Zusammenfassung
Die Kenntnis darüber, dass Adenome über die Adenom-Karzinom-Sequenz früher oder später in einem bösartigen Tumor enden, erfordert die vollständige Entfernung kolorektaler Polypen. Deren Abtragung erfolgt in den meisten Fällen endoskopisch. Die Indikation zum operativen Vorgehen ergibt sich nur bei unvollständiger Abtragung, ungünstiger anatomischer Lage oder schon makroskopischem Malignomverdacht, wenn sich der Befund beim Unterspritzen nicht ausreichend abheben lässt. Sollte ein chirurgisches Vorgehen erforderlich sein, können bei ausreichend vorhandener Expertise auch minimal-invasive Verfahren zur Anwendung kommen.
Malignitätsverdächtige Adenome im mittleren und unteren Rektumdrittel sollten nicht zeitaufwendig und umständlich durch endoskopische Submukosadissektion abgetragen werden. Diese lassen sich transanal (konventionell oder durch transanale endoskopische Mikrochirurgie) chirurgisch schnell und sicher en bloc im Sinne einer Vollwandresektion resezieren, ermöglichen damit eine genaue pathologische Beurteilung hinsichtlich der Invasionstiefe und des zirkumferenziellen Resektionsrands und nur in High-risk-Konstellationen ist eine zusätzlich radikal-chirurgische Maßnahme erforderlich.
Abstract
The knowledge that due to the adenoma-cancer sequence polyps will develop sooner or later into invasive cancer demands the complete removal of colorectal polyps. The majority of polyps can be endoscopically removed. The indications for surgical removal of polyps are a previous incomplete endoscopic resection, location not amenable to endoscopic removal and lesions which are macroscopically highly suspicious for malignancy and cannot be detached by submucosal saline injection. If a surgical approach is indicated minimally invasive surgery in the hands of an experienced laparoscopic surgeon is a suitable option. Adenomas suspicious for malignancy in the lower two thirds of the rectum should not be treated by time-consuming endoscopic submucosal dissection (ESD) and can be quickly and safely removed transanally, conventionally or by transanal endoscopic microsurgery (TEM) by a full thickness én bloc resection. This allows the pathologist to determine the depth of invasion and the completeness of resection in terms of the circumferential margin and a definitive radical surgical approach is only necessary in high risk situations.
Literatur
Risio M (2010) The natural history of adenomas. Best Pract Res Clin Gastroenterol 24(4):397–406. Erratum in: Best Pract Res Clin Gastroentero (2010) 24(4):359
Snover D (2011) Update on the serrated pathway to colorectal carcinoma. Hum Pathol 42(1):1–10
Winawer SJ, Zauber AG, Ho MN et al (1993) Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 329(27):1977–1981
Hochdörffer R, Eickhoff A, Apel D et al (2010) Endoscopic resection of „giant“ colorectal lesions: long-term outcome and safety. Z Gastroenterol 48:741–747
AH Soune P, Ménard C, Salah E et al (2010) Large endoscopic mucosal resection for colorectal tumors exceeding 4 cm. World J Gastroenterol 16(5):588–595
Seitz U, Bohnacker S, Seewald S et al (2003) Long-term results of endoscopic removal of large colorectal adenomas. Endoscopy 35(8):41–44
Doniec JM, Löhnert MS, Schniewind B et al (2003) Endoscopic removal of large colorectal polyps: prevention of unnecessary surgery? Dis Colon Rectum 46(3):340–348
Puli SR, Kakugawa Y, Gotoda T et al (2009) Meta-analysis and review of colorectal endoscopic mucosal resection. World J Gastroenterol 15(34):4273–4237
Saito Y, Uraoka T, Yamaguchi Y et al (2010) A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video). Gastrointest Endosc 72(6):1217–1225
Saito Y, Sakamoto T, Fukunaga S et al (2009) Endoscopic submucosal dissection (ESD) for colorectal tumors. Dig Endosc. 21(Suppl 1):7–12
Niimi K, Fujishiro M, Kodashima S et al (2010) Long-term outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms. Endoscopy 42(9):723–729
Yoshida N, Naito Y, Sakai K et al (2010) Outcome of endoscopic submucosal dissection for colorectal tumors in elderly people. Int J Colorectal Dis 25(4):455–461
Benedix F, Köckerling F, Lippert H, Scheidbach H (2008) Laparoscopic resection for endoscopically unresectable colorectal polyps: analysis of 525 patients. Surg Endosc 22(12):2576–2582
Pokala N, Delaney CP, Kiran RP et al (2007) Outcome of laparoscopic colectomy for polyps not suitable for endoscopic resection. Surg Endosc 21(3):400–403
Lo SH, Law WL (2005) Laparoscopic colorectal resection for polyps not suitable for colonoscopic removal. Surg Endosc 19(9):1252–1255
Hauenschild L, Bader FG, Laubert T et al (2009) Laparoscopic colorectal resection for benign polyps not suitable for endoscopic polypectomy. Int J Colorectal Dis 24(7):755–759
Pokala N, Delaney CP, Kiran RP et al (2007) Outcome of laparoscopic colectomy for polyps not suitable for endoscopic resection. Surg Endosc 21(3):400–403
Schwenk W, Haase O, Neudecker J, Müller JM (2005) Short term benefits for laparoscopic colorectal resection. Cochrane Database Syst Rev 20(3):CD003145
Veldkamp R, Kuhry E, Hop WC et al (2005) Colon cancer laparoscopic or open resection study group (COLOR). Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6(7):477–484
Franklin ME Jr, Leyva-Alvizo A, Abrego-Medina D et al (2007) Laparoscopically monitored colonoscopic polypectomy: an established form of endoluminal therapy for colorectal polyps. Surg Endosc 21(9):1650–1653
Prohm P, Weber J, Bönner C (2001) Laparoscopic-assisted coloscopic polypectomy. Dis Colon Rectum 44(5):746–748
Smedh K, Skullman S, Kald A et al (1997) Laparoscopic bowel mobilization combined with intraoperative colonoscopic polypectomy in patients with an inaccessible polyp of the colon. Surg Endosc 11(6):643–644
Wilhelm D, Delius S von, Weber L et al (2009) Combined laparoscopic-endoscopic resections of colorectal polyps: 10-year experience and follow-up. Surg Endosc 23(4):688–693
Winter H, Lang RA, Spelsberg FW et al (2007) Laparoscopic colonoscopic rendezvous procedures for the treatment of polyps and early stage carcinomas of the colon. Int J Colorectal Dis 22(11):1377–1381
Schmiegel W, Reinacher-Schick A, Arnold D et al (2008) Update S3-guideline „colorectal cancer“ 2008. Z Gastroenterol 46:799–840
Kneist W, Terzic A, Burghardt J et al (2004) Selection of patients with rectal tumors for local excision based on preoperative diagnosis. Results of a consecutive evaluation study of 552 patients. Chirurg 75(2):168–175
Choi PW, Yu CS, Jang SJ et al (2008) Risk factors for lymph node metastasis in submucosal invasive colorectal cancer. World J Surg 32(9):2089–2094
Park YJ, Kim WH, Paeng SS, Park JG (2000) Histoclinical analysis of early colorectal cancer. World J Surg 24(9):1029–1035
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Rüth, S., Spatz, J. & Anthuber, M. Kolorektale Adenome: Pro konventionelle/laparoskopische Resektion. Chirurg 82, 520–525 (2011). https://doi.org/10.1007/s00104-010-2062-8
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DOI: https://doi.org/10.1007/s00104-010-2062-8
Schlüsselwörter
- Kolorektale Adenome
- Konventionelle Resektion
- Laparoskopische Resektion
- Malignomverdacht
- Risikokonstellationen