Zusammenfassung
Der Einsatz des Pulmonalarterienkatheters (PAK) zur erweiterten hämodynamischen Überwachung wird in der konservativen und operativen Medizin in den letzten Jahren zunehmend kritisch hinterfragt. Seit Mitte der 90er-Jahre zeigte sich, dass der Einsatz des Pulmonalarterienkatheters die Letalität und Morbidität schwerstkranker Patienten nicht positiv beeinflusst. In einigen Untersuchungen fand sich sogar eine höhere Letalität bei Patienten, die mit dem PAK überwacht wurden. Daher wurden in den letzten Jahren randomisierte Untersuchungen mit adäquater Fallzahl bei Patienten mit ARDS, Herzinsuffizienz, Multiorganversagen und Hochrisikochirurgie durchgeführt. In der Mehrzahl der aktuellen Untersuchungen zeigte sich kein positiver Einfluss des Monitorings mit dem PAK auf das Überleben und die Komplikationsrate. Der vorliegende Beitrag gibt eine Übersicht über Messparameter der aktuellen PAK-Generation, mögliche Alternativen und die aktuelle Studienlage zum Einsatz des PAK in der Anästhesie und Intensivmedizin
Abstract
The indication for the use of the pulmonary artery catheter (PAC) in high-risk patients is still a matter of discussion. Observational studies suggested that the use of the PAC did not result in decreased mortality but may even lead to increased mortality and morbidity. Therefore, a number of randomized controlled trials have been performed throughout recent years in patients suffering from sepsis/ARDS, congestive heart failure, multi-organ failure and those undergoing high-risk non-cardiac surgery. The majority of recent randomized studies failed to demonstrate any benefit of the PAC with respect to mortality and morbidity. However, the use of the PAC was also regularly not associated with an increase in morbidity and/or mortality. This review gives an overview of measurement parameters obtained by the current generation of PACs, alternatives to the PAC and recent studies on the use of the PAC in clinical practice.
Literatur
American Society of Anesthesiologists Task Force on Pulmonary Artery Catheterization (2003) Practice guidelines for pulmonary artery catheterization: an updated report by the American Society of Anesthesiologists Task Force on Pulmonary Artery Catheterization. Anesthesiology 99: 988–1014
Bein B, Worthmann F, Tonner PH et al. (2004) Comparison of esophageal Doppler, pulse contour analysis, and real-time pulmonary artery thermodilution for the continuous measurement of cardiac output. J Cardiothorac Vasc Anesth 18: 185–189
Binanay C, Califf RM, Hasselblad V et al. (2005) Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial. JAMA 294: 1625–1633
Bishop MH, Shoemaker WC, Appel PL et al. (1995) Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma 38: 780–787
Bottiger BW, Rauch H, Bohrer H et al. (1995) Continuous versus intermittent cardiac output measurement in cardiac surgical patients undergoing hypothermic cardiopulmonary bypass. J Cardiothorac Vasc Anesth 9: 405–411
Boyd O, Grounds RM, Bennett ED (1993) A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 270: 2699–2707
Buhre W, Buhre K, Kazmaier S et al. (2001) Assessment of cardiac preload by indicator dilution and transoesophageal echocardiography. Eur J Anaesthesiol 18: 662–667
Buhre W, Kazmaier S, Sonntag H, Weyland A (2001) Changes in cardiac output and intrathoracic blood volume: a mathematical coupling of data? Acta Anaesthesiol Scand 45: 863–867
Buhre W, Weyland A, Kazmaier S et al. (1999) Comparison of cardiac output assessed by pulse-contour analysis and thermodilution in patients undergoing minimally invasive direct coronary artery bypass grafting. J Cardiothorac Vasc Anesth 13: 437–440
Buhre W, Weyland A, Schorn B et al. (1999) Changes in central venous pressure and pulmonary capillary wedge pressure do not indicate changes in right and left heart volume in patients undergoing coronary artery bypass surgery. Eur J Anaesthesiol 16: 11–17
Cohen MG, Kelly RV, Kong DF et al. (2005) Pulmonary artery catheterization in acute coronary syndromes: insights from the GUSTO IIb and GUSTO III trials. Am J Med 118: 482–488
Connors AF Jr, Speroff T, Dawson NV et al. (1996) The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators. JAMA 276: 889–897
Dark PM, Singer M (2004) The validity of trans-esophageal Doppler ultrasonography as a measure of cardiac output in critically ill adults. Intensive Care Med 30: 2060–2066
De Simone R, Wolf I, Mottl-Link S et al. (2005) Intraoperative assessment of right ventricular volume and function. Eur J Cardiothorac Surg 27: 988–993
Dellinger RP, Carlet JM, Masur H et al. (2004) Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32: 858–873
Domino KB, Bowdle TA, Posner KL et al. (2004) Injuries and liability related to central vascular catheters: a closed claims analysis. Anesthesiology 100: 1411–1418
Dueck MH, Klimek M, Appenrodt S et al. (2005) Trends but not individual values of central venous oxygen saturation agree with mixed venous oxygen saturation during varying hemodynamic conditions. Anesthesiology 103: 249–257
Gan TJ, Soppitt A, Maroof M et al. (2002) Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology 97: 820–826
Gattinoni L, Brazzi L, Pelosi P et al. (1995) A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 333: 1025–1032
Hall JB (2005) Searching for evidence to support pulmonary artery catheter use in critically ill patients. JAMA 294: 1693–1694
Harvey S, Harrison DA, Singer M et al. (2005) Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet 366: 472–477
Hayes MA, Timmins AC, Yau EH et al. (1994) Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330: 1717–1722
Hofer CK, Furrer L, Matter-Ensner S et al. (2005) Volumetric preload measurement by thermodilution: a comparison with transoesophageal echocardiography. Br J Anaesth 94: 748–755
Kumar A, Anel R, Bunnell E et al. (2004) Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study. Crit Care 8: R128–136
Linton RA, Band DM, Haire KM (1993) A new method of measuring cardiac output in man using lithium dilution. Br J Anaesth 71: 262–266
McKendry M, McGloin H, Saberi D et al. (2004) Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery. Bmj 329: 258
Mielck F, Buhre W, Hanekop G et al. (2003) Comparison of continuous cardiac output measurements in patients after cardiac surgery. J Cardiothorac Vasc Anesth 17: 211–216
Neuhauser C, Muller M, Brau M et al. (2002) Partial CO(2) rebreathing technique versus thermodilution: measurement of cardiac output before and after operations with extracorporeal circulation. Anaesthesist 51: 25–633
Pearse R, Dawson D, Fawcett J et al. (2005) Changes in central venous saturation after major surgery, and association with outcome. Crit Care 9: R694–699
Pearse R, Dawson D, Fawcett J et al. (2005) Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]. Crit Care 9: R687–693
Pinsky MR, Vincent JL (2005) Let us use the pulmonary artery catheter correctly and only when we need it. Crit Care Med 33: 1119–1122
Poelaert J, Schmidt C, Van Aken H et al. (1999) A comparison of transoesophageal echocardiographic Doppler across the aortic valve and the thermodilution technique for estimating cardiac output. Anaesthesia 54: 128–136
Polonen P, Ruokonen E, Hippelainen M et al. (2000) A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients. Anesth Analg 90: 1052–1059
Procaccini B, Clementi G (2004) Pulmonary artery catheterization in 9071 cardiac surgery patients: a review of complications. Ital Heart J Suppl 5: 891–899
Reinhart K, Kuhn HJ, Hartog C, Bredle DL (2004) Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill. Intensive Care Med 30: 1572–1578
Reuter DA, Goetz AE (2005) Measurement of cardiac output. Anaesthesist 54: 1135–1151; quiz 1152–1133
Rhodes A, Bennett ED (2004) Early goal-directed therapy: an evidence-based review. Crit Care Med 32: S448–450
Rhodes A, Cusack RJ, Newman PJ et al. (2002) A randomised, controlled trial of the pulmonary artery catheter in critically ill patients. Intensive Care Med 28: 256–264
Richard C, Warszawski J, Anguel N et al. (2003) Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: a randomized controlled trial. JAMA 290: 2713–2720
Rivers E, Nguyen B, Havstad S et al. (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345: 1368–1377
Sakr Y, Vincent JL, Reinhart K et al. (2005) Use of the pulmonary artery catheter is not associated with worse outcome in the ICU. Chest 128: 2722–2731
Sandham JD, Hull RD, Brant RF et al. (2003) A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med 348: 5–14
Shah MR, Hasselblad V, Stevenson LW et al. (2005) Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials. JAMA 294: 1664–1670
Shoemaker WC, Appel PL, Kram HB et al. (1988) Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 94: 1176–1186
Shoemaker WC, Appel PL, Waxman K et al. (1982) Clinical trial of survivors‘ cardiorespiratory patterns as therapeutic goals in critically ill postoperative patients. Crit Care Med 10: 398–403
Sinclair S, James S, Singer M (1997) Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial. Bmj 315: 909–912
Swan HJ, Ganz W, Forrester J et al. (1970) Catheterization of the heart in man with use of a flow-directed balloon-tipped catheter. N Engl J Med 283: 447–451
Versprille A (1984) Pulmonary vascular resistance. A meaningless variable. Intensive Care Med 10: 51–53
Wakeling HG, McFall MR, Jenkins CS et al. (2005) Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery. Br J Anaesth 95: 634–642
Yu M, Levy MM, Smith P et al. (1993) Effect of maximizing oxygen delivery on morbidity and mortality rates in critically ill patients: a prospective, randomized, controlled study. Crit Care Med 21: 830–838
Interessenkonflikt
Der korrespondierende Autor weist auf eine Verbindung mit folgender Firma/Firmen hin: Der korrespondierende Autor ist Mitglied des Medical Advisory Board der Pulsion Medical Systems AG und hat von der Fa. Pulsion Honorare für Vorträge erhalten.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
de Waal, E.E.C., de Rossi, L. & Buhre, W. Pulmonalarterienkatheter. Anaesthesist 55, 713–730 (2006). https://doi.org/10.1007/s00101-006-1037-0
Issue Date:
DOI: https://doi.org/10.1007/s00101-006-1037-0
Schlüsselwörter
- Pulmonalarterienkatheter
- Thermodilutionstechnik
- Herzzeitvolumen
- Pulmonale Drücke
- Hämodynamische Überwachung