoptionen zu Verfügung, die zu einer langfristigen Stabilisierung eingesetzt werden können. Daten experimenteller Therapieversuche geben Einblick in zukünftige Behandlungsansätze.

Abstract

The optimal treatment of atopic dermatitis requires regular medical supervision. The course of this chronic skin disease is influenced by multiple triggers which are relevant for the treatment. The mainstays of topical therapy include regular use of emollients coupled with antimicrobial substances, corticosteroids and immune modulators as required. Ultraviolet radiation and immunosuppressive regimens represent further options for the treatment of severe exacerbations and may lead to long term improvement. Data from experimental studies provide insight into possible future treatment methods.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Abeck D, Brockow K, Fesq H, Ring J (1999) Behandlung des akut exazerbierten atopischen Ekzems mit fett-feuchten Verbänden und topischem Chlorhexidin. Hautarzt 50:418–421

    Article  CAS  PubMed  Google Scholar 

  2. Abeck D, Schmidt T, Fesq H et al. (2000) Long-term efficacy of medium-dose UVA1 phototherapie in atopic dermatitis. J Am Acad Dermatol 42:254–257

    CAS  PubMed  Google Scholar 

  3. Abeck D, Mempel M(1998) S. aureus colonization in atopic dermatitis and its therapeutic implications. Br J Dermatol 139 [Suppl 53]:13–16

  4. Ainley-Walker PF, Patel L, David TJ (1998) Side to side comparison of topical treatment in atopic dermatitis. Arch Dis Child 79:149–152

    CAS  PubMed  Google Scholar 

  5. Berth-Jones J, Graham-Brown RAC, Marks R et al. (1997) Long-term efficacy and safety of cyclosporine in severe adult atopic dermatitis. Br J Dermatol 136:76–81

    CAS  PubMed  Google Scholar 

  6. Berth-Jones J, Takwale A, Tan E et al. (2002) Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial. Br J Dermatol 147:324–330

    Article  CAS  PubMed  Google Scholar 

  7. Bhargava HN, Leonhard PA (1996) Triclosan: application and safety. Am J Infect Contr 24:209–218

    PubMed  Google Scholar 

  8. Breuer K, Häussler S, Kapp A, Werfel T (2002) Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol 147:55–61

    Article  CAS  PubMed  Google Scholar 

  9. Broberg A, Faergelmann (1995) Topical antimycotic treatment of atopic dermatitis in the head/neck area. Acta Derm Venereol 75:46–49

    CAS  PubMed  Google Scholar 

  10. Capella GL, Grigerio E, Altomare G (2001) A randomized trial of leukotriene receptor antagonist motelukast in moderate-to-severe atopic dermatitis of adults. Eur J Dermatol 11:209–213

    CAS  PubMed  Google Scholar 

  11. de Kort WJ, van Weelden H (2000) Bath psoralen-ultraviolet A therapy in atopic eczema. J Eur Acad Dermatol Venereol 14:172–174

    Article  PubMed  Google Scholar 

  12. Der-Petrossian M, Seeber A, Hönigsmann H, Tanew A (2000) Half-side comparison study on the efficiacy of 8-methoxypsoralen bath-PUVA versus narrow-band ultraviolet B phototherapy in patients with severe chronic atopic dermatitis. Br J Dermatol 142:39–43

    Article  CAS  PubMed  Google Scholar 

  13. Diepgen TL on behalf of the ETAC Study Group (2002) Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trail) over 18 months. Pediatr Allergy Immunol 13:278–286

    Article  PubMed  Google Scholar 

  14. Diepgen et al. (2003) Neurodermitis-Schulung. Hautarzt (dieses Themenheft)

  15. Dittmar HC, Pflieger D, Schöpf E, Simon JC (2001) UVA1-Phototherapie. Hautarzt 52:423–427

    Article  CAS  PubMed  Google Scholar 

  16. Drake LA, Ceilly RI, Cornelison RL et al. (1992) Guidelines of care for atopic dermatitis. J Am Acad Dermatol 26:485–488

    PubMed  Google Scholar 

  17. Dutz JP, Ho VC (1998) Immunosuppressive agents in dermatology. Dermatol Therapy 16:235–251

    CAS  Google Scholar 

  18. Ellison JA, Patel L, Ray DW et al. (2000) Hypothalamic-pituitary-adrenal function and glucocorticoid sensitivity in atopic dermatitis. Pediatrics 105:794–799

    CAS  PubMed  Google Scholar 

  19. Fischer J, Ring J, Abeck D (2003) Spektrum der Provokationsfaktoren beim atopischen Ekzem und Möglichkeiten ihrer wirkungsvollen Reduktion beziehungsweise Elimination. Hautarzt (dieses Themenheft)

  20. Fung AYP, Look PCN, Chong LY et al. (1999) A controlled trial of traditional herbal medicine in chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 38:387–392

    Article  CAS  PubMed  Google Scholar 

  21. Furue M, Terao H, Rikihisa W et al. (2003) Clinical dose and adverse effects of topical steroids in daily management of atopic dermatitis. Br J Dermatol 148:128–133

    Article  CAS  PubMed  Google Scholar 

  22. Gehring W, Forssman T, Jost G, Gloor M (1996) Die keimreduzierende Wirkung von Erythromycin und Triclosan bei der atopischen Dermatitis. Akt Dermatol 22:28–31

    Google Scholar 

  23. Gloor M, Becker A, Wasik B, Kniehl E (2002) Triclosan, ein dermatologisches Lokaltherapeutikum. Hautarzt 53:724–729

    Article  Google Scholar 

  24. Grabbe J, Welker P, Humke S et al. (1996) High-dose UVA1, but not UVA-UVB therapy decreases IgE binding cells in lesional skin of patients with atopic eczema. J Invest Dermatol 107:419–422

    CAS  PubMed  Google Scholar 

  25. Griffiths CE, van Leent EJ, Gilbert M, Traulsen J (2002) Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis. Br J Dermatol 147:299–307

    Article  CAS  PubMed  Google Scholar 

  26. Grundmann-Kollmann M, Podda M, Ochsendorf F et al. (2001) Mycophenolate mofetil is effective in the treatment of atopic dermatitis. Arch Dermatol 137:870–873

    CAS  PubMed  Google Scholar 

  27. Harper J, Green A, Scott G et al. (2001) First experience of topical SDZ ASM 981 in children with atopic dermatitis. Br J Dermatol 144:781–787

    Article  CAS  PubMed  Google Scholar 

  28. Harper JI, Berth-Jones J, Camp RDR et al. (2001) Cyclosporine for atopic dermatitis in children. Dermatology 203:3–6

    Article  CAS  PubMed  Google Scholar 

  29. Isolauri E, Arvola T, Sütas Y et al. (2000) Probiotics in the management of atopic eczema. Clin Exp Allergy 30:1604–1610

    Article  CAS  PubMed  Google Scholar 

  30. Jolles S (2002) A review of high-dose intravenous immunoglobulin treatment for atopic dermatitis. Clin Exp Dermatol 27:3–7

    Article  CAS  PubMed  Google Scholar 

  31. Kägi MK (1998) Aktuelle Empfehlungen für die Therapie des atopischen Ekzems. Allergologie 21:332–337

    Google Scholar 

  32. Krutman J (1999) Therapeutic photomedicine: phototherapy In: Freedberg IM, Eison AZ, Wolff K et al. (eds) Fitzpatrick's dermatology in general medicine, 5th edn. Mc Graw-Hill, New York, pp 2870–2879

  33. Krutmann J (2000) Phototherapy for atopic dermatitis. Clin Exp Dermatol 25:552–558

    Article  CAS  PubMed  Google Scholar 

  34. Krutmann J, Diepgen TL, Luger TA et al. (1998) High-dose UVA1 therapy für atopic dermatitis: results of a multicenter trial. J Am Acad Dermatol 38:589–593

    CAS  PubMed  Google Scholar 

  35. Leroy BP, Boden G, Lachapelle JM et al. (1997) A novel therapy for atopic dermatitis with allergen-antibody complexes: a double-blind, placebo-controlled study. J Am Acad Dermatol 28:232–239

    Google Scholar 

  36. Liu J (1993) FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. Immunol Today 14:290–295

    Google Scholar 

  37. Mastrandea F (2001) Immunotherapy in atopic dermatitis. Expert Opin Investig Drugs 10:49–63

    PubMed  Google Scholar 

  38. Meggitt SJ, Reynolds NJ (2001) Azathioprine for atopic dermatitis. Clin Exp Dermatol 26:369–375

    Article  CAS  PubMed  Google Scholar 

  39. Meurer M, Wozel G (2003) Behandlung des atopischen Ekzems bei Erwachsenen mit topischen Calcineurininhibtoren. Hautarzt 54:432–439

    PubMed  Google Scholar 

  40. Neuber K, Schwartz I, Itschert G, Dieck AT (2000) Treatment of atopic eczema with oral mycophenolate mofetil. Br J Dermatol 143:385–391

    Article  CAS  PubMed  Google Scholar 

  41. Niedner R (2003) Topische Kortikoide versus Calcineurinantagonisten. Hautarzt 54:338–341

    CAS  PubMed  Google Scholar 

  42. Nilsson EJ, Henning CG, Magnusson J (1992) Topical corticosteroids and staphylococcus aureus in atopic dermatitis. J Am Acad Dermatol 27:29–34

    CAS  PubMed  Google Scholar 

  43. Oishi Y, Fu ZW, Ohnuki Y et al. (2002) Molecular basis of the alteration in skin collagen metabolism in response to in vivo dexamethasone treatment: effects on the synthesis of collagen type I and III, collagenase, and tissue inhibitors of metalloproteinases. Br J Dermatol 147:859–868

    Article  CAS  PubMed  Google Scholar 

  44. Patel L, Clayton PE, Addison GM et al. (1995) Adrenal function following topical steroid treatment in children with atopic dermatitis. Br J Dermatol 132:950–955

    CAS  PubMed  Google Scholar 

  45. Peeters KA, Mascini EM, Blok HE, Sanders CJ (2002) Increase of resistance to fusidic acid among staphylococcus aureus isolates from patients admitted with atopic dermatitis. Ned Tijdschr Geneeskd 146:2100–2101

    CAS  PubMed  Google Scholar 

  46. Pei AYS, Chan HHL, Leung TF (2001) Montelukast in the treatment of children with moderate-to-severe atopic dermatitis: a pilot study. Pediatr Allergy Immunol 12:154–158

    Article  CAS  PubMed  Google Scholar 

  47. Pittler MH, Armstrong NC, Cox A et al. (2003) Randomized, double-blind, placebo-controlled trial of autologous blood therapy for atopic dermatitis. Br J Dermatol 148:307–313

    Article  CAS  PubMed  Google Scholar 

  48. Pournaras CC, Lübbe J, Saurat JH (2001) Staphylococcal colonization in atopic dermatitis treatment with topical tacrolimus (FK506). J Invest Dermatol 116:480–481

    Article  CAS  PubMed  Google Scholar 

  49. Queille-Roussel C, Paul C, Duteil L et al. (2001) The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. Br J Dermatol 144:507–513

    Article  CAS  PubMed  Google Scholar 

  50. Raap U, Jäger B, Werfel T, Schmid-Ott G (2003) Stress und Neurodermitis (dieses Themenheft)

  51. Reider N, Zloczower M, Fritsch P, Kofler H (1998) Antihistaminika Teil II. Hautarzt 49:734–742

    Article  CAS  PubMed  Google Scholar 

  52. Reitamo S, Wollenberg A, Schoepf E et al. (2000) Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. Arch Dermatol 136:999–1006

    CAS  PubMed  Google Scholar 

  53. Remitz A, Kyllönen H, Granlund H, Reitamo S (2001) Tacrolimus ointment reduces the staphylococcal colonization of atopic dermatitis lesions. J Allergy Clin Immunol 107:391–392

    Article  PubMed  Google Scholar 

  54. Richter H, Billmann-Eberwein C, Grewe M et al. (1998) Successfull monotherapy of severe and intractable atopic dermatitis by photopheresis. J Am Acad Dermatol 38:585–588

    CAS  PubMed  Google Scholar 

  55. Rosenfeldt V, Benfeldt E, Dam Nielsen S et al. (2003) Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol 111:389–395

    PubMed  Google Scholar 

  56. Schäfer T, Breuer K (2003) Epidemiologie von Nahrungsmittelallergien. Hautarzt 54:121–129

    PubMed  Google Scholar 

  57. Schempp CM, Effinger T, Czech W et al. (1997) Charakterisierung von Non-Respondern bei der hochdosierten UVA1-Therapie der akut exazerbierten atopischen Dermatitis. Hautarzt 48:94–99

    Article  CAS  PubMed  Google Scholar 

  58. Sheehan MP, Atherton DJ (1994) One-year follow up of children treated with chinese medicinal herbs for atopic aczema. Br J Dermatol 130:488–493

    CAS  PubMed  Google Scholar 

  59. Sporik R, Kemp AS (1997) Topical triclosan treatment of atopic dermatitis. J Allergy Clin Immunol 99:861

    CAS  Google Scholar 

  60. Stalder JF, Fleury M, Sourisse M et al. (1994) Local steroid therapy and bacterial skin flora in atopic dermatitis Br J Dermatol 131:536–540

    CAS  Google Scholar 

  61. Stockfleth E, Ulrich C, Meyer T, Christophers E (2002) Epithelial malignancies in organ transplant patients: clinical presentation and new methods of treatment. Recent Results Cancer Res 160:251–258

    CAS  PubMed  Google Scholar 

  62. Tan BB, Lear JT, Gwakrdger DJ, English JSC (1997) Azathioprine in dermatology: a survey of current practice in the U.K. Br J Dermatol 136:351–355

    CAS  PubMed  Google Scholar 

  63. von Kobyletzki G, Freitag M, Herde M et al. (1999) Phototherapie bei schwerer atopischer Dermatitis. Hautarzt 50:27–33

    Article  PubMed  Google Scholar 

  64. Warner JO (2001) A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18' posttreatment follow-up. J Allergy Clin Immunol 108:929–937

    CAS  PubMed  Google Scholar 

  65. Werfel T, Aberer W, Bieber T et al. (im Druck) Atopische Dermatitis. J Am Acad Dermatol

  66. Wilkinson JD (1998) Fusidic acid in dermatology. Br J Dermatol 139:37–40

    Article  CAS  PubMed  Google Scholar 

  67. Willeam REA, Gibson AG, Aitchison TC et al. (1990) Assessment of a contact-plate sampling technique and subsequent quantitative bacterial studies in atopic dermatitis. Br J Dermatol 123:493–501

    PubMed  Google Scholar 

  68. Wolthers OD, Heuck C, Ternowitz T et al. (1996) Insulin-like growth factor axis, bone and collagen turnover in children with atopic dermatitis treated with topical glucocorticosteroids. Dermatology 192:337–342

    CAS  PubMed  Google Scholar 

  69. Yanase MDJ, David-Bajaar K (2001) The leukotriene antagonist montelukast as a therapeutic agent for atopic dermatitis. J Am Acad Dermatol 44:89–93

    Article  CAS  PubMed  Google Scholar 

  70. Yoshimura M, Namura S, Akamatsu H, Horio T (1996) Antimicrobial effects of phototherapy and photochemotherapy in vivo and in vitro. Br J Dermatol 135:528–532

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Heratizadeh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heratizadeh, A., Breuer, K., Kapp, A. et al. Symptomatische Therapie der atopischen Dermatitis. Hautarzt 54, 937–945 (2003). https://doi.org/10.1007/s00105-003-0605-3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-003-0605-3

Schlüsselwörter

Keywords

Navigation